Intraoperative efficiency of fluorescence imaging by Visually Enhanced Lesion Scope (VELscope(®)) in patients with bisphosphonate related osteonecrosis of the jaw (BRONJ)
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Intraoperative efficiency of fluorescence imaging by Visually Enhanced Lesion Scope (VELscope(®)) in patients with bisphosphonate related osteonecrosis of the jaw (BRONJ). / Assaf, Alexandre T; Zrnc, Tomislav A; Riecke, Björn; Wikner, Johannes; Zustin, Josef; Friedrich, Reinhard E; Heiland, Max; Smeets, Ralf; Gröbe, Alexander.
In: J CRANIO MAXILL SURG, Vol. 42, No. 5, 2014, p. e157-e164.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Intraoperative efficiency of fluorescence imaging by Visually Enhanced Lesion Scope (VELscope(®)) in patients with bisphosphonate related osteonecrosis of the jaw (BRONJ)
AU - Assaf, Alexandre T
AU - Zrnc, Tomislav A
AU - Riecke, Björn
AU - Wikner, Johannes
AU - Zustin, Josef
AU - Friedrich, Reinhard E
AU - Heiland, Max
AU - Smeets, Ralf
AU - Gröbe, Alexander
N1 - Copyright © 2013 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
PY - 2014
Y1 - 2014
N2 - OBJECTIVES: The purpose of this study was to determine the potential of tissue fluorescence imaging by using Visually Enhanced Lesion Scope (VELscope(®)) for the detection of osteonecrosis of the jaw induced by bisphosphonates (BRONJ).METHODS: We investigated 20 patients (11 females and 9 males; mean age 74 years, standard deviation ± 6.4 years), over a period of 18 month with the diagnosis of BRONJ in this prospective cohort study. All patients received doxycycline as a fluorescending marker for osseous structures. VELscope(®) has been used intraoperatively using the loss of fluorescence to detect presence of osteonecrosis. Osseous biopsies were taken to confirm definite histopathological diagnosis of BRONJ in each case.RESULTS: Diagnosis of BRONJ was confirmed for every patient. In all patients except one, VELscope(®) was sufficient to differentiate between healthy and necrotic bone by visual fluorescence retention (VFR) and visual fluorescence loss (VFL). 19 cases out of a total of 20 showed no signs of recurrence of BRONJ during follow-up (mean 12 months, range 4-18 months).CONCLUSION: VELscope(®) examination is a suitable tool to visualize necrotic areas of the bone in patients with bisphosphonate related osteonecrosis of the jaw. Loss of fluorescence in necrotic bone areas is useful intraoperatively as a tool for fluorescence-guided bone resection with relevant clinical interpretation.
AB - OBJECTIVES: The purpose of this study was to determine the potential of tissue fluorescence imaging by using Visually Enhanced Lesion Scope (VELscope(®)) for the detection of osteonecrosis of the jaw induced by bisphosphonates (BRONJ).METHODS: We investigated 20 patients (11 females and 9 males; mean age 74 years, standard deviation ± 6.4 years), over a period of 18 month with the diagnosis of BRONJ in this prospective cohort study. All patients received doxycycline as a fluorescending marker for osseous structures. VELscope(®) has been used intraoperatively using the loss of fluorescence to detect presence of osteonecrosis. Osseous biopsies were taken to confirm definite histopathological diagnosis of BRONJ in each case.RESULTS: Diagnosis of BRONJ was confirmed for every patient. In all patients except one, VELscope(®) was sufficient to differentiate between healthy and necrotic bone by visual fluorescence retention (VFR) and visual fluorescence loss (VFL). 19 cases out of a total of 20 showed no signs of recurrence of BRONJ during follow-up (mean 12 months, range 4-18 months).CONCLUSION: VELscope(®) examination is a suitable tool to visualize necrotic areas of the bone in patients with bisphosphonate related osteonecrosis of the jaw. Loss of fluorescence in necrotic bone areas is useful intraoperatively as a tool for fluorescence-guided bone resection with relevant clinical interpretation.
U2 - 10.1016/j.jcms.2013.07.014
DO - 10.1016/j.jcms.2013.07.014
M3 - SCORING: Journal article
C2 - 24011463
VL - 42
SP - e157-e164
JO - J CRANIO MAXILL SURG
JF - J CRANIO MAXILL SURG
SN - 1010-5182
IS - 5
ER -