Innate immune cells in inflammation and cancer
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Innate immune cells in inflammation and cancer. / Nowarski, Roni; Gagliani, Nicola; Huber, Samuel; Flavell, Richard A.
In: CANCER IMMUNOL RES, Vol. 1, No. 2, 01.08.2013, p. 77-84.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research
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TY - JOUR
T1 - Innate immune cells in inflammation and cancer
AU - Nowarski, Roni
AU - Gagliani, Nicola
AU - Huber, Samuel
AU - Flavell, Richard A
N1 - ©2013 AACR.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflammatory mediators produced in situ by activated innate cells during injury or infection are also associated with increased cancer risk and tumorigenesis. Here, we outline basic principles of innate immune cell functions in inflammation and discuss how these functions converge upon cancer development.
AB - The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflammatory mediators produced in situ by activated innate cells during injury or infection are also associated with increased cancer risk and tumorigenesis. Here, we outline basic principles of innate immune cell functions in inflammation and discuss how these functions converge upon cancer development.
U2 - 10.1158/2326-6066.CIR-13-0081
DO - 10.1158/2326-6066.CIR-13-0081
M3 - SCORING: Journal article
C2 - 24777498
VL - 1
SP - 77
EP - 84
JO - CANCER IMMUNOL RES
JF - CANCER IMMUNOL RES
SN - 2326-6066
IS - 2
ER -