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iNOS promoter variants and severe malaria in Ghanaian children.

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iNOS promoter variants and severe malaria in Ghanaian children. / Cramer, Jakob; Mockenhaupt, Frank P; Ehrhardt, Stephan; Burkhardt, Jana; Otchwemah, Rowland N; Dietz, Ekkehardt; Gellert, Sabine; Bienzle, Ulrich.

In: TROP MED INT HEALTH, Vol. 9, No. 10, 10, 2004, p. 1074-1080.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Cramer, J, Mockenhaupt, FP, Ehrhardt, S, Burkhardt, J, Otchwemah, RN, Dietz, E, Gellert, S & Bienzle, U 2004, 'iNOS promoter variants and severe malaria in Ghanaian children.', TROP MED INT HEALTH, vol. 9, no. 10, 10, pp. 1074-1080. <http://www.ncbi.nlm.nih.gov/pubmed/15482399?dopt=Citation>

APA

Cramer, J., Mockenhaupt, F. P., Ehrhardt, S., Burkhardt, J., Otchwemah, R. N., Dietz, E., Gellert, S., & Bienzle, U. (2004). iNOS promoter variants and severe malaria in Ghanaian children. TROP MED INT HEALTH, 9(10), 1074-1080. [10]. http://www.ncbi.nlm.nih.gov/pubmed/15482399?dopt=Citation

Vancouver

Cramer J, Mockenhaupt FP, Ehrhardt S, Burkhardt J, Otchwemah RN, Dietz E et al. iNOS promoter variants and severe malaria in Ghanaian children. TROP MED INT HEALTH. 2004;9(10):1074-1080. 10.

Bibtex

@article{884782a17c79487cb3f65d1aa91f203a,
title = "iNOS promoter variants and severe malaria in Ghanaian children.",
abstract = "Nitric oxide is an important mediator in the host defence against Plasmodium falciparum malaria. It has antiparasitic effects in vitro. However, its role in clinical disease remains controversial. Polymorphisms in the inducible nitric oxide synthase promoter (iNOS; -954G-->C, -1173C-->T, -2.6 kb CCTTT(n) microsatellite) may influence susceptibility to and severity of malaria. We tested this hypothesis in a case-control study among Ghanaian children with severe malaria (SM) and asymptomatic parasitaemia, respectively, and in healthy controls. In this study, the respective frequencies of iNOS-954G-->C and -1173C-->T did not differ between groups but > or =13 microsatellite copies were associated with SM. -954G-->C and -1173C-->T were in linkage disequilibrium with CCTTT(8) and CCTTT(13), respectively. -954G-->C/CCTTT(8) protected against hyperparasitaemia whereas -1173C-->T/CCTTT(13) increased fatality. These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children.",
author = "Jakob Cramer and Mockenhaupt, {Frank P} and Stephan Ehrhardt and Jana Burkhardt and Otchwemah, {Rowland N} and Ekkehardt Dietz and Sabine Gellert and Ulrich Bienzle",
year = "2004",
language = "Deutsch",
volume = "9",
pages = "1074--1080",
journal = "TROP MED INT HEALTH",
issn = "1360-2276",
publisher = "Wiley-Blackwell",
number = "10",

}

RIS

TY - JOUR

T1 - iNOS promoter variants and severe malaria in Ghanaian children.

AU - Cramer, Jakob

AU - Mockenhaupt, Frank P

AU - Ehrhardt, Stephan

AU - Burkhardt, Jana

AU - Otchwemah, Rowland N

AU - Dietz, Ekkehardt

AU - Gellert, Sabine

AU - Bienzle, Ulrich

PY - 2004

Y1 - 2004

N2 - Nitric oxide is an important mediator in the host defence against Plasmodium falciparum malaria. It has antiparasitic effects in vitro. However, its role in clinical disease remains controversial. Polymorphisms in the inducible nitric oxide synthase promoter (iNOS; -954G-->C, -1173C-->T, -2.6 kb CCTTT(n) microsatellite) may influence susceptibility to and severity of malaria. We tested this hypothesis in a case-control study among Ghanaian children with severe malaria (SM) and asymptomatic parasitaemia, respectively, and in healthy controls. In this study, the respective frequencies of iNOS-954G-->C and -1173C-->T did not differ between groups but > or =13 microsatellite copies were associated with SM. -954G-->C and -1173C-->T were in linkage disequilibrium with CCTTT(8) and CCTTT(13), respectively. -954G-->C/CCTTT(8) protected against hyperparasitaemia whereas -1173C-->T/CCTTT(13) increased fatality. These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children.

AB - Nitric oxide is an important mediator in the host defence against Plasmodium falciparum malaria. It has antiparasitic effects in vitro. However, its role in clinical disease remains controversial. Polymorphisms in the inducible nitric oxide synthase promoter (iNOS; -954G-->C, -1173C-->T, -2.6 kb CCTTT(n) microsatellite) may influence susceptibility to and severity of malaria. We tested this hypothesis in a case-control study among Ghanaian children with severe malaria (SM) and asymptomatic parasitaemia, respectively, and in healthy controls. In this study, the respective frequencies of iNOS-954G-->C and -1173C-->T did not differ between groups but > or =13 microsatellite copies were associated with SM. -954G-->C and -1173C-->T were in linkage disequilibrium with CCTTT(8) and CCTTT(13), respectively. -954G-->C/CCTTT(8) protected against hyperparasitaemia whereas -1173C-->T/CCTTT(13) increased fatality. These findings suggest that iNOS promoter haplotypes rather than single nucleotide polymorphisms are associated with malaria in Ghanaian children.

M3 - SCORING: Zeitschriftenaufsatz

VL - 9

SP - 1074

EP - 1080

JO - TROP MED INT HEALTH

JF - TROP MED INT HEALTH

SN - 1360-2276

IS - 10

M1 - 10

ER -