Interactive real-time mapping and catheter ablation of the cavotricuspid isthmus guided by magnetic resonance imaging in a porcine model
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Interactive real-time mapping and catheter ablation of the cavotricuspid isthmus guided by magnetic resonance imaging in a porcine model. / Hoffmann, Boris A; Koops, Andreas; Rostock, Thomas; Müllerleile, Kai; Steven, Daniel; Karst, Roman; Steinke, Mark U; Drewitz, Imke; Lund, Gunnar; Koops, Susan; Adam, Gerhard; Willems, Stephan.
In: EUR HEART J, Vol. 31, No. 4, 02.2010, p. 450-456.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Interactive real-time mapping and catheter ablation of the cavotricuspid isthmus guided by magnetic resonance imaging in a porcine model
AU - Hoffmann, Boris A
AU - Koops, Andreas
AU - Rostock, Thomas
AU - Müllerleile, Kai
AU - Steven, Daniel
AU - Karst, Roman
AU - Steinke, Mark U
AU - Drewitz, Imke
AU - Lund, Gunnar
AU - Koops, Susan
AU - Adam, Gerhard
AU - Willems, Stephan
PY - 2010/2
Y1 - 2010/2
N2 - Aims We investigated the feasibility of real-time magnetic resonance imaging (RTMRI) guided ablation of the cavotricuspid isthmus (CTI) by using a MRI-compatible ablation catheter. Methods and results Cavotricuspid isthmus ablation was performed in an interventional RTMRI suite by using a novel 7 French, steerable, non-ferromagnetic ablation catheter in a porcine in vivo model (n = 20). The catheter was introduced and navigated by RTMRI visualization only. Catheter position and movement during manipulation were continuously visualized during the entire intervention. Two porcine prematurely died due to VT/VF. Anatomical completion of the CTI ablation line could be achieved after a mean of 6.3+/-3 RF pulses (RF energy: 1807+/-1016.4 Ws/RF pulse, temperature: 55.9+/-5.9 degrees C) in n = 18 animals. In 15 of 18 procedures (83.3%) a complete CTI block was proven by conventional mapping in the electrophysiological (EP) lab. Conclusion Completely non-fluoroscopic ablation guided by RTMRI using a steerable and non-ferromagnetic catheter is a promising novel technology in interventional electrophysiology.
AB - Aims We investigated the feasibility of real-time magnetic resonance imaging (RTMRI) guided ablation of the cavotricuspid isthmus (CTI) by using a MRI-compatible ablation catheter. Methods and results Cavotricuspid isthmus ablation was performed in an interventional RTMRI suite by using a novel 7 French, steerable, non-ferromagnetic ablation catheter in a porcine in vivo model (n = 20). The catheter was introduced and navigated by RTMRI visualization only. Catheter position and movement during manipulation were continuously visualized during the entire intervention. Two porcine prematurely died due to VT/VF. Anatomical completion of the CTI ablation line could be achieved after a mean of 6.3+/-3 RF pulses (RF energy: 1807+/-1016.4 Ws/RF pulse, temperature: 55.9+/-5.9 degrees C) in n = 18 animals. In 15 of 18 procedures (83.3%) a complete CTI block was proven by conventional mapping in the electrophysiological (EP) lab. Conclusion Completely non-fluoroscopic ablation guided by RTMRI using a steerable and non-ferromagnetic catheter is a promising novel technology in interventional electrophysiology.
KW - Animals
KW - Atrial Flutter/surgery
KW - Catheter Ablation/methods
KW - Electrophysiology
KW - Feasibility Studies
KW - Magnetic Resonance Angiography
KW - Magnetic Resonance Imaging, Interventional
KW - Swine
KW - Tricuspid Valve/surgery
U2 - 10.1093/eurheartj/ehp460
DO - 10.1093/eurheartj/ehp460
M3 - SCORING: Journal article
C2 - 19897495
VL - 31
SP - 450
EP - 456
JO - EUR HEART J
JF - EUR HEART J
SN - 0195-668X
IS - 4
ER -
