Intravenous and subcutaneous desferrioxamine therapy in children with severe iron overload.
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Intravenous and subcutaneous desferrioxamine therapy in children with severe iron overload. / Janka-Schaub, Gritta; Möhring, P; Helmig, M; Haas, R J; Betke, K.
In: EUR J PEDIATR, Vol. 137, No. 3, 3, 1981, p. 285-290.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Intravenous and subcutaneous desferrioxamine therapy in children with severe iron overload.
AU - Janka-Schaub, Gritta
AU - Möhring, P
AU - Helmig, M
AU - Haas, R J
AU - Betke, K
PY - 1981
Y1 - 1981
N2 - Ten children with transfusion dependent anemias (thalassemia, sideroblastic anemia, congenital pure red cell aplasia) received either intravenous desferrioxamine (DF) in increasing doses up to 450 mg/kg at the time of transfusion or daily subcutaneous DF up to 110 mg/kg on an outpatient basis. No patient on intravenous DF reached a negative iron balance. All children with a subcutaneous DF dose of more than 60 mg/kg obtained a negative iron balance with a net iron excretion (transfusion iron already substracted) between 206 to 810 mg (mean 496 mg) monthly. The effectiveness of regular subcutaneous DF on liver storage iron could be confirmed in 4 patients by liver biopsy, showing a decrease between 40-60% iron after 12-14 months of chelation therapy. So far the daily iron excretion has remained constant with a given dose of DF over a period up to 15 months. Even if poor compliance in some patients is taken into account, it is possible with this method of treatment to prevent further accumulation of iron in chronically transfused children.
AB - Ten children with transfusion dependent anemias (thalassemia, sideroblastic anemia, congenital pure red cell aplasia) received either intravenous desferrioxamine (DF) in increasing doses up to 450 mg/kg at the time of transfusion or daily subcutaneous DF up to 110 mg/kg on an outpatient basis. No patient on intravenous DF reached a negative iron balance. All children with a subcutaneous DF dose of more than 60 mg/kg obtained a negative iron balance with a net iron excretion (transfusion iron already substracted) between 206 to 810 mg (mean 496 mg) monthly. The effectiveness of regular subcutaneous DF on liver storage iron could be confirmed in 4 patients by liver biopsy, showing a decrease between 40-60% iron after 12-14 months of chelation therapy. So far the daily iron excretion has remained constant with a given dose of DF over a period up to 15 months. Even if poor compliance in some patients is taken into account, it is possible with this method of treatment to prevent further accumulation of iron in chronically transfused children.
M3 - SCORING: Zeitschriftenaufsatz
VL - 137
SP - 285
EP - 290
JO - EUR J PEDIATR
JF - EUR J PEDIATR
SN - 0340-6199
IS - 3
M1 - 3
ER -
