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Interleukin-3 is elevated in patients with coronary artery disease and predicts restenosis after percutaneous coronary intervention

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Interleukin-3 is elevated in patients with coronary artery disease and predicts restenosis after percutaneous coronary intervention. / Rudolph, Tanja; Schaps, Klaus-Peter; Steven, Daniel; Koester, Ralf; Rudolph, Volker; Berger, Juergen; Terres, Wolfram; Meinertz, Thomas; Kaehler, Jan.

In: INT J CARDIOL, Vol. 132, No. 3, 06.03.2009, p. 392-397.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rudolph, T, Schaps, K-P, Steven, D, Koester, R, Rudolph, V, Berger, J, Terres, W, Meinertz, T & Kaehler, J 2009, 'Interleukin-3 is elevated in patients with coronary artery disease and predicts restenosis after percutaneous coronary intervention', INT J CARDIOL, vol. 132, no. 3, pp. 392-397. https://doi.org/10.1016/j.ijcard.2007.12.060

APA

Rudolph, T., Schaps, K-P., Steven, D., Koester, R., Rudolph, V., Berger, J., Terres, W., Meinertz, T., & Kaehler, J. (2009). Interleukin-3 is elevated in patients with coronary artery disease and predicts restenosis after percutaneous coronary intervention. INT J CARDIOL, 132(3), 392-397. https://doi.org/10.1016/j.ijcard.2007.12.060

Vancouver

Rudolph T, Schaps K-P, Steven D, Koester R, Rudolph V, Berger J et al. Interleukin-3 is elevated in patients with coronary artery disease and predicts restenosis after percutaneous coronary intervention. INT J CARDIOL. 2009 Mar 6;132(3):392-397. https://doi.org/10.1016/j.ijcard.2007.12.060

Bibtex

@article{a0bc8a314a2f4e0491d0f73585644f92,
title = "Interleukin-3 is elevated in patients with coronary artery disease and predicts restenosis after percutaneous coronary intervention",
abstract = "BACKGROUND: Interleukin-3 (IL-3) synthesized by activated T-lymphocytes is a mediator in chronic inflammation and is suspected to promote atherosclerosis. Since there is no data on IL-3 in patients with coronary artery disease (CAD) available, we compared IL-3 concentrations in different subsets of patients with CAD to healthy control patients.METHODS: 205 consecutive patients with CAD, 136 with stable angina and 69 with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention, 61 patients with asymptomatic CAD and 41 patients with normal coronary arteries were investigated. Serum concentrations of IL-3 and hs-CRP were assessed at baseline and after 6 weeks, 6, and 12 months.RESULTS: In patients undergoing coronary angioplasty, IL-3 was detectable more frequently than in those with asymptomatic CAD or without CAD, 21 vs. 8%, p=0.02, and 21 vs. 1%, p<0.001, respectively. Patients undergoing coronary angioplasty who developed symptomatic restenosis more frequently had detectable IL-3 levels than patients without restenosis, 45 vs. 17%, p=0.02. IL-3 was the only independent predictor for restenosis in a multivariate analysis. Hs-CRP was significantly elevated in patients with ACS, 230+/-170 mg/l vs. 100+/-140 mg/l, p=0.02, but did not correlate with IL-3 concentrations at any time.CONCLUSION: IL-3, an important regulator of chronic inflammation, is elevated in patients with CAD, particularly in symptomatic patients undergoing percutaneous coronary intervention. Furthermore, high IL-3 concentrations were found to be predictive of symptomatic restenosis.",
keywords = "Acute Coronary Syndrome/blood, Angina Pectoris/blood, Angioplasty, Balloon, Coronary, C-Reactive Protein/analysis, Coronary Artery Disease/blood, Coronary Restenosis/blood, Diabetic Angiopathies/blood, Disease Progression, Humans, Interleukin-3/blood, Multivariate Analysis",
author = "Tanja Rudolph and Klaus-Peter Schaps and Daniel Steven and Ralf Koester and Volker Rudolph and Juergen Berger and Wolfram Terres and Thomas Meinertz and Jan Kaehler",
year = "2009",
month = mar,
day = "6",
doi = "10.1016/j.ijcard.2007.12.060",
language = "English",
volume = "132",
pages = "392--397",
journal = "INT J CARDIOL",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Interleukin-3 is elevated in patients with coronary artery disease and predicts restenosis after percutaneous coronary intervention

AU - Rudolph, Tanja

AU - Schaps, Klaus-Peter

AU - Steven, Daniel

AU - Koester, Ralf

AU - Rudolph, Volker

AU - Berger, Juergen

AU - Terres, Wolfram

AU - Meinertz, Thomas

AU - Kaehler, Jan

PY - 2009/3/6

Y1 - 2009/3/6

N2 - BACKGROUND: Interleukin-3 (IL-3) synthesized by activated T-lymphocytes is a mediator in chronic inflammation and is suspected to promote atherosclerosis. Since there is no data on IL-3 in patients with coronary artery disease (CAD) available, we compared IL-3 concentrations in different subsets of patients with CAD to healthy control patients.METHODS: 205 consecutive patients with CAD, 136 with stable angina and 69 with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention, 61 patients with asymptomatic CAD and 41 patients with normal coronary arteries were investigated. Serum concentrations of IL-3 and hs-CRP were assessed at baseline and after 6 weeks, 6, and 12 months.RESULTS: In patients undergoing coronary angioplasty, IL-3 was detectable more frequently than in those with asymptomatic CAD or without CAD, 21 vs. 8%, p=0.02, and 21 vs. 1%, p<0.001, respectively. Patients undergoing coronary angioplasty who developed symptomatic restenosis more frequently had detectable IL-3 levels than patients without restenosis, 45 vs. 17%, p=0.02. IL-3 was the only independent predictor for restenosis in a multivariate analysis. Hs-CRP was significantly elevated in patients with ACS, 230+/-170 mg/l vs. 100+/-140 mg/l, p=0.02, but did not correlate with IL-3 concentrations at any time.CONCLUSION: IL-3, an important regulator of chronic inflammation, is elevated in patients with CAD, particularly in symptomatic patients undergoing percutaneous coronary intervention. Furthermore, high IL-3 concentrations were found to be predictive of symptomatic restenosis.

AB - BACKGROUND: Interleukin-3 (IL-3) synthesized by activated T-lymphocytes is a mediator in chronic inflammation and is suspected to promote atherosclerosis. Since there is no data on IL-3 in patients with coronary artery disease (CAD) available, we compared IL-3 concentrations in different subsets of patients with CAD to healthy control patients.METHODS: 205 consecutive patients with CAD, 136 with stable angina and 69 with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention, 61 patients with asymptomatic CAD and 41 patients with normal coronary arteries were investigated. Serum concentrations of IL-3 and hs-CRP were assessed at baseline and after 6 weeks, 6, and 12 months.RESULTS: In patients undergoing coronary angioplasty, IL-3 was detectable more frequently than in those with asymptomatic CAD or without CAD, 21 vs. 8%, p=0.02, and 21 vs. 1%, p<0.001, respectively. Patients undergoing coronary angioplasty who developed symptomatic restenosis more frequently had detectable IL-3 levels than patients without restenosis, 45 vs. 17%, p=0.02. IL-3 was the only independent predictor for restenosis in a multivariate analysis. Hs-CRP was significantly elevated in patients with ACS, 230+/-170 mg/l vs. 100+/-140 mg/l, p=0.02, but did not correlate with IL-3 concentrations at any time.CONCLUSION: IL-3, an important regulator of chronic inflammation, is elevated in patients with CAD, particularly in symptomatic patients undergoing percutaneous coronary intervention. Furthermore, high IL-3 concentrations were found to be predictive of symptomatic restenosis.

KW - Acute Coronary Syndrome/blood

KW - Angina Pectoris/blood

KW - Angioplasty, Balloon, Coronary

KW - C-Reactive Protein/analysis

KW - Coronary Artery Disease/blood

KW - Coronary Restenosis/blood

KW - Diabetic Angiopathies/blood

KW - Disease Progression

KW - Humans

KW - Interleukin-3/blood

KW - Multivariate Analysis

U2 - 10.1016/j.ijcard.2007.12.060

DO - 10.1016/j.ijcard.2007.12.060

M3 - SCORING: Journal article

C2 - 18378332

VL - 132

SP - 392

EP - 397

JO - INT J CARDIOL

JF - INT J CARDIOL

SN - 0167-5273

IS - 3

ER -