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Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

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Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. / Li, Shun; Olde Heuvel, Florian; Rehman, Rida; Aousji, Oumayma; Froehlich, Albrecht; Li, Zhenghui; Jark, Rebecca; Zhang, Wanhong; Conquest, Alison; Woelfle, Sarah; Schoen, Michael; O Meara, Caitlin C; Reinhardt, Richard Lee; Voehringer, David; Kassubek, Jan; Ludolph, Albert; Huber-Lang, Markus; Knöll, Bernd; Morganti-Kossmann, Maria Cristina; Brockmann, Marisa M; Boeckers, Tobias; Roselli, Francesco.

In: NAT COMMUN, Vol. 14, No. 1, 200, 13.01.2023.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Li, S, Olde Heuvel, F, Rehman, R, Aousji, O, Froehlich, A, Li, Z, Jark, R, Zhang, W, Conquest, A, Woelfle, S, Schoen, M, O Meara, CC, Reinhardt, RL, Voehringer, D, Kassubek, J, Ludolph, A, Huber-Lang, M, Knöll, B, Morganti-Kossmann, MC, Brockmann, MM, Boeckers, T & Roselli, F 2023, 'Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection', NAT COMMUN, vol. 14, no. 1, 200. https://doi.org/10.1038/s41467-023-35806-8

APA

Li, S., Olde Heuvel, F., Rehman, R., Aousji, O., Froehlich, A., Li, Z., Jark, R., Zhang, W., Conquest, A., Woelfle, S., Schoen, M., O Meara, C. C., Reinhardt, R. L., Voehringer, D., Kassubek, J., Ludolph, A., Huber-Lang, M., Knöll, B., Morganti-Kossmann, M. C., ... Roselli, F. (2023). Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. NAT COMMUN, 14(1), [200]. https://doi.org/10.1038/s41467-023-35806-8

Vancouver

Li S, Olde Heuvel F, Rehman R, Aousji O, Froehlich A, Li Z et al. Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. NAT COMMUN. 2023 Jan 13;14(1). 200. https://doi.org/10.1038/s41467-023-35806-8

Bibtex

@article{92c704c39e9547d3a365a502256b29f0,
title = "Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection",
abstract = "Immune system molecules are expressed by neurons, yet their functions are often unknown. We have identified IL-13 and its receptor IL-13Ra1 as neuronal, synaptic proteins in mouse, rat, and human brains, whose engagement upregulates the phosphorylation of NMDAR and AMPAR subunits and, in turn, increases synaptic activity and CREB-mediated transcription. We demonstrate that increased IL-13 is a hallmark of traumatic brain injury (TBI) in male mice as well as in two distinct cohorts of human patients. We also provide evidence that IL-13 upregulation protects neurons from excitotoxic death. We show IL-13 upregulation occurring in several cohorts of human brain samples and in cerebrospinal fluid (CSF). Thus, IL-13 is a physiological modulator of synaptic physiology of neuronal origin, with implications for the establishment of synaptic plasticity and the survival of neurons under injury conditions. Furthermore, we suggest that the neuroprotection afforded through the upregulation of IL-13 represents an entry point for interventions in the pathophysiology of TBI.",
keywords = "Animals, Humans, Male, Mice, Rats, Brain Injuries, Traumatic/genetics, Interleukin-13/genetics, Neuronal Plasticity/physiology, Neurons/metabolism, Neuroprotection",
author = "Shun Li and {Olde Heuvel}, Florian and Rida Rehman and Oumayma Aousji and Albrecht Froehlich and Zhenghui Li and Rebecca Jark and Wanhong Zhang and Alison Conquest and Sarah Woelfle and Michael Schoen and {O Meara}, {Caitlin C} and Reinhardt, {Richard Lee} and David Voehringer and Jan Kassubek and Albert Ludolph and Markus Huber-Lang and Bernd Kn{\"o}ll and Morganti-Kossmann, {Maria Cristina} and Brockmann, {Marisa M} and Tobias Boeckers and Francesco Roselli",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = jan,
day = "13",
doi = "10.1038/s41467-023-35806-8",
language = "English",
volume = "14",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection

AU - Li, Shun

AU - Olde Heuvel, Florian

AU - Rehman, Rida

AU - Aousji, Oumayma

AU - Froehlich, Albrecht

AU - Li, Zhenghui

AU - Jark, Rebecca

AU - Zhang, Wanhong

AU - Conquest, Alison

AU - Woelfle, Sarah

AU - Schoen, Michael

AU - O Meara, Caitlin C

AU - Reinhardt, Richard Lee

AU - Voehringer, David

AU - Kassubek, Jan

AU - Ludolph, Albert

AU - Huber-Lang, Markus

AU - Knöll, Bernd

AU - Morganti-Kossmann, Maria Cristina

AU - Brockmann, Marisa M

AU - Boeckers, Tobias

AU - Roselli, Francesco

N1 - © 2023. The Author(s).

PY - 2023/1/13

Y1 - 2023/1/13

N2 - Immune system molecules are expressed by neurons, yet their functions are often unknown. We have identified IL-13 and its receptor IL-13Ra1 as neuronal, synaptic proteins in mouse, rat, and human brains, whose engagement upregulates the phosphorylation of NMDAR and AMPAR subunits and, in turn, increases synaptic activity and CREB-mediated transcription. We demonstrate that increased IL-13 is a hallmark of traumatic brain injury (TBI) in male mice as well as in two distinct cohorts of human patients. We also provide evidence that IL-13 upregulation protects neurons from excitotoxic death. We show IL-13 upregulation occurring in several cohorts of human brain samples and in cerebrospinal fluid (CSF). Thus, IL-13 is a physiological modulator of synaptic physiology of neuronal origin, with implications for the establishment of synaptic plasticity and the survival of neurons under injury conditions. Furthermore, we suggest that the neuroprotection afforded through the upregulation of IL-13 represents an entry point for interventions in the pathophysiology of TBI.

AB - Immune system molecules are expressed by neurons, yet their functions are often unknown. We have identified IL-13 and its receptor IL-13Ra1 as neuronal, synaptic proteins in mouse, rat, and human brains, whose engagement upregulates the phosphorylation of NMDAR and AMPAR subunits and, in turn, increases synaptic activity and CREB-mediated transcription. We demonstrate that increased IL-13 is a hallmark of traumatic brain injury (TBI) in male mice as well as in two distinct cohorts of human patients. We also provide evidence that IL-13 upregulation protects neurons from excitotoxic death. We show IL-13 upregulation occurring in several cohorts of human brain samples and in cerebrospinal fluid (CSF). Thus, IL-13 is a physiological modulator of synaptic physiology of neuronal origin, with implications for the establishment of synaptic plasticity and the survival of neurons under injury conditions. Furthermore, we suggest that the neuroprotection afforded through the upregulation of IL-13 represents an entry point for interventions in the pathophysiology of TBI.

KW - Animals

KW - Humans

KW - Male

KW - Mice

KW - Rats

KW - Brain Injuries, Traumatic/genetics

KW - Interleukin-13/genetics

KW - Neuronal Plasticity/physiology

KW - Neurons/metabolism

KW - Neuroprotection

U2 - 10.1038/s41467-023-35806-8

DO - 10.1038/s41467-023-35806-8

M3 - SCORING: Journal article

C2 - 36639371

VL - 14

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

M1 - 200

ER -