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In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids

Standard

In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids. / Körnig, Christian; Staufer, Theresa; Schmutzler, Oliver; Bedke, Tanja; Machicote, Andres; Liu, Beibei; Liu, Yang; Gargioni, Elisabetta; Feliu, Neus; Parak, Wolfgang J; Huber, Samuel; Grüner, Florian.

In: SCI REP-UK, Vol. 12, No. 1, 21.02.2022, p. 2903.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Körnig, C, Staufer, T, Schmutzler, O, Bedke, T, Machicote, A, Liu, B, Liu, Y, Gargioni, E, Feliu, N, Parak, WJ, Huber, S & Grüner, F 2022, 'In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids', SCI REP-UK, vol. 12, no. 1, pp. 2903. https://doi.org/10.1038/s41598-022-06786-4

APA

Körnig, C., Staufer, T., Schmutzler, O., Bedke, T., Machicote, A., Liu, B., Liu, Y., Gargioni, E., Feliu, N., Parak, W. J., Huber, S., & Grüner, F. (2022). In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids. SCI REP-UK, 12(1), 2903. https://doi.org/10.1038/s41598-022-06786-4

Vancouver

Körnig C, Staufer T, Schmutzler O, Bedke T, Machicote A, Liu B et al. In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids. SCI REP-UK. 2022 Feb 21;12(1):2903. https://doi.org/10.1038/s41598-022-06786-4

Bibtex

@article{09dff5e39ac54f7690bb0bc96a452fe1,
title = "In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids",
abstract = "X-ray fluorescence imaging (XFI) is a non-invasive detection method of small quantities of elements, which can be excited to emit fluorescence x-ray photons upon irradiation with an incident x-ray beam. In particular, it can be used to measure nanoparticle uptake in cells and tissue, thus making it a versatile medical imaging modality. However, due to substantially increased multiple Compton scattering background in the measured x-ray spectra, its sensitivity severely decreases for thicker objects, so far limiting its applicability for tracking very small quantities under in-vivo conditions. Reducing the detection limit would enable the ability to track labeled cells, promising new insights into immune response and pharmacokinetics. We present a synchrotron-based approach for reducing the minimal detectable marker concentration by demonstrating the feasibility of XFI for measuring the yet inaccessible distribution of the endogenous iodine in murine thyroids under in-vivo conform conditions. This result can be used as a reference case for the design of future preclinical XFI applications as mentioned above.",
keywords = "Animals, Feasibility Studies, Iodine/metabolism, Limit of Detection, Mice, Inbred C57BL, Spectrometry, X-Ray Emission/methods, Thyroid Gland/diagnostic imaging",
author = "Christian K{\"o}rnig and Theresa Staufer and Oliver Schmutzler and Tanja Bedke and Andres Machicote and Beibei Liu and Yang Liu and Elisabetta Gargioni and Neus Feliu and Parak, {Wolfgang J} and Samuel Huber and Florian Gr{\"u}ner",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = feb,
day = "21",
doi = "10.1038/s41598-022-06786-4",
language = "English",
volume = "12",
pages = "2903",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - In-situ x-ray fluorescence imaging of the endogenous iodine distribution in murine thyroids

AU - Körnig, Christian

AU - Staufer, Theresa

AU - Schmutzler, Oliver

AU - Bedke, Tanja

AU - Machicote, Andres

AU - Liu, Beibei

AU - Liu, Yang

AU - Gargioni, Elisabetta

AU - Feliu, Neus

AU - Parak, Wolfgang J

AU - Huber, Samuel

AU - Grüner, Florian

N1 - © 2022. The Author(s).

PY - 2022/2/21

Y1 - 2022/2/21

N2 - X-ray fluorescence imaging (XFI) is a non-invasive detection method of small quantities of elements, which can be excited to emit fluorescence x-ray photons upon irradiation with an incident x-ray beam. In particular, it can be used to measure nanoparticle uptake in cells and tissue, thus making it a versatile medical imaging modality. However, due to substantially increased multiple Compton scattering background in the measured x-ray spectra, its sensitivity severely decreases for thicker objects, so far limiting its applicability for tracking very small quantities under in-vivo conditions. Reducing the detection limit would enable the ability to track labeled cells, promising new insights into immune response and pharmacokinetics. We present a synchrotron-based approach for reducing the minimal detectable marker concentration by demonstrating the feasibility of XFI for measuring the yet inaccessible distribution of the endogenous iodine in murine thyroids under in-vivo conform conditions. This result can be used as a reference case for the design of future preclinical XFI applications as mentioned above.

AB - X-ray fluorescence imaging (XFI) is a non-invasive detection method of small quantities of elements, which can be excited to emit fluorescence x-ray photons upon irradiation with an incident x-ray beam. In particular, it can be used to measure nanoparticle uptake in cells and tissue, thus making it a versatile medical imaging modality. However, due to substantially increased multiple Compton scattering background in the measured x-ray spectra, its sensitivity severely decreases for thicker objects, so far limiting its applicability for tracking very small quantities under in-vivo conditions. Reducing the detection limit would enable the ability to track labeled cells, promising new insights into immune response and pharmacokinetics. We present a synchrotron-based approach for reducing the minimal detectable marker concentration by demonstrating the feasibility of XFI for measuring the yet inaccessible distribution of the endogenous iodine in murine thyroids under in-vivo conform conditions. This result can be used as a reference case for the design of future preclinical XFI applications as mentioned above.

KW - Animals

KW - Feasibility Studies

KW - Iodine/metabolism

KW - Limit of Detection

KW - Mice, Inbred C57BL

KW - Spectrometry, X-Ray Emission/methods

KW - Thyroid Gland/diagnostic imaging

U2 - 10.1038/s41598-022-06786-4

DO - 10.1038/s41598-022-06786-4

M3 - SCORING: Journal article

C2 - 35190621

VL - 12

SP - 2903

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -