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Innervation of immune cells: evidence for neuroimmunomodulation in the liver.

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Innervation of immune cells: evidence for neuroimmunomodulation in the liver. / Neuhuber, Winfried L; Tiegs, Gisa.

In: ANAT REC PART A, Vol. 280, No. 1, 1, 2004, p. 884-892.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Neuhuber, WL & Tiegs, G 2004, 'Innervation of immune cells: evidence for neuroimmunomodulation in the liver.', ANAT REC PART A, vol. 280, no. 1, 1, pp. 884-892. <http://www.ncbi.nlm.nih.gov/pubmed/15382013?dopt=Citation>

APA

Neuhuber, W. L., & Tiegs, G. (2004). Innervation of immune cells: evidence for neuroimmunomodulation in the liver. ANAT REC PART A, 280(1), 884-892. [1]. http://www.ncbi.nlm.nih.gov/pubmed/15382013?dopt=Citation

Vancouver

Neuhuber WL, Tiegs G. Innervation of immune cells: evidence for neuroimmunomodulation in the liver. ANAT REC PART A. 2004;280(1):884-892. 1.

Bibtex

@article{d21fe21b93384e5186708819941b1392,
title = "Innervation of immune cells: evidence for neuroimmunomodulation in the liver.",
abstract = "Recent studies have demonstrated a pronounced influence by the autonomic nervous system on immune-mediated experimental hepatitis in the mouse. Adrenergic sympathetic neurons alleviate while capsaicin-sensitive peptidergic primary afferent neurons aggravate liver injury. This was evidenced by recording morphological and functional parameters upon chemical sympathectomy and application of beta-adrenergic agonists, and capsaicin depletion of afferents, neurokinin receptor antagonists, and application of exogenous substance P, respectively. These phenomena are most likely based on close anatomical relationships between nerve fibers and various immune cells in the liver. Modulation of autonomic nervous system functions may open novel therapeutic strategies in immune and inflammatory liver diseases.",
keywords = "Animals, Mice, Adrenergic beta-Agonists/metabolism, Autonomic Nervous System/anatomy & histology/*metabolism, Capsaicin/metabolism, Hepatitis, Animal/*immunology/*metabolism, Kupffer Cells/*cytology/metabolism, Liver/cytology/immunology/*innervation, Lymphocytes/cytology/metabolism, *Models, Immunological, Receptors, Neurotransmitter/agonists, Substance P/metabolism, Animals, Mice, Adrenergic beta-Agonists/metabolism, Autonomic Nervous System/anatomy & histology/*metabolism, Capsaicin/metabolism, Hepatitis, Animal/*immunology/*metabolism, Kupffer Cells/*cytology/metabolism, Liver/cytology/immunology/*innervation, Lymphocytes/cytology/metabolism, *Models, Immunological, Receptors, Neurotransmitter/agonists, Substance P/metabolism",
author = "Neuhuber, {Winfried L} and Gisa Tiegs",
year = "2004",
language = "English",
volume = "280",
pages = "884--892",
number = "1",

}

RIS

TY - JOUR

T1 - Innervation of immune cells: evidence for neuroimmunomodulation in the liver.

AU - Neuhuber, Winfried L

AU - Tiegs, Gisa

PY - 2004

Y1 - 2004

N2 - Recent studies have demonstrated a pronounced influence by the autonomic nervous system on immune-mediated experimental hepatitis in the mouse. Adrenergic sympathetic neurons alleviate while capsaicin-sensitive peptidergic primary afferent neurons aggravate liver injury. This was evidenced by recording morphological and functional parameters upon chemical sympathectomy and application of beta-adrenergic agonists, and capsaicin depletion of afferents, neurokinin receptor antagonists, and application of exogenous substance P, respectively. These phenomena are most likely based on close anatomical relationships between nerve fibers and various immune cells in the liver. Modulation of autonomic nervous system functions may open novel therapeutic strategies in immune and inflammatory liver diseases.

AB - Recent studies have demonstrated a pronounced influence by the autonomic nervous system on immune-mediated experimental hepatitis in the mouse. Adrenergic sympathetic neurons alleviate while capsaicin-sensitive peptidergic primary afferent neurons aggravate liver injury. This was evidenced by recording morphological and functional parameters upon chemical sympathectomy and application of beta-adrenergic agonists, and capsaicin depletion of afferents, neurokinin receptor antagonists, and application of exogenous substance P, respectively. These phenomena are most likely based on close anatomical relationships between nerve fibers and various immune cells in the liver. Modulation of autonomic nervous system functions may open novel therapeutic strategies in immune and inflammatory liver diseases.

KW - Animals

KW - Mice

KW - Adrenergic beta-Agonists/metabolism

KW - Autonomic Nervous System/anatomy & histology/metabolism

KW - Capsaicin/metabolism

KW - Hepatitis, Animal/immunology/metabolism

KW - Kupffer Cells/cytology/metabolism

KW - Liver/cytology/immunology/innervation

KW - Lymphocytes/cytology/metabolism

KW - Models, Immunological

KW - Receptors, Neurotransmitter/agonists

KW - Substance P/metabolism

KW - Animals

KW - Mice

KW - Adrenergic beta-Agonists/metabolism

KW - Autonomic Nervous System/anatomy & histology/metabolism

KW - Capsaicin/metabolism

KW - Hepatitis, Animal/immunology/metabolism

KW - Kupffer Cells/cytology/metabolism

KW - Liver/cytology/immunology/innervation

KW - Lymphocytes/cytology/metabolism

KW - Models, Immunological

KW - Receptors, Neurotransmitter/agonists

KW - Substance P/metabolism

M3 - SCORING: Journal article

VL - 280

SP - 884

EP - 892

IS - 1

M1 - 1

ER -