Intravital Imaging Allows Organ-Specific Insights Into Immune Functions
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Intravital Imaging Allows Organ-Specific Insights Into Immune Functions. / Jorch, Selina K; Deppermann, Carsten.
In: FRONT CELL DEV BIOL, Vol. 9, 623906, 2021.Research output: SCORING: Contribution to journal › SCORING: Review article › Research
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TY - JOUR
T1 - Intravital Imaging Allows Organ-Specific Insights Into Immune Functions
AU - Jorch, Selina K
AU - Deppermann, Carsten
N1 - Copyright © 2021 Jorch and Deppermann.
PY - 2021
Y1 - 2021
N2 - Leukocytes are among the most mobile and versatile cells that have many essential functions in homeostasis and survival. Especially cells from the innate immune system, i.e., neutrophils and macrophages, play an important role as rapid first responders against invading microorganisms. With the advent of novel imaging techniques, new ways of visualizing innate immune cells have become available in recent years, thereby enabling more and more detailed discoveries about their nature, function and interaction partners. Besides intravital spinning-disc and 2-photon microscopy, clearing and 3D-imaging techniques provide new insights into the mechanism of innate immune cell behavior in their natural environment. This mini review focuses on the contributions of novel-imaging techniques to provide insight into the functions of neutrophils and macrophages under homeostasis and in infections. Imaging setups for different organs like the liver, kidney, heart, lung, and the peritoneal cavity are discussed as well as the current limitations of these imaging techniques.
AB - Leukocytes are among the most mobile and versatile cells that have many essential functions in homeostasis and survival. Especially cells from the innate immune system, i.e., neutrophils and macrophages, play an important role as rapid first responders against invading microorganisms. With the advent of novel imaging techniques, new ways of visualizing innate immune cells have become available in recent years, thereby enabling more and more detailed discoveries about their nature, function and interaction partners. Besides intravital spinning-disc and 2-photon microscopy, clearing and 3D-imaging techniques provide new insights into the mechanism of innate immune cell behavior in their natural environment. This mini review focuses on the contributions of novel-imaging techniques to provide insight into the functions of neutrophils and macrophages under homeostasis and in infections. Imaging setups for different organs like the liver, kidney, heart, lung, and the peritoneal cavity are discussed as well as the current limitations of these imaging techniques.
U2 - 10.3389/fcell.2021.623906
DO - 10.3389/fcell.2021.623906
M3 - SCORING: Review article
C2 - 33644061
VL - 9
JO - FRONT CELL DEV BIOL
JF - FRONT CELL DEV BIOL
SN - 2296-634X
M1 - 623906
ER -
