Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence.
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Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence. / von der Goltz, Christoph; Koopmann, Anne; Dinter, Christina; Richter, Anne; Grosshans, Martin; Fink, Torsten; Wiedemann, Klaus; Kiefer, Falk.
In: HORM BEHAV, Vol. 60, No. 5, 5, 2011, p. 644-650.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Involvement of orexin in the regulation of stress, depression and reward in alcohol dependence.
AU - von der Goltz, Christoph
AU - Koopmann, Anne
AU - Dinter, Christina
AU - Richter, Anne
AU - Grosshans, Martin
AU - Fink, Torsten
AU - Wiedemann, Klaus
AU - Kiefer, Falk
PY - 2011
Y1 - 2011
N2 - There is growing evidence from preclinical studies for an involvement of orexins (ORX) in the regulation of stress, affectivity and addictive behavior. The aim of our study was to gather corresponding clinical data and to elucidate the relationships between alcohol withdrawal stress, ORX plasma concentration and psychopathology. A consecutive sample of thirty-four alcohol-dependent inpatients was included in the study. Blood was drawn at onset of withdrawal and following 2 weeks of controlled abstinence in order to assess ORX, ACTH and cortisol plasma concentrations. In parallel, we assessed clinically relevant psychological distress symptoms applying the Brief Symptom Inventory (BSI). We found a significant positive correlation between ORX and global distress indices of the BSI (p ? 0.05). In a regression model, ORX concentration during acute withdrawal explained 24% of the variance of symptom severity (p<0.01). No association with craving, ACTH or cortisol plasma concentration was detected. Our results suggest an involvement of ORX in the affective dysregulation seen commonly in alcohol dependent patients during alcohol withdrawal. Moreover, the effects on global distress indices as well as the earlier studied effects on reinstatement of drug seeking behaviors may point on an involvement of ORX in impaired brain stress systems.
AB - There is growing evidence from preclinical studies for an involvement of orexins (ORX) in the regulation of stress, affectivity and addictive behavior. The aim of our study was to gather corresponding clinical data and to elucidate the relationships between alcohol withdrawal stress, ORX plasma concentration and psychopathology. A consecutive sample of thirty-four alcohol-dependent inpatients was included in the study. Blood was drawn at onset of withdrawal and following 2 weeks of controlled abstinence in order to assess ORX, ACTH and cortisol plasma concentrations. In parallel, we assessed clinically relevant psychological distress symptoms applying the Brief Symptom Inventory (BSI). We found a significant positive correlation between ORX and global distress indices of the BSI (p ? 0.05). In a regression model, ORX concentration during acute withdrawal explained 24% of the variance of symptom severity (p<0.01). No association with craving, ACTH or cortisol plasma concentration was detected. Our results suggest an involvement of ORX in the affective dysregulation seen commonly in alcohol dependent patients during alcohol withdrawal. Moreover, the effects on global distress indices as well as the earlier studied effects on reinstatement of drug seeking behaviors may point on an involvement of ORX in impaired brain stress systems.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Severity of Illness Index
KW - Adrenocorticotropic Hormone/blood
KW - Reward
KW - Hydrocortisone/blood
KW - Alcoholism/blood/psychology
KW - Depression/blood/psychology
KW - Intracellular Signaling Peptides and Proteins/blood
KW - Neuropeptides/blood
KW - Stress, Psychological/blood
KW - Substance Withdrawal Syndrome/blood/psychology
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Severity of Illness Index
KW - Adrenocorticotropic Hormone/blood
KW - Reward
KW - Hydrocortisone/blood
KW - Alcoholism/blood/psychology
KW - Depression/blood/psychology
KW - Intracellular Signaling Peptides and Proteins/blood
KW - Neuropeptides/blood
KW - Stress, Psychological/blood
KW - Substance Withdrawal Syndrome/blood/psychology
M3 - SCORING: Journal article
VL - 60
SP - 644
EP - 650
JO - HORM BEHAV
JF - HORM BEHAV
SN - 0018-506X
IS - 5
M1 - 5
ER -
