Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus.
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Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus. / Kalinina, Tatiana; Bockhorn, Maximilian; Kaifi, Jussuf; Thieltges, Sabrina; Güngör, Cenap; Harms-Effenberger, Katharina; Strelow, Andrea; Reichelt, Uta; Sauter, Guido; Pantel, Klaus; Izbicki, Jakob R.; Yekebas, Emre F.
In: INT J CANCER, Vol. 127, No. 8, 8, 2010, p. 1931-1940.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus.
AU - Kalinina, Tatiana
AU - Bockhorn, Maximilian
AU - Kaifi, Jussuf
AU - Thieltges, Sabrina
AU - Güngör, Cenap
AU - Harms-Effenberger, Katharina
AU - Strelow, Andrea
AU - Reichelt, Uta
AU - Sauter, Guido
AU - Pantel, Klaus
AU - Izbicki, Jakob R.
AU - Yekebas, Emre F.
PY - 2010
Y1 - 2010
N2 - Insulin-like growth factor-1 receptor (IGF-1R) and HER2 receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer, and to determine the effect of IGF-1R and HER2 targeting with alpha-IR3 and Herceptin antibodies on the proliferation of esophageal cancer cells in vitro.IGF-1R expression and clinico-pathological correlations were analyzed with a tissue micro array containing 234 esophageal cancer specimens (131 adeno-, 101 squamous cell carcinomas). Proliferation changes associated with Herceptin and alpha-IR3 blockage were evaluated with the unique human esophageal cancer cell lines Pt1590 and LN1590. IGF-1R and HER2 expression levels, activation and phosphorylation status of downstream signalling proteins involved in the activation pathways were analyzed by Western blotting.IGF-1R overexpression was detected in 121 (52%) of the 234 esophageal tumors examined. In the subgroup of 87 HER2-positive tumors, 93.1% showed concordant overexpression for IGF-1R. IGF-1R was identified as a variable associated with reduced overall survival for adenocarcinoma (P=0.05), but not for squamous cell carcinoma. The combination of Herceptin and alpha-IR3 was more effective in inhibiting in vitro proliferation than treatment with either agent alone (P
AB - Insulin-like growth factor-1 receptor (IGF-1R) and HER2 receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer, and to determine the effect of IGF-1R and HER2 targeting with alpha-IR3 and Herceptin antibodies on the proliferation of esophageal cancer cells in vitro.IGF-1R expression and clinico-pathological correlations were analyzed with a tissue micro array containing 234 esophageal cancer specimens (131 adeno-, 101 squamous cell carcinomas). Proliferation changes associated with Herceptin and alpha-IR3 blockage were evaluated with the unique human esophageal cancer cell lines Pt1590 and LN1590. IGF-1R and HER2 expression levels, activation and phosphorylation status of downstream signalling proteins involved in the activation pathways were analyzed by Western blotting.IGF-1R overexpression was detected in 121 (52%) of the 234 esophageal tumors examined. In the subgroup of 87 HER2-positive tumors, 93.1% showed concordant overexpression for IGF-1R. IGF-1R was identified as a variable associated with reduced overall survival for adenocarcinoma (P=0.05), but not for squamous cell carcinoma. The combination of Herceptin and alpha-IR3 was more effective in inhibiting in vitro proliferation than treatment with either agent alone (P
M3 - SCORING: Zeitschriftenaufsatz
VL - 127
SP - 1931
EP - 1940
JO - INT J CANCER
JF - INT J CANCER
SN - 0020-7136
IS - 8
M1 - 8
ER -
