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Intrinsically organized resting state networks in the human spinal cord

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Intrinsically organized resting state networks in the human spinal cord. / Kong, Yazhuo; Eippert, Falk; Beckmann, Christian F; Andersson, Jesper; Finsterbusch, Jürgen; Büchel, Christian; Tracey, Irene; Brooks, Jonathan C W.

In: P NATL ACAD SCI USA, Vol. 111, No. 50, 2014, p. 18067-72.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Kong, Y, Eippert, F, Beckmann, CF, Andersson, J, Finsterbusch, J, Büchel, C, Tracey, I & Brooks, JCW 2014, 'Intrinsically organized resting state networks in the human spinal cord', P NATL ACAD SCI USA, vol. 111, no. 50, pp. 18067-72. https://doi.org/10.1073/pnas.1414293111

APA

Kong, Y., Eippert, F., Beckmann, C. F., Andersson, J., Finsterbusch, J., Büchel, C., Tracey, I., & Brooks, J. C. W. (2014). Intrinsically organized resting state networks in the human spinal cord. P NATL ACAD SCI USA, 111(50), 18067-72. https://doi.org/10.1073/pnas.1414293111

Vancouver

Kong Y, Eippert F, Beckmann CF, Andersson J, Finsterbusch J, Büchel C et al. Intrinsically organized resting state networks in the human spinal cord. P NATL ACAD SCI USA. 2014;111(50):18067-72. https://doi.org/10.1073/pnas.1414293111

Bibtex

@article{7adc7f60582847a5ba0f957ab53cf508,
title = "Intrinsically organized resting state networks in the human spinal cord",
abstract = "Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain have repeatedly been observed when no task or external stimulation is present. These fluctuations likely reflect baseline neuronal activity of the brain and correspond to functionally relevant resting-state networks (RSN). It is not known however, whether intrinsically organized and spatially circumscribed RSNs also exist in the spinal cord, the brain's principal sensorimotor interface with the body. Here, we use recent advances in spinal fMRI methodology and independent component analysis to answer this question in healthy human volunteers. We identified spatially distinct RSNs in the human spinal cord that were clearly separated into dorsal and ventral components, mirroring the functional neuroanatomy of the spinal cord and likely reflecting sensory and motor processing. Interestingly, dorsal (sensory) RSNs were separated into right and left components, presumably related to ongoing hemibody processing of somatosensory information, whereas ventral (motor) RSNs were bilateral, possibly related to commissural interneuronal networks involved in central pattern generation. Importantly, all of these RSNs showed a restricted spatial extent along the spinal cord and likely conform to the spinal cord's functionally relevant segmental organization. Although the spatial and temporal properties of the dorsal and ventral RSNs were found to be significantly different, these networks showed significant interactions with each other at the segmental level. Together, our data demonstrate that intrinsically highly organized resting-state fluctuations exist in the human spinal cord and are thus a hallmark of the entire central nervous system.",
author = "Yazhuo Kong and Falk Eippert and Beckmann, {Christian F} and Jesper Andersson and J{\"u}rgen Finsterbusch and Christian B{\"u}chel and Irene Tracey and Brooks, {Jonathan C W}",
year = "2014",
doi = "10.1073/pnas.1414293111",
language = "English",
volume = "111",
pages = "18067--72",
journal = "P NATL ACAD SCI USA",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "50",

}

RIS

TY - JOUR

T1 - Intrinsically organized resting state networks in the human spinal cord

AU - Kong, Yazhuo

AU - Eippert, Falk

AU - Beckmann, Christian F

AU - Andersson, Jesper

AU - Finsterbusch, Jürgen

AU - Büchel, Christian

AU - Tracey, Irene

AU - Brooks, Jonathan C W

PY - 2014

Y1 - 2014

N2 - Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain have repeatedly been observed when no task or external stimulation is present. These fluctuations likely reflect baseline neuronal activity of the brain and correspond to functionally relevant resting-state networks (RSN). It is not known however, whether intrinsically organized and spatially circumscribed RSNs also exist in the spinal cord, the brain's principal sensorimotor interface with the body. Here, we use recent advances in spinal fMRI methodology and independent component analysis to answer this question in healthy human volunteers. We identified spatially distinct RSNs in the human spinal cord that were clearly separated into dorsal and ventral components, mirroring the functional neuroanatomy of the spinal cord and likely reflecting sensory and motor processing. Interestingly, dorsal (sensory) RSNs were separated into right and left components, presumably related to ongoing hemibody processing of somatosensory information, whereas ventral (motor) RSNs were bilateral, possibly related to commissural interneuronal networks involved in central pattern generation. Importantly, all of these RSNs showed a restricted spatial extent along the spinal cord and likely conform to the spinal cord's functionally relevant segmental organization. Although the spatial and temporal properties of the dorsal and ventral RSNs were found to be significantly different, these networks showed significant interactions with each other at the segmental level. Together, our data demonstrate that intrinsically highly organized resting-state fluctuations exist in the human spinal cord and are thus a hallmark of the entire central nervous system.

AB - Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain have repeatedly been observed when no task or external stimulation is present. These fluctuations likely reflect baseline neuronal activity of the brain and correspond to functionally relevant resting-state networks (RSN). It is not known however, whether intrinsically organized and spatially circumscribed RSNs also exist in the spinal cord, the brain's principal sensorimotor interface with the body. Here, we use recent advances in spinal fMRI methodology and independent component analysis to answer this question in healthy human volunteers. We identified spatially distinct RSNs in the human spinal cord that were clearly separated into dorsal and ventral components, mirroring the functional neuroanatomy of the spinal cord and likely reflecting sensory and motor processing. Interestingly, dorsal (sensory) RSNs were separated into right and left components, presumably related to ongoing hemibody processing of somatosensory information, whereas ventral (motor) RSNs were bilateral, possibly related to commissural interneuronal networks involved in central pattern generation. Importantly, all of these RSNs showed a restricted spatial extent along the spinal cord and likely conform to the spinal cord's functionally relevant segmental organization. Although the spatial and temporal properties of the dorsal and ventral RSNs were found to be significantly different, these networks showed significant interactions with each other at the segmental level. Together, our data demonstrate that intrinsically highly organized resting-state fluctuations exist in the human spinal cord and are thus a hallmark of the entire central nervous system.

U2 - 10.1073/pnas.1414293111

DO - 10.1073/pnas.1414293111

M3 - SCORING: Journal article

C2 - 25472845

VL - 111

SP - 18067

EP - 18072

JO - P NATL ACAD SCI USA

JF - P NATL ACAD SCI USA

SN - 0027-8424

IS - 50

ER -