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Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature

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Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature. / Pauly, Mira J; Rohde, Julia K; John, Clara; Evangelakos, Ioannis; Koop, Anja Christina; Pertzborn, Paul; Tödter, Klaus; Scheja, Ludger; Heeren, Joerg; Worthmann, Anna.

In: NUTRIENTS, Vol. 12, No. 10, 20.10.2020.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Pauly, MJ, Rohde, JK, John, C, Evangelakos, I, Koop, AC, Pertzborn, P, Tödter, K, Scheja, L, Heeren, J & Worthmann, A 2020, 'Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature', NUTRIENTS, vol. 12, no. 10. https://doi.org/10.3390/nu12103200

APA

Pauly, M. J., Rohde, J. K., John, C., Evangelakos, I., Koop, A. C., Pertzborn, P., Tödter, K., Scheja, L., Heeren, J., & Worthmann, A. (2020). Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature. NUTRIENTS, 12(10). https://doi.org/10.3390/nu12103200

Vancouver

Pauly MJ, Rohde JK, John C, Evangelakos I, Koop AC, Pertzborn P et al. Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature. NUTRIENTS. 2020 Oct 20;12(10). https://doi.org/10.3390/nu12103200

Bibtex

@article{a6ad659882c7413991af95345d3564db,
title = "Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature",
abstract = "Dietary fibers are fermented by gut bacteria into the major short chain fatty acids (SCFAs) acetate, propionate, and butyrate. Generally, fiber-rich diets are believed to improve metabolic health. However, recent studies suggest that long-term supplementation with fibers causes changes in hepatic bile acid metabolism, hepatocyte damage, and hepatocellular cancer in dysbiotic mice. Alterations in hepatic bile acid metabolism have also been reported after cold-induced activation of brown adipose tissue. Here, we aim to investigate the effects of short-term dietary inulin supplementation on liver cholesterol and bile acid metabolism in control and cold housed specific pathogen free wild type (WT) mice. We found that short-term inulin feeding lowered plasma cholesterol levels and provoked cholestasis and mild liver damage in WT mice. Of note, inulin feeding caused marked perturbations in bile acid metabolism, which were aggravated by cold treatment. Our studies indicate that even relatively short periods of inulin consumption in mice with an intact gut microbiome have detrimental effects on liver metabolism and function.",
author = "Pauly, {Mira J} and Rohde, {Julia K} and Clara John and Ioannis Evangelakos and Koop, {Anja Christina} and Paul Pertzborn and Klaus T{\"o}dter and Ludger Scheja and Joerg Heeren and Anna Worthmann",
year = "2020",
month = oct,
day = "20",
doi = "10.3390/nu12103200",
language = "English",
volume = "12",
journal = "NUTRIENTS",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "10",

}

RIS

TY - JOUR

T1 - Inulin Supplementation Disturbs Hepatic Cholesterol and Bile Acid Metabolism Independent from Housing Temperature

AU - Pauly, Mira J

AU - Rohde, Julia K

AU - John, Clara

AU - Evangelakos, Ioannis

AU - Koop, Anja Christina

AU - Pertzborn, Paul

AU - Tödter, Klaus

AU - Scheja, Ludger

AU - Heeren, Joerg

AU - Worthmann, Anna

PY - 2020/10/20

Y1 - 2020/10/20

N2 - Dietary fibers are fermented by gut bacteria into the major short chain fatty acids (SCFAs) acetate, propionate, and butyrate. Generally, fiber-rich diets are believed to improve metabolic health. However, recent studies suggest that long-term supplementation with fibers causes changes in hepatic bile acid metabolism, hepatocyte damage, and hepatocellular cancer in dysbiotic mice. Alterations in hepatic bile acid metabolism have also been reported after cold-induced activation of brown adipose tissue. Here, we aim to investigate the effects of short-term dietary inulin supplementation on liver cholesterol and bile acid metabolism in control and cold housed specific pathogen free wild type (WT) mice. We found that short-term inulin feeding lowered plasma cholesterol levels and provoked cholestasis and mild liver damage in WT mice. Of note, inulin feeding caused marked perturbations in bile acid metabolism, which were aggravated by cold treatment. Our studies indicate that even relatively short periods of inulin consumption in mice with an intact gut microbiome have detrimental effects on liver metabolism and function.

AB - Dietary fibers are fermented by gut bacteria into the major short chain fatty acids (SCFAs) acetate, propionate, and butyrate. Generally, fiber-rich diets are believed to improve metabolic health. However, recent studies suggest that long-term supplementation with fibers causes changes in hepatic bile acid metabolism, hepatocyte damage, and hepatocellular cancer in dysbiotic mice. Alterations in hepatic bile acid metabolism have also been reported after cold-induced activation of brown adipose tissue. Here, we aim to investigate the effects of short-term dietary inulin supplementation on liver cholesterol and bile acid metabolism in control and cold housed specific pathogen free wild type (WT) mice. We found that short-term inulin feeding lowered plasma cholesterol levels and provoked cholestasis and mild liver damage in WT mice. Of note, inulin feeding caused marked perturbations in bile acid metabolism, which were aggravated by cold treatment. Our studies indicate that even relatively short periods of inulin consumption in mice with an intact gut microbiome have detrimental effects on liver metabolism and function.

U2 - 10.3390/nu12103200

DO - 10.3390/nu12103200

M3 - SCORING: Journal article

C2 - 33092056

VL - 12

JO - NUTRIENTS

JF - NUTRIENTS

SN - 2072-6643

IS - 10

ER -