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Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations

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Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations. / Neumann, J; Meissner, A; Bokník, P; Gombosová, I; Knapp, J; Lüss, H; Müller, F U; Schlüter, H; Zidek, W; Rolf, N; Van Aken, H; Vahlensieck, U; Schmitz, W.

In: J CARDIOVASC PHARM, Vol. 33, No. 1, 01.1999, p. 151-6.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Neumann, J, Meissner, A, Bokník, P, Gombosová, I, Knapp, J, Lüss, H, Müller, FU, Schlüter, H, Zidek, W, Rolf, N, Van Aken, H, Vahlensieck, U & Schmitz, W 1999, 'Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations', J CARDIOVASC PHARM, vol. 33, no. 1, pp. 151-6.

APA

Neumann, J., Meissner, A., Bokník, P., Gombosová, I., Knapp, J., Lüss, H., Müller, F. U., Schlüter, H., Zidek, W., Rolf, N., Van Aken, H., Vahlensieck, U., & Schmitz, W. (1999). Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations. J CARDIOVASC PHARM, 33(1), 151-6.

Vancouver

Neumann J, Meissner A, Bokník P, Gombosová I, Knapp J, Lüss H et al. Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations. J CARDIOVASC PHARM. 1999 Jan;33(1):151-6.

Bibtex

@article{f7ccc8f4f3e7467e8759d4cd6ae39c31,
title = "Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations",
abstract = "We studied the effects of diadenosine tetraphosphate (AP4A) on the force of contraction in canine preparations. The force of contraction was measured in isolated electrically driven (1 Hz) atrial and ventricular cardiac trabeculae from adult dogs. AP4A (100 microM) alone and after prestimulation with 10 nM isoproterenol reduced force of contraction in atrial preparations by approximately 24%. Moreover, AP4A (100 microM) alone and after prestimulation with 10 nM isoproterenol reduced the force of contraction in ventricular preparations by 29 and 29%, respectively. The negative inotropic effects of AP4A were abolished by the A1-adenosine receptor antagonist 1,3-dipropyl-cyclopentyl-xanthine (DPCPX). In summary, in canine myocardium, AP4A alone and after prestimulation with a beta-adrenoceptor agonist exerts negative inotropic effects, which are probably mediated via A1-adenosine receptors.",
keywords = "Animals, Atrial Function, Cardiotonic Agents, Dinucleoside Phosphates, Dogs, Heart Ventricles, In Vitro Techniques, Isoproterenol, Myocardial Contraction, Platelet Aggregation Inhibitors, Purinergic P1 Receptor Antagonists, Journal Article, Research Support, Non-U.S. Gov't",
author = "J Neumann and A Meissner and P Bokn{\'i}k and I Gombosov{\'a} and J Knapp and H L{\"u}ss and M{\"u}ller, {F U} and H Schl{\"u}ter and W Zidek and N Rolf and {Van Aken}, H and U Vahlensieck and W Schmitz",
year = "1999",
month = jan,
language = "English",
volume = "33",
pages = "151--6",
journal = "J CARDIOVASC PHARM",
issn = "0160-2446",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Inotropic effects of diadenosine tetraphosphate in isolated canine cardiac preparations

AU - Neumann, J

AU - Meissner, A

AU - Bokník, P

AU - Gombosová, I

AU - Knapp, J

AU - Lüss, H

AU - Müller, F U

AU - Schlüter, H

AU - Zidek, W

AU - Rolf, N

AU - Van Aken, H

AU - Vahlensieck, U

AU - Schmitz, W

PY - 1999/1

Y1 - 1999/1

N2 - We studied the effects of diadenosine tetraphosphate (AP4A) on the force of contraction in canine preparations. The force of contraction was measured in isolated electrically driven (1 Hz) atrial and ventricular cardiac trabeculae from adult dogs. AP4A (100 microM) alone and after prestimulation with 10 nM isoproterenol reduced force of contraction in atrial preparations by approximately 24%. Moreover, AP4A (100 microM) alone and after prestimulation with 10 nM isoproterenol reduced the force of contraction in ventricular preparations by 29 and 29%, respectively. The negative inotropic effects of AP4A were abolished by the A1-adenosine receptor antagonist 1,3-dipropyl-cyclopentyl-xanthine (DPCPX). In summary, in canine myocardium, AP4A alone and after prestimulation with a beta-adrenoceptor agonist exerts negative inotropic effects, which are probably mediated via A1-adenosine receptors.

AB - We studied the effects of diadenosine tetraphosphate (AP4A) on the force of contraction in canine preparations. The force of contraction was measured in isolated electrically driven (1 Hz) atrial and ventricular cardiac trabeculae from adult dogs. AP4A (100 microM) alone and after prestimulation with 10 nM isoproterenol reduced force of contraction in atrial preparations by approximately 24%. Moreover, AP4A (100 microM) alone and after prestimulation with 10 nM isoproterenol reduced the force of contraction in ventricular preparations by 29 and 29%, respectively. The negative inotropic effects of AP4A were abolished by the A1-adenosine receptor antagonist 1,3-dipropyl-cyclopentyl-xanthine (DPCPX). In summary, in canine myocardium, AP4A alone and after prestimulation with a beta-adrenoceptor agonist exerts negative inotropic effects, which are probably mediated via A1-adenosine receptors.

KW - Animals

KW - Atrial Function

KW - Cardiotonic Agents

KW - Dinucleoside Phosphates

KW - Dogs

KW - Heart Ventricles

KW - In Vitro Techniques

KW - Isoproterenol

KW - Myocardial Contraction

KW - Platelet Aggregation Inhibitors

KW - Purinergic P1 Receptor Antagonists

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 9890411

VL - 33

SP - 151

EP - 156

JO - J CARDIOVASC PHARM

JF - J CARDIOVASC PHARM

SN - 0160-2446

IS - 1

ER -