Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate.
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Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. / Kiefer, F; Witt, S H; Frank, J; Richter, A; Treutlein, J; Lemenager, T; Nöthen, M M; Cichon, S; Batra, A; Berner, M; Wodarz, N; Zimmermann, U S; Spanagel, R; Wiedemann, Klaus; Smolka, M N; Heinz, A; Rietschel, M; Mann, K.
In: PHARMACOGENOMICS J, Vol. 11, No. 5, 5, 2011, p. 368-374.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate.
AU - Kiefer, F
AU - Witt, S H
AU - Frank, J
AU - Richter, A
AU - Treutlein, J
AU - Lemenager, T
AU - Nöthen, M M
AU - Cichon, S
AU - Batra, A
AU - Berner, M
AU - Wodarz, N
AU - Zimmermann, U S
AU - Spanagel, R
AU - Wiedemann, Klaus
AU - Smolka, M N
AU - Heinz, A
AU - Rietschel, M
AU - Mann, K
PY - 2011
Y1 - 2011
N2 - In alcoholism, both relapse to alcohol drinking and treatment response are suggested to be genetically modulated. This study set out to determine whether the top 15 single nucleotide polymorphisms (SNPs) of a recent genome-wide association (GWA) and follow-up study of alcohol dependence are associated with relapse behavior and pharmacological treatment response in 374 alcohol-dependent subjects who underwent a randomized, double-blind, placebo-controlled trial with acamprosate, naltrexone or placebo. The single nucleotide polymorphism, rs13273672, an intronic SNP in the gene for GATA-binding protein 4 (GATA4), was associated with relapse within the 90-day medical treatment period (P
AB - In alcoholism, both relapse to alcohol drinking and treatment response are suggested to be genetically modulated. This study set out to determine whether the top 15 single nucleotide polymorphisms (SNPs) of a recent genome-wide association (GWA) and follow-up study of alcohol dependence are associated with relapse behavior and pharmacological treatment response in 374 alcohol-dependent subjects who underwent a randomized, double-blind, placebo-controlled trial with acamprosate, naltrexone or placebo. The single nucleotide polymorphism, rs13273672, an intronic SNP in the gene for GATA-binding protein 4 (GATA4), was associated with relapse within the 90-day medical treatment period (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 11
SP - 368
EP - 374
JO - PHARMACOGENOMICS J
JF - PHARMACOGENOMICS J
SN - 1470-269X
IS - 5
M1 - 5
ER -