Investigation of sex differences in delusion-associated cognitive biases

  • Chloé de Vos
  • Letizia Leanza
  • Amatya Mackintosh
  • Thies Lüdtke
  • Ryan Balzan
  • Steffen Moritz
  • Christina Andreou

Abstract

In the past few decades, sex differences have been identified in a number of clinical, cognitive and functional outcomes in patients with schizophrenia spectrum disorders. However, to date, sex differences in higher-order cognitive biases have not been systematically studied. The present study aimed to examine sex differences in jumping-to-conclusions and evidence integration impairment based on data collected in two previous studies in patients with schizophrenia spectrum disorders and healthy controls. For this purpose, data from n = 58 patients and n = 60 healthy controls on the Fish Task (as a measure of jumping to conclusions) and bias against disconfirmatory evidence (BADE; as a measure of evidence integration) task were analyzed. Results indicated a lack of sex differences in jumping-to-conclusions and evidence integration impairment both in patients with schizophrenia spectrum disorders and healthy controls. Although the present study was adequately powered to detect sex differences of a low medium effect size, larger studies are warranted to exclude differences of a smaller magnitude between men and women regarding delusion-associated cognitive biases.

Bibliographical data

Original languageEnglish
ISSN0165-1781
DOIs
Publication statusPublished - 02.2019
PubMed 30616118