Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space.

Chun Han; Denan Wang; Peter Soba; Sijun Zhu; Xinhua Lin; Lily Yeh Jan; Yuh-Nung Jan

Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space.

Standard

Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. / Han, Chun; Wang, Denan; Soba, Peter; Zhu, Sijun; Lin, Xinhua; Jan, Lily Yeh; Jan, Yuh-Nung.

In: NEURON, Vol. 73, No. 1, 1, 2012, p. 64-78.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Han, C, Wang, D, Soba, P, Zhu, S, Lin, X, Jan, LY & Jan, Y-N 2012, 'Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space.', NEURON, vol. 73, no. 1, 1, pp. 64-78. <http://www.ncbi.nlm.nih.gov/pubmed/22243747?dopt=Citation>

APA

Han, C., Wang, D., Soba, P., Zhu, S., Lin, X., Jan, L. Y., & Jan, Y-N. (2012). Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. NEURON, 73(1), 64-78. [1]. http://www.ncbi.nlm.nih.gov/pubmed/22243747?dopt=Citation

Vancouver

Han C, Wang D, Soba P, Zhu S, Lin X, Jan LY et al. Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space. NEURON. 2012;73(1):64-78. 1.

Bibtex

@article{84637b752707433da918a05652abcac7,

title = "Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space.",

abstract = "Dendrites of the same neuron usually avoid each other. Some neurons also repel similar neurons through dendrite-dendrite interaction to tile the receptive field. Nonoverlapping coverage based on such contact-dependent repulsion requires dendrites to compete for limited space. Here we show that Drosophila class IV dendritic arborization (da) neurons, which tile the larval body wall, grow their dendrites mainly in a 2D space on the extracellular matrix (ECM) secreted by the epidermis. Removing neuronal integrins or blocking epidermal laminin production causes dendrites to grow into the epidermis, suggesting that integrin-laminin interaction attaches dendrites to the ECM. We further show that some of the previously identified tiling mutants fail to confine dendrites in a 2D plane. Expansion of these mutant dendrites in three dimensions results in overlap of dendritic fields. Moreover, overexpression of integrins in these mutant neurons effectively reduces dendritic crossing and restores tiling, revealing an additional mechanism for tiling.",

keywords = "Animals, Signal Transduction, Microscopy, Electron, Transmission, Cloning, Molecular, Animals, Genetically Modified, Mutation/genetics, RNA Interference, Neuroimaging, Dendrites/*physiology/ultrastructure, Drosophila, Drosophila Proteins/genetics, Embryo, Nonmammalian, Extracellular Matrix/physiology, Gene Expression Regulation, Developmental/genetics/*physiology, Integrins/genetics/*physiology, Laminin/metabolism, Sense Organs/cytology, Sensory Receptor Cells/*cytology/metabolism, Animals, Signal Transduction, Microscopy, Electron, Transmission, Cloning, Molecular, Animals, Genetically Modified, Mutation/genetics, RNA Interference, Neuroimaging, Dendrites/*physiology/ultrastructure, Drosophila, Drosophila Proteins/genetics, Embryo, Nonmammalian, Extracellular Matrix/physiology, Gene Expression Regulation, Developmental/genetics/*physiology, Integrins/genetics/*physiology, Laminin/metabolism, Sense Organs/cytology, Sensory Receptor Cells/*cytology/metabolism",

author = "Chun Han and Denan Wang and Peter Soba and Sijun Zhu and Xinhua Lin and Jan, {Lily Yeh} and Yuh-Nung Jan",

year = "2012",

language = "English",

volume = "73",

pages = "64--78",

journal = "NEURON",

issn = "0896-6273",

publisher = "Cell Press",

number = "1",

}

RIS

TY - JOUR

T1 - Integrins regulate repulsion-mediated dendritic patterning of drosophila sensory neurons by restricting dendrites in a 2D space.

AU - Han, Chun

AU - Wang, Denan

AU - Soba, Peter

AU - Zhu, Sijun

AU - Lin, Xinhua

AU - Jan, Lily Yeh

AU - Jan, Yuh-Nung

PY - 2012

Y1 - 2012

N2 - Dendrites of the same neuron usually avoid each other. Some neurons also repel similar neurons through dendrite-dendrite interaction to tile the receptive field. Nonoverlapping coverage based on such contact-dependent repulsion requires dendrites to compete for limited space. Here we show that Drosophila class IV dendritic arborization (da) neurons, which tile the larval body wall, grow their dendrites mainly in a 2D space on the extracellular matrix (ECM) secreted by the epidermis. Removing neuronal integrins or blocking epidermal laminin production causes dendrites to grow into the epidermis, suggesting that integrin-laminin interaction attaches dendrites to the ECM. We further show that some of the previously identified tiling mutants fail to confine dendrites in a 2D plane. Expansion of these mutant dendrites in three dimensions results in overlap of dendritic fields. Moreover, overexpression of integrins in these mutant neurons effectively reduces dendritic crossing and restores tiling, revealing an additional mechanism for tiling.

AB - Dendrites of the same neuron usually avoid each other. Some neurons also repel similar neurons through dendrite-dendrite interaction to tile the receptive field. Nonoverlapping coverage based on such contact-dependent repulsion requires dendrites to compete for limited space. Here we show that Drosophila class IV dendritic arborization (da) neurons, which tile the larval body wall, grow their dendrites mainly in a 2D space on the extracellular matrix (ECM) secreted by the epidermis. Removing neuronal integrins or blocking epidermal laminin production causes dendrites to grow into the epidermis, suggesting that integrin-laminin interaction attaches dendrites to the ECM. We further show that some of the previously identified tiling mutants fail to confine dendrites in a 2D plane. Expansion of these mutant dendrites in three dimensions results in overlap of dendritic fields. Moreover, overexpression of integrins in these mutant neurons effectively reduces dendritic crossing and restores tiling, revealing an additional mechanism for tiling.

KW - Animals

KW - Signal Transduction

KW - Microscopy, Electron, Transmission

KW - Cloning, Molecular

KW - Animals, Genetically Modified

KW - Mutation/genetics

KW - RNA Interference

KW - Neuroimaging

KW - Dendrites/physiology/ultrastructure

KW - Drosophila

KW - Drosophila Proteins/genetics

KW - Embryo, Nonmammalian

KW - Extracellular Matrix/physiology

KW - Gene Expression Regulation, Developmental/genetics/physiology

KW - Integrins/genetics/physiology

KW - Laminin/metabolism

KW - Sense Organs/cytology

KW - Sensory Receptor Cells/cytology/metabolism

KW - Animals

KW - Signal Transduction

KW - Microscopy, Electron, Transmission

KW - Cloning, Molecular

KW - Animals, Genetically Modified

KW - Mutation/genetics

KW - RNA Interference

KW - Neuroimaging

KW - Dendrites/physiology/ultrastructure

KW - Drosophila

KW - Drosophila Proteins/genetics

KW - Embryo, Nonmammalian

KW - Extracellular Matrix/physiology

KW - Gene Expression Regulation, Developmental/genetics/physiology

KW - Integrins/genetics/physiology

KW - Laminin/metabolism

KW - Sense Organs/cytology

KW - Sensory Receptor Cells/cytology/metabolism

M3 - SCORING: Journal article

VL - 73

SP - 64

EP - 78

JO - NEURON

JF - NEURON

SN - 0896-6273

IS - 1

M1 - 1

ER -