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Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release

Standard

Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release. / Ruhe, Julia; Waldeyer, Christoph; Ojeda, Francisco; Altay, Alev; Schnabel, Renate B; Schäfer, Sarina; Lackner, Karl J; Blankenberg, Stefan; Zeller, Tanja; Karakas, Mahir.

In: BIOMOLECULES, Vol. 8, No. 3, 09.08.2018, p. E72.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Ruhe, J, Waldeyer, C, Ojeda, F, Altay, A, Schnabel, RB, Schäfer, S, Lackner, KJ, Blankenberg, S, Zeller, T & Karakas, M 2018, 'Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release', BIOMOLECULES, vol. 8, no. 3, pp. E72. https://doi.org/10.3390/biom8030072

APA

Ruhe, J., Waldeyer, C., Ojeda, F., Altay, A., Schnabel, R. B., Schäfer, S., Lackner, K. J., Blankenberg, S., Zeller, T., & Karakas, M. (2018). Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release. BIOMOLECULES, 8(3), E72. https://doi.org/10.3390/biom8030072

Vancouver

Ruhe J, Waldeyer C, Ojeda F, Altay A, Schnabel RB, Schäfer S et al. Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release. BIOMOLECULES. 2018 Aug 9;8(3):E72. https://doi.org/10.3390/biom8030072

Bibtex

@article{91b99bd962e74a98b2fb99c5525f8fa5,
title = "Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release",
abstract = "Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L). A commercially available ELISA (DRG) was used for measurements of serum hepcidin. Serum sTfR was determined by using an automated immunoassay (). Cardiovascular mortality was the main outcome measure. The criteria of intrinsic iron release were fulfilled in 32.6% of all patients. Significantly lower cardiovascular mortality rates were observed in CAD patients with systemic iron release. After adjustment for body mass index, smoking status, hypertension, diabetes, dyslipidemia, sex, and age, the hazard ratio for future cardiovascular death was 0.41. After an additional adjustment for surrogates of the size of myocardial necrosis (troponin I), anemia (hemoglobin), and cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide), this association did not change (Hazard ratio 0.37 (95% confidence interval 0.14⁻0.99), p = 0.047). In conclusion, significantly lower cardiovascular mortality rates were observed in CAD patients with intrinsic iron release shown during follow-up.",
keywords = "Aged, Coronary Artery Disease/diagnosis, Female, Hepcidins/metabolism, Humans, Iron/metabolism, Male, Middle Aged, Prognosis, Receptors, Transferrin/chemistry, Solubility",
author = "Julia Ruhe and Christoph Waldeyer and Francisco Ojeda and Alev Altay and Schnabel, {Renate B} and Sarina Sch{\"a}fer and Lackner, {Karl J} and Stefan Blankenberg and Tanja Zeller and Mahir Karakas",
year = "2018",
month = aug,
day = "9",
doi = "10.3390/biom8030072",
language = "English",
volume = "8",
pages = "E72",
journal = "BIOMOLECULES",
issn = "2218-273X",
publisher = "Multidisciplinary Digital Publishing Institute",
number = "3",

}

RIS

TY - JOUR

T1 - Intrinsic Iron Release Is Associated with Lower Mortality in Patients with Stable Coronary Artery Disease-First Report on the Prospective Relevance of Intrinsic Iron Release

AU - Ruhe, Julia

AU - Waldeyer, Christoph

AU - Ojeda, Francisco

AU - Altay, Alev

AU - Schnabel, Renate B

AU - Schäfer, Sarina

AU - Lackner, Karl J

AU - Blankenberg, Stefan

AU - Zeller, Tanja

AU - Karakas, Mahir

PY - 2018/8/9

Y1 - 2018/8/9

N2 - Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L). A commercially available ELISA (DRG) was used for measurements of serum hepcidin. Serum sTfR was determined by using an automated immunoassay (). Cardiovascular mortality was the main outcome measure. The criteria of intrinsic iron release were fulfilled in 32.6% of all patients. Significantly lower cardiovascular mortality rates were observed in CAD patients with systemic iron release. After adjustment for body mass index, smoking status, hypertension, diabetes, dyslipidemia, sex, and age, the hazard ratio for future cardiovascular death was 0.41. After an additional adjustment for surrogates of the size of myocardial necrosis (troponin I), anemia (hemoglobin), and cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide), this association did not change (Hazard ratio 0.37 (95% confidence interval 0.14⁻0.99), p = 0.047). In conclusion, significantly lower cardiovascular mortality rates were observed in CAD patients with intrinsic iron release shown during follow-up.

AB - Intrinsic iron release is discussed to have favorable effects in coronary artery disease (CAD). The aim of this study was to evaluate the prognostic relevance of intrinsic iron release in patients with CAD. Intrinsic iron release was based on a definition including hepcidin and soluble transferrin receptor (sTfR). In a cohort of 811 patients with angiographically documented CAD levels of hepcidin and sTfR were measured at baseline. Systemic body iron release was defined as low levels of hepcidin (<24 ng/mL) and high levels of sTfR (≥2 mg/L). A commercially available ELISA (DRG) was used for measurements of serum hepcidin. Serum sTfR was determined by using an automated immunoassay (). Cardiovascular mortality was the main outcome measure. The criteria of intrinsic iron release were fulfilled in 32.6% of all patients. Significantly lower cardiovascular mortality rates were observed in CAD patients with systemic iron release. After adjustment for body mass index, smoking status, hypertension, diabetes, dyslipidemia, sex, and age, the hazard ratio for future cardiovascular death was 0.41. After an additional adjustment for surrogates of the size of myocardial necrosis (troponin I), anemia (hemoglobin), and cardiac function and heart failure severity (N-terminal pro B-type natriuretic peptide), this association did not change (Hazard ratio 0.37 (95% confidence interval 0.14⁻0.99), p = 0.047). In conclusion, significantly lower cardiovascular mortality rates were observed in CAD patients with intrinsic iron release shown during follow-up.

KW - Aged

KW - Coronary Artery Disease/diagnosis

KW - Female

KW - Hepcidins/metabolism

KW - Humans

KW - Iron/metabolism

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Receptors, Transferrin/chemistry

KW - Solubility

U2 - 10.3390/biom8030072

DO - 10.3390/biom8030072

M3 - SCORING: Journal article

C2 - 30096922

VL - 8

SP - E72

JO - BIOMOLECULES

JF - BIOMOLECULES

SN - 2218-273X

IS - 3

ER -