Insula and sensory insular cortex and somatosensory control in patients with insular stroke
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Insula and sensory insular cortex and somatosensory control in patients with insular stroke. / Baier, B; zu Eulenburg, P; Geber, C; Rohde, F; Rolke, R; Maihöfner, C; Birklein, F; Dieterich, M.
In: EUR J PAIN, Vol. 18, No. 10, 11.2014, p. 1385-93.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Insula and sensory insular cortex and somatosensory control in patients with insular stroke
AU - Baier, B
AU - zu Eulenburg, P
AU - Geber, C
AU - Rohde, F
AU - Rolke, R
AU - Maihöfner, C
AU - Birklein, F
AU - Dieterich, M
N1 - © 2014 European Pain Federation - EFIC®
PY - 2014/11
Y1 - 2014/11
N2 - BACKGROUND: In functional imaging studies, the insular cortex (IC) has been identified as an essential part of the processing of a whole spectrum of multimodal sensory input. However, there are no lesion studies including a sufficient number of patients, which would reinforce the functional imaging data obtained from healthy subjects. Such lesion studies should examine how damage to the IC affects sensory perception. We chose acute stroke patients with lesions affecting the IC in order to fill this gap.METHODS: A comprehensive sensory profiling by applying a quantitative sensory testing protocol was performed and a voxel-lesion behaviour mapping analysis in 24 patients with acute unilateral cortical damage was applied.RESULTS: Our data demonstrate that patients with lesions of the posterior IC have deficits in temperature perception, but did not show other sensory deficits such as hot or cold pain perception associated with specific lesion locations.CONCLUSION: Our data allow the conclusion that the posterior IC may represent the major region responsible for encoding warm and cold perception in the brain. To what extent focal IC lesions may also impair pain processing or induce post-stroke pain has to be addressed in future studies including more patients.
AB - BACKGROUND: In functional imaging studies, the insular cortex (IC) has been identified as an essential part of the processing of a whole spectrum of multimodal sensory input. However, there are no lesion studies including a sufficient number of patients, which would reinforce the functional imaging data obtained from healthy subjects. Such lesion studies should examine how damage to the IC affects sensory perception. We chose acute stroke patients with lesions affecting the IC in order to fill this gap.METHODS: A comprehensive sensory profiling by applying a quantitative sensory testing protocol was performed and a voxel-lesion behaviour mapping analysis in 24 patients with acute unilateral cortical damage was applied.RESULTS: Our data demonstrate that patients with lesions of the posterior IC have deficits in temperature perception, but did not show other sensory deficits such as hot or cold pain perception associated with specific lesion locations.CONCLUSION: Our data allow the conclusion that the posterior IC may represent the major region responsible for encoding warm and cold perception in the brain. To what extent focal IC lesions may also impair pain processing or induce post-stroke pain has to be addressed in future studies including more patients.
KW - Aged
KW - Brain Mapping
KW - Cerebral Cortex
KW - Cohort Studies
KW - Female
KW - Humans
KW - Hypesthesia
KW - Magnetic Resonance Imaging
KW - Male
KW - Middle Aged
KW - Pain Perception
KW - Perception
KW - Somatosensory Cortex
KW - Stroke
KW - Thermosensing
KW - Touch Perception
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1002/j.1532-2149.2014.501.x
DO - 10.1002/j.1532-2149.2014.501.x
M3 - SCORING: Journal article
C2 - 24687886
VL - 18
SP - 1385
EP - 1393
JO - EUR J PAIN
JF - EUR J PAIN
SN - 1090-3801
IS - 10
ER -