Research ExplorerPublicationsInsulin resistance and atrial fibrillation (from the Framing...

Insulin resistance and atrial fibrillation (from the Framingham Heart Study)

Standard

Insulin resistance and atrial fibrillation (from the Framingham Heart Study). / Fontes, João D; Lyass, Asya; Massaro, Joseph M; Rienstra, Michiel; Dallmeier, Dhayana; Schnabel, Renate B; Wang, Thomas J; Vasan, Ramachandran S; Lubitz, Steven A; Magnani, Jared W; Levy, Daniel; Ellinor, Patrick T; Fox, Caroline S; Benjamin, Emelia J.

In: AM J CARDIOL, Vol. 109, No. 1, 01.01.2012, p. 87-90.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Fontes, JD, Lyass, A, Massaro, JM, Rienstra, M, Dallmeier, D, Schnabel, RB, Wang, TJ, Vasan, RS, Lubitz, SA, Magnani, JW, Levy, D, Ellinor, PT, Fox, CS & Benjamin, EJ 2012, 'Insulin resistance and atrial fibrillation (from the Framingham Heart Study)', AM J CARDIOL, vol. 109, no. 1, pp. 87-90. https://doi.org/10.1016/j.amjcard.2011.08.008

APA

Fontes, J. D., Lyass, A., Massaro, J. M., Rienstra, M., Dallmeier, D., Schnabel, R. B., Wang, T. J., Vasan, R. S., Lubitz, S. A., Magnani, J. W., Levy, D., Ellinor, P. T., Fox, C. S., & Benjamin, E. J. (2012). Insulin resistance and atrial fibrillation (from the Framingham Heart Study). AM J CARDIOL, 109(1), 87-90. https://doi.org/10.1016/j.amjcard.2011.08.008

Vancouver

Fontes JD, Lyass A, Massaro JM, Rienstra M, Dallmeier D, Schnabel RB et al. Insulin resistance and atrial fibrillation (from the Framingham Heart Study). AM J CARDIOL. 2012 Jan 1;109(1):87-90. https://doi.org/10.1016/j.amjcard.2011.08.008

Bibtex

@article{4e873f8e710444cfa088612b992c442b,
title = "Insulin resistance and atrial fibrillation (from the Framingham Heart Study)",
abstract = "Diabetes mellitus and obesity are increasing in prevalence and are associated with an elevated risk of atrial fibrillation (AF). Given the aging of the United States population, AF is projected to concomitantly increase in prevalence in the upcoming decades. Both diabetes and obesity are associated with insulin resistance. Whether insulin resistance is an intermediate step for the development of AF is uncertain. We hypothesized that insulin resistance is associated with an increased risk of incident AF. We examined the association of insulin resistance with incident AF using multivariate Cox proportional hazards regression analysis adjusting for the established AF risk factors (i.e., age, gender, systolic blood pressure, hypertension treatment, PR interval, significant heart murmur, heart failure, and body mass index). Of the 3,023 eligible participants (55% women; mean age 59 years) representing 4,583 person-examinations (Framingham Offspring fifth and seventh examination cycles), 279 participants developed AF (9.3%) within ≤10 years of follow-up. With multivariate modeling, insulin resistance was not significantly associated with incident AF (hazard ratio comparing top quartile to other 3 quartiles of homeostatic model assessment index 1.18, 95% confidence interval 0.84 to 1.65, p = 0.34). In a community-based cohort with ≤10 years of follow-up, no significant association was observed between insulin resistance and incident AF.",
keywords = "Aged, Atrial Fibrillation/blood, Blood Glucose/metabolism, Body Mass Index, Confidence Intervals, Female, Follow-Up Studies, Humans, Incidence, Insulin/blood, Insulin Resistance, Male, Massachusetts/epidemiology, Metabolic Syndrome/blood, Proportional Hazards Models, Retrospective Studies, Risk Factors",
author = "Fontes, {Jo{\~a}o D} and Asya Lyass and Massaro, {Joseph M} and Michiel Rienstra and Dhayana Dallmeier and Schnabel, {Renate B} and Wang, {Thomas J} and Vasan, {Ramachandran S} and Lubitz, {Steven A} and Magnani, {Jared W} and Daniel Levy and Ellinor, {Patrick T} and Fox, {Caroline S} and Benjamin, {Emelia J}",
note = "Copyright {\textcopyright} 2012 Elsevier Inc. All rights reserved.",
year = "2012",
month = jan,
day = "1",
doi = "10.1016/j.amjcard.2011.08.008",
language = "English",
volume = "109",
pages = "87--90",
journal = "AM J CARDIOL",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Insulin resistance and atrial fibrillation (from the Framingham Heart Study)

AU - Fontes, João D

AU - Lyass, Asya

AU - Massaro, Joseph M

AU - Rienstra, Michiel

AU - Dallmeier, Dhayana

AU - Schnabel, Renate B

AU - Wang, Thomas J

AU - Vasan, Ramachandran S

AU - Lubitz, Steven A

AU - Magnani, Jared W

AU - Levy, Daniel

AU - Ellinor, Patrick T

AU - Fox, Caroline S

AU - Benjamin, Emelia J

N1 - Copyright © 2012 Elsevier Inc. All rights reserved.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Diabetes mellitus and obesity are increasing in prevalence and are associated with an elevated risk of atrial fibrillation (AF). Given the aging of the United States population, AF is projected to concomitantly increase in prevalence in the upcoming decades. Both diabetes and obesity are associated with insulin resistance. Whether insulin resistance is an intermediate step for the development of AF is uncertain. We hypothesized that insulin resistance is associated with an increased risk of incident AF. We examined the association of insulin resistance with incident AF using multivariate Cox proportional hazards regression analysis adjusting for the established AF risk factors (i.e., age, gender, systolic blood pressure, hypertension treatment, PR interval, significant heart murmur, heart failure, and body mass index). Of the 3,023 eligible participants (55% women; mean age 59 years) representing 4,583 person-examinations (Framingham Offspring fifth and seventh examination cycles), 279 participants developed AF (9.3%) within ≤10 years of follow-up. With multivariate modeling, insulin resistance was not significantly associated with incident AF (hazard ratio comparing top quartile to other 3 quartiles of homeostatic model assessment index 1.18, 95% confidence interval 0.84 to 1.65, p = 0.34). In a community-based cohort with ≤10 years of follow-up, no significant association was observed between insulin resistance and incident AF.

AB - Diabetes mellitus and obesity are increasing in prevalence and are associated with an elevated risk of atrial fibrillation (AF). Given the aging of the United States population, AF is projected to concomitantly increase in prevalence in the upcoming decades. Both diabetes and obesity are associated with insulin resistance. Whether insulin resistance is an intermediate step for the development of AF is uncertain. We hypothesized that insulin resistance is associated with an increased risk of incident AF. We examined the association of insulin resistance with incident AF using multivariate Cox proportional hazards regression analysis adjusting for the established AF risk factors (i.e., age, gender, systolic blood pressure, hypertension treatment, PR interval, significant heart murmur, heart failure, and body mass index). Of the 3,023 eligible participants (55% women; mean age 59 years) representing 4,583 person-examinations (Framingham Offspring fifth and seventh examination cycles), 279 participants developed AF (9.3%) within ≤10 years of follow-up. With multivariate modeling, insulin resistance was not significantly associated with incident AF (hazard ratio comparing top quartile to other 3 quartiles of homeostatic model assessment index 1.18, 95% confidence interval 0.84 to 1.65, p = 0.34). In a community-based cohort with ≤10 years of follow-up, no significant association was observed between insulin resistance and incident AF.

KW - Aged

KW - Atrial Fibrillation/blood

KW - Blood Glucose/metabolism

KW - Body Mass Index

KW - Confidence Intervals

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Insulin/blood

KW - Insulin Resistance

KW - Male

KW - Massachusetts/epidemiology

KW - Metabolic Syndrome/blood

KW - Proportional Hazards Models

KW - Retrospective Studies

KW - Risk Factors

U2 - 10.1016/j.amjcard.2011.08.008

DO - 10.1016/j.amjcard.2011.08.008

M3 - SCORING: Journal article

C2 - 21996140

VL - 109

SP - 87

EP - 90

JO - AM J CARDIOL

JF - AM J CARDIOL

SN - 0002-9149

IS - 1

ER -