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Intermuscular adipose tissue (IMAT)

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Intermuscular adipose tissue (IMAT) : association with other adipose tissue compartments and insulin sensitivity. / Boettcher, Michael; Machann, Jürgen; Stefan, Norbert; Thamer, Claus; Häring, Hans-Ulrich; Claussen, Claus D; Fritsche, Andreas; Schick, Fritz.

In: J MAGN RESON IMAGING, Vol. 29, No. 6, 01.06.2009, p. 1340-5.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Boettcher, M, Machann, J, Stefan, N, Thamer, C, Häring, H-U, Claussen, CD, Fritsche, A & Schick, F 2009, 'Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity', J MAGN RESON IMAGING, vol. 29, no. 6, pp. 1340-5. https://doi.org/10.1002/jmri.21754

APA

Boettcher, M., Machann, J., Stefan, N., Thamer, C., Häring, H-U., Claussen, C. D., Fritsche, A., & Schick, F. (2009). Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity. J MAGN RESON IMAGING, 29(6), 1340-5. https://doi.org/10.1002/jmri.21754

Vancouver

Boettcher M, Machann J, Stefan N, Thamer C, Häring H-U, Claussen CD et al. Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity. J MAGN RESON IMAGING. 2009 Jun 1;29(6):1340-5. https://doi.org/10.1002/jmri.21754

Bibtex

@article{05cbefc230a84d0aa831a2d82fe8dda5,
title = "Intermuscular adipose tissue (IMAT): association with other adipose tissue compartments and insulin sensitivity",
abstract = "PURPOSE: To quantify intermuscular adipose tissue (IMAT) of the lower leg as well as to investigate associations with other adipose tissue (AT) compartments. The relationship between IMAT and insulin sensitivity was also examined.MATERIALS AND METHODS: Standardized quantification of IMAT was performed in a large cohort (N = 249) at increased risk for type 2 diabetes in the right calf by T1-weighted fast spin-echo imaging at 1.5T (Magnetom Sonata; Siemens Healthcare). Additionally, whole-body AT distribution was assessed. Insulin sensitivity was determined by glucose clamp.RESULTS: Males showed significantly more IMAT than females (2.1 +/- 1.1 cm(2) vs. 1.5 +/- 0.9 cm(2); P < 0.001). IMAT correlated well with other AT depots, especially with visceral AT (VAT; r(females) = 0.52, P < 0.0001 vs. r(males) = 0.42, P < 0.0001). Moreover, IMAT showed a negative correlation with the glucose infusion rate (GIR; r(females) = -0.43, P = 0.0002 vs. r(males) = -0.40, P = 0.0007).CONCLUSION: Quantification of IMAT is possible by standard MR techniques. AT distribution of the lower leg is comparable to the visceral compartment with males having higher IMAT/VAT but lower subcutaneous AT (SCAT). IMAT seems to be involved in the pathogenesis of insulin resistance, as shown by the significant negative correlation with GIR.",
keywords = "Adipose Tissue, Anthropometry, Exercise Test, Female, Glucose Clamp Technique, Humans, Image Processing, Computer-Assisted, Insulin, Intra-Abdominal Fat, Leg, Magnetic Resonance Imaging, Male, Middle Aged, Muscle, Skeletal, Sex Factors",
author = "Michael Boettcher and J{\"u}rgen Machann and Norbert Stefan and Claus Thamer and Hans-Ulrich H{\"a}ring and Claussen, {Claus D} and Andreas Fritsche and Fritz Schick",
year = "2009",
month = jun,
day = "1",
doi = "10.1002/jmri.21754",
language = "English",
volume = "29",
pages = "1340--5",
journal = "J MAGN RESON IMAGING",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Intermuscular adipose tissue (IMAT)

T2 - association with other adipose tissue compartments and insulin sensitivity

AU - Boettcher, Michael

AU - Machann, Jürgen

AU - Stefan, Norbert

AU - Thamer, Claus

AU - Häring, Hans-Ulrich

AU - Claussen, Claus D

AU - Fritsche, Andreas

AU - Schick, Fritz

PY - 2009/6/1

Y1 - 2009/6/1

N2 - PURPOSE: To quantify intermuscular adipose tissue (IMAT) of the lower leg as well as to investigate associations with other adipose tissue (AT) compartments. The relationship between IMAT and insulin sensitivity was also examined.MATERIALS AND METHODS: Standardized quantification of IMAT was performed in a large cohort (N = 249) at increased risk for type 2 diabetes in the right calf by T1-weighted fast spin-echo imaging at 1.5T (Magnetom Sonata; Siemens Healthcare). Additionally, whole-body AT distribution was assessed. Insulin sensitivity was determined by glucose clamp.RESULTS: Males showed significantly more IMAT than females (2.1 +/- 1.1 cm(2) vs. 1.5 +/- 0.9 cm(2); P < 0.001). IMAT correlated well with other AT depots, especially with visceral AT (VAT; r(females) = 0.52, P < 0.0001 vs. r(males) = 0.42, P < 0.0001). Moreover, IMAT showed a negative correlation with the glucose infusion rate (GIR; r(females) = -0.43, P = 0.0002 vs. r(males) = -0.40, P = 0.0007).CONCLUSION: Quantification of IMAT is possible by standard MR techniques. AT distribution of the lower leg is comparable to the visceral compartment with males having higher IMAT/VAT but lower subcutaneous AT (SCAT). IMAT seems to be involved in the pathogenesis of insulin resistance, as shown by the significant negative correlation with GIR.

AB - PURPOSE: To quantify intermuscular adipose tissue (IMAT) of the lower leg as well as to investigate associations with other adipose tissue (AT) compartments. The relationship between IMAT and insulin sensitivity was also examined.MATERIALS AND METHODS: Standardized quantification of IMAT was performed in a large cohort (N = 249) at increased risk for type 2 diabetes in the right calf by T1-weighted fast spin-echo imaging at 1.5T (Magnetom Sonata; Siemens Healthcare). Additionally, whole-body AT distribution was assessed. Insulin sensitivity was determined by glucose clamp.RESULTS: Males showed significantly more IMAT than females (2.1 +/- 1.1 cm(2) vs. 1.5 +/- 0.9 cm(2); P < 0.001). IMAT correlated well with other AT depots, especially with visceral AT (VAT; r(females) = 0.52, P < 0.0001 vs. r(males) = 0.42, P < 0.0001). Moreover, IMAT showed a negative correlation with the glucose infusion rate (GIR; r(females) = -0.43, P = 0.0002 vs. r(males) = -0.40, P = 0.0007).CONCLUSION: Quantification of IMAT is possible by standard MR techniques. AT distribution of the lower leg is comparable to the visceral compartment with males having higher IMAT/VAT but lower subcutaneous AT (SCAT). IMAT seems to be involved in the pathogenesis of insulin resistance, as shown by the significant negative correlation with GIR.

KW - Adipose Tissue

KW - Anthropometry

KW - Exercise Test

KW - Female

KW - Glucose Clamp Technique

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Insulin

KW - Intra-Abdominal Fat

KW - Leg

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

KW - Sex Factors

U2 - 10.1002/jmri.21754

DO - 10.1002/jmri.21754

M3 - SCORING: Journal article

C2 - 19422021

VL - 29

SP - 1340

EP - 1345

JO - J MAGN RESON IMAGING

JF - J MAGN RESON IMAGING

SN - 1053-1807

IS - 6

ER -