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Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation

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Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation. / Schneider, Tanja; Kemmling, André; Schroeder, Julian; Pantel, Klaus; Glatzel, Markus; Schoen, Gerhard; Mohme, Malte; Fiehler, Jens; Gellißen, Susanne.

In: FRONT NEUROL, Vol. 9, 2018, p. 391.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Schneider, T, Kemmling, A, Schroeder, J, Pantel, K, Glatzel, M, Schoen, G, Mohme, M, Fiehler, J & Gellißen, S 2018, 'Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation', FRONT NEUROL, vol. 9, pp. 391. https://doi.org/10.3389/fneur.2018.00391

APA

Schneider, T., Kemmling, A., Schroeder, J., Pantel, K., Glatzel, M., Schoen, G., Mohme, M., Fiehler, J., & Gellißen, S. (2018). Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation. FRONT NEUROL, 9, 391. https://doi.org/10.3389/fneur.2018.00391

Vancouver

Schneider T, Kemmling A, Schroeder J, Pantel K, Glatzel M, Schoen G et al. Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation. FRONT NEUROL. 2018;9:391. https://doi.org/10.3389/fneur.2018.00391

Bibtex

@article{b00a6f1883034612873b06439b245589,
title = "Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation",
abstract = "Background and Aims: Vascular border zones and the gray-white matter junction are preferred sites for the development of brain metastases (BM), whereas microvascular lesions are known to be a protective factor. In this proof of concept study, we aim to study the relationship of blood perfusion and the spatial distribution of BM. Materials and Methods: An average CT perfusion atlas of 107 healthy patients was created. Voxel-wise reference perfusion values were extracted from BM-negative and BM-positive regions in a second cohort of 100 untreated patients harboring 809 BM confirmed by MRI. A comparison of regional perfusion values was performed using the independent t-test. Results: In contrast to supratentorial BM that develop preferably in areas with lower CBV/CBF and longer MTT/TTP compared to the average regional perfusion (p < 0.001), infratentorial BM showed a higher CBV/CBF and shorter MTT/TTP (p < 0.001). Conclusion: Our results imply differing pathophysiological mechanisms underlying supra- and infratentorial BM spreading. The inverse perfusion patterns may result from differences in vascular supply, hemodynamic requirements, and/or production of pro-angiogenic factors.",
author = "Tanja Schneider and Andr{\'e} Kemmling and Julian Schroeder and Klaus Pantel and Markus Glatzel and Gerhard Schoen and Malte Mohme and Jens Fiehler and Susanne Gelli{\ss}en",
year = "2018",
doi = "10.3389/fneur.2018.00391",
language = "English",
volume = "9",
pages = "391",
journal = "FRONT NEUROL",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Inverse Perfusion Requirements of Supra- and Infratentorial Brain Metastases Formation

AU - Schneider, Tanja

AU - Kemmling, André

AU - Schroeder, Julian

AU - Pantel, Klaus

AU - Glatzel, Markus

AU - Schoen, Gerhard

AU - Mohme, Malte

AU - Fiehler, Jens

AU - Gellißen, Susanne

PY - 2018

Y1 - 2018

N2 - Background and Aims: Vascular border zones and the gray-white matter junction are preferred sites for the development of brain metastases (BM), whereas microvascular lesions are known to be a protective factor. In this proof of concept study, we aim to study the relationship of blood perfusion and the spatial distribution of BM. Materials and Methods: An average CT perfusion atlas of 107 healthy patients was created. Voxel-wise reference perfusion values were extracted from BM-negative and BM-positive regions in a second cohort of 100 untreated patients harboring 809 BM confirmed by MRI. A comparison of regional perfusion values was performed using the independent t-test. Results: In contrast to supratentorial BM that develop preferably in areas with lower CBV/CBF and longer MTT/TTP compared to the average regional perfusion (p < 0.001), infratentorial BM showed a higher CBV/CBF and shorter MTT/TTP (p < 0.001). Conclusion: Our results imply differing pathophysiological mechanisms underlying supra- and infratentorial BM spreading. The inverse perfusion patterns may result from differences in vascular supply, hemodynamic requirements, and/or production of pro-angiogenic factors.

AB - Background and Aims: Vascular border zones and the gray-white matter junction are preferred sites for the development of brain metastases (BM), whereas microvascular lesions are known to be a protective factor. In this proof of concept study, we aim to study the relationship of blood perfusion and the spatial distribution of BM. Materials and Methods: An average CT perfusion atlas of 107 healthy patients was created. Voxel-wise reference perfusion values were extracted from BM-negative and BM-positive regions in a second cohort of 100 untreated patients harboring 809 BM confirmed by MRI. A comparison of regional perfusion values was performed using the independent t-test. Results: In contrast to supratentorial BM that develop preferably in areas with lower CBV/CBF and longer MTT/TTP compared to the average regional perfusion (p < 0.001), infratentorial BM showed a higher CBV/CBF and shorter MTT/TTP (p < 0.001). Conclusion: Our results imply differing pathophysiological mechanisms underlying supra- and infratentorial BM spreading. The inverse perfusion patterns may result from differences in vascular supply, hemodynamic requirements, and/or production of pro-angiogenic factors.

U2 - 10.3389/fneur.2018.00391

DO - 10.3389/fneur.2018.00391

M3 - SCORING: Journal article

C2 - 29899729

VL - 9

SP - 391

JO - FRONT NEUROL

JF - FRONT NEUROL

SN - 1664-2295

ER -