Innate immune responses to toll-like receptor stimulation are altered during the course of pregnancy
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Innate immune responses to toll-like receptor stimulation are altered during the course of pregnancy. / Ziegler, Susanne Maria; Feldmann, Cai Niklaas; Hagen, Sven Hendrik; Richert, Laura; Barkhausen, Tanja; Goletzke, Janina; Jazbutyte, Virginija; Martrus, Gloria; Salzberger, Wilhelm; Renné, Thomas; Hecher, Kurt; Diemert, Anke; Arck, Petra Clara; Altfeld, Marcus.
In: J REPROD IMMUNOL, Vol. 128, No. SI, 08.2018, p. 30-37.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Innate immune responses to toll-like receptor stimulation are altered during the course of pregnancy
AU - Ziegler, Susanne Maria
AU - Feldmann, Cai Niklaas
AU - Hagen, Sven Hendrik
AU - Richert, Laura
AU - Barkhausen, Tanja
AU - Goletzke, Janina
AU - Jazbutyte, Virginija
AU - Martrus, Gloria
AU - Salzberger, Wilhelm
AU - Renné, Thomas
AU - Hecher, Kurt
AU - Diemert, Anke
AU - Arck, Petra Clara
AU - Altfeld, Marcus
N1 - Copyright © 2018 Elsevier B.V. All rights reserved.
PY - 2018/8
Y1 - 2018/8
N2 - During pregnancy the maternal immune system has to develop tolerance towards the developing fetus. These changes in maternal immunity can result in increased severity of certain infections, but also in amelioration of autoimmune diseases. Pregnancy-related hormones have been suggested to play a central role in the adaptation of the maternal immune system, but their specific effects on innate immune function is not well understood. In a longitudinal study of pregnant women, we investigated innate immune cell function in response to toll-like receptors (TLR) 4 and 7 stimulation, two TLR pathways playing a critical role in early innate immune recognition of bacteria and viruses. IFNα production by TLR7-stimulated pDCs was decreased in early pregnancy, and increased towards the end of pregnancy. In contrast, pro-inflammatory TLR4-induced TNFα production by monocytes was increased during early pregnancy, but declined after the first trimester. Changes in cytokine production were associated with changes in pregnancy-related hormones and monocyte subpopulations over the course of pregnancy. These data demonstrating a significant association between pregnancy-related hormones and modulation of innate immune responses mediated by TLRs provide novel insights into the immunological adaptations occurring during pregnancy.
AB - During pregnancy the maternal immune system has to develop tolerance towards the developing fetus. These changes in maternal immunity can result in increased severity of certain infections, but also in amelioration of autoimmune diseases. Pregnancy-related hormones have been suggested to play a central role in the adaptation of the maternal immune system, but their specific effects on innate immune function is not well understood. In a longitudinal study of pregnant women, we investigated innate immune cell function in response to toll-like receptors (TLR) 4 and 7 stimulation, two TLR pathways playing a critical role in early innate immune recognition of bacteria and viruses. IFNα production by TLR7-stimulated pDCs was decreased in early pregnancy, and increased towards the end of pregnancy. In contrast, pro-inflammatory TLR4-induced TNFα production by monocytes was increased during early pregnancy, but declined after the first trimester. Changes in cytokine production were associated with changes in pregnancy-related hormones and monocyte subpopulations over the course of pregnancy. These data demonstrating a significant association between pregnancy-related hormones and modulation of innate immune responses mediated by TLRs provide novel insights into the immunological adaptations occurring during pregnancy.
KW - Journal Article
U2 - 10.1016/j.jri.2018.05.009
DO - 10.1016/j.jri.2018.05.009
M3 - SCORING: Journal article
C2 - 29886307
VL - 128
SP - 30
EP - 37
JO - J REPROD IMMUNOL
JF - J REPROD IMMUNOL
SN - 0165-0378
IS - SI
ER -
