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Innate immune memory in the brain shapes neurological disease hallmarks

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Innate immune memory in the brain shapes neurological disease hallmarks. / Wendeln, Ann-Christin; Degenhardt, Karoline; Kaurani, Lalit; Gertig, Michael; Ulas, Thomas; Jain, Gaurav; Wagner, Jessica; Häsler, Lisa M; Wild, Katleen; Skodras, Angelos; Blank, Thomas; Staszewski, Ori; Datta, Moumita; Centeno, Tonatiuh Pena; Capece, Vincenzo; Islam, Md Rezaul; Kerimoglu, Cemil; Staufenbiel, Matthias; Schultze, Joachim L; Beyer, Marc; Prinz, Marco; Jucker, Mathias; Fischer, André; Neher, Jonas J.

In: NATURE, Vol. 556, No. 7701, 04.2018, p. 332-338.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Wendeln, A-C, Degenhardt, K, Kaurani, L, Gertig, M, Ulas, T, Jain, G, Wagner, J, Häsler, LM, Wild, K, Skodras, A, Blank, T, Staszewski, O, Datta, M, Centeno, TP, Capece, V, Islam, MR, Kerimoglu, C, Staufenbiel, M, Schultze, JL, Beyer, M, Prinz, M, Jucker, M, Fischer, A & Neher, JJ 2018, 'Innate immune memory in the brain shapes neurological disease hallmarks', NATURE, vol. 556, no. 7701, pp. 332-338. https://doi.org/10.1038/s41586-018-0023-4

APA

Wendeln, A-C., Degenhardt, K., Kaurani, L., Gertig, M., Ulas, T., Jain, G., Wagner, J., Häsler, L. M., Wild, K., Skodras, A., Blank, T., Staszewski, O., Datta, M., Centeno, T. P., Capece, V., Islam, M. R., Kerimoglu, C., Staufenbiel, M., Schultze, J. L., ... Neher, J. J. (2018). Innate immune memory in the brain shapes neurological disease hallmarks. NATURE, 556(7701), 332-338. https://doi.org/10.1038/s41586-018-0023-4

Vancouver

Wendeln A-C, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G et al. Innate immune memory in the brain shapes neurological disease hallmarks. NATURE. 2018 Apr;556(7701):332-338. https://doi.org/10.1038/s41586-018-0023-4

Bibtex

@article{dd53e0d0efae42aaab781e286daeb806,
title = "Innate immune memory in the brain shapes neurological disease hallmarks",
abstract = "Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished-training and tolerance. These are epigenetically mediated and enhance or suppress subsequent inflammation, respectively. Whether immune memory occurs in tissue-resident macrophages in vivo and how it may affect pathology remains largely unknown. Here we demonstrate that peripherally applied inflammatory stimuli induce acute immune training and tolerance in the brain and lead to differential epigenetic reprogramming of brain-resident macrophages (microglia) that persists for at least six months. Strikingly, in a mouse model of Alzheimer's pathology, immune training exacerbates cerebral β-amyloidosis and immune tolerance alleviates it; similarly, peripheral immune stimulation modifies pathological features after stroke. Our results identify immune memory in the brain as an important modifier of neuropathology.",
keywords = "Alzheimer Disease/immunology, Amyloidosis/immunology, Animals, Brain/immunology, Disease Models, Animal, Epigenesis, Genetic, Female, Gene Expression Regulation/immunology, Humans, Immune Tolerance, Immunity, Innate, Immunologic Memory, Inflammation/genetics, Male, Mice, Microglia/immunology, Nervous System Diseases/immunology, Stroke/immunology",
author = "Ann-Christin Wendeln and Karoline Degenhardt and Lalit Kaurani and Michael Gertig and Thomas Ulas and Gaurav Jain and Jessica Wagner and H{\"a}sler, {Lisa M} and Katleen Wild and Angelos Skodras and Thomas Blank and Ori Staszewski and Moumita Datta and Centeno, {Tonatiuh Pena} and Vincenzo Capece and Islam, {Md Rezaul} and Cemil Kerimoglu and Matthias Staufenbiel and Schultze, {Joachim L} and Marc Beyer and Marco Prinz and Mathias Jucker and Andr{\'e} Fischer and Neher, {Jonas J}",
year = "2018",
month = apr,
doi = "10.1038/s41586-018-0023-4",
language = "English",
volume = "556",
pages = "332--338",
journal = "NATURE",
issn = "0028-0836",
publisher = "NATURE PUBLISHING GROUP",
number = "7701",

}

RIS

TY - JOUR

T1 - Innate immune memory in the brain shapes neurological disease hallmarks

AU - Wendeln, Ann-Christin

AU - Degenhardt, Karoline

AU - Kaurani, Lalit

AU - Gertig, Michael

AU - Ulas, Thomas

AU - Jain, Gaurav

AU - Wagner, Jessica

AU - Häsler, Lisa M

AU - Wild, Katleen

AU - Skodras, Angelos

AU - Blank, Thomas

AU - Staszewski, Ori

AU - Datta, Moumita

AU - Centeno, Tonatiuh Pena

AU - Capece, Vincenzo

AU - Islam, Md Rezaul

AU - Kerimoglu, Cemil

AU - Staufenbiel, Matthias

AU - Schultze, Joachim L

AU - Beyer, Marc

AU - Prinz, Marco

AU - Jucker, Mathias

AU - Fischer, André

AU - Neher, Jonas J

PY - 2018/4

Y1 - 2018/4

N2 - Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished-training and tolerance. These are epigenetically mediated and enhance or suppress subsequent inflammation, respectively. Whether immune memory occurs in tissue-resident macrophages in vivo and how it may affect pathology remains largely unknown. Here we demonstrate that peripherally applied inflammatory stimuli induce acute immune training and tolerance in the brain and lead to differential epigenetic reprogramming of brain-resident macrophages (microglia) that persists for at least six months. Strikingly, in a mouse model of Alzheimer's pathology, immune training exacerbates cerebral β-amyloidosis and immune tolerance alleviates it; similarly, peripheral immune stimulation modifies pathological features after stroke. Our results identify immune memory in the brain as an important modifier of neuropathology.

AB - Innate immune memory is a vital mechanism of myeloid cell plasticity that occurs in response to environmental stimuli and alters subsequent immune responses. Two types of immunological imprinting can be distinguished-training and tolerance. These are epigenetically mediated and enhance or suppress subsequent inflammation, respectively. Whether immune memory occurs in tissue-resident macrophages in vivo and how it may affect pathology remains largely unknown. Here we demonstrate that peripherally applied inflammatory stimuli induce acute immune training and tolerance in the brain and lead to differential epigenetic reprogramming of brain-resident macrophages (microglia) that persists for at least six months. Strikingly, in a mouse model of Alzheimer's pathology, immune training exacerbates cerebral β-amyloidosis and immune tolerance alleviates it; similarly, peripheral immune stimulation modifies pathological features after stroke. Our results identify immune memory in the brain as an important modifier of neuropathology.

KW - Alzheimer Disease/immunology

KW - Amyloidosis/immunology

KW - Animals

KW - Brain/immunology

KW - Disease Models, Animal

KW - Epigenesis, Genetic

KW - Female

KW - Gene Expression Regulation/immunology

KW - Humans

KW - Immune Tolerance

KW - Immunity, Innate

KW - Immunologic Memory

KW - Inflammation/genetics

KW - Male

KW - Mice

KW - Microglia/immunology

KW - Nervous System Diseases/immunology

KW - Stroke/immunology

U2 - 10.1038/s41586-018-0023-4

DO - 10.1038/s41586-018-0023-4

M3 - SCORING: Journal article

C2 - 29643512

VL - 556

SP - 332

EP - 338

JO - NATURE

JF - NATURE

SN - 0028-0836

IS - 7701

ER -