Innate immune cells in inflammation and cancer

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Innate immune cells in inflammation and cancer. / Nowarski, Roni; Gagliani, Nicola; Huber, Samuel; Flavell, Richard A.

In: CANCER IMMUNOL RES, Vol. 1, No. 2, 01.08.2013, p. 77-84.

Research output: SCORING: Contribution to journalSCORING: Journal articleResearch

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@article{da4634c9550a4738a4c458829feb2e61,
title = "Innate immune cells in inflammation and cancer",
abstract = "The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflammatory mediators produced in situ by activated innate cells during injury or infection are also associated with increased cancer risk and tumorigenesis. Here, we outline basic principles of innate immune cell functions in inflammation and discuss how these functions converge upon cancer development.",
author = "Roni Nowarski and Nicola Gagliani and Samuel Huber and Flavell, {Richard A}",
note = "{\textcopyright}2013 AACR.",
year = "2013",
month = aug,
day = "1",
doi = "10.1158/2326-6066.CIR-13-0081",
language = "English",
volume = "1",
pages = "77--84",
journal = "CANCER IMMUNOL RES",
issn = "2326-6066",
publisher = "American Association for Cancer Research Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Innate immune cells in inflammation and cancer

AU - Nowarski, Roni

AU - Gagliani, Nicola

AU - Huber, Samuel

AU - Flavell, Richard A

N1 - ©2013 AACR.

PY - 2013/8/1

Y1 - 2013/8/1

N2 - The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflammatory mediators produced in situ by activated innate cells during injury or infection are also associated with increased cancer risk and tumorigenesis. Here, we outline basic principles of innate immune cell functions in inflammation and discuss how these functions converge upon cancer development.

AB - The innate immune system has evolved in multicellular organisms to detect and respond to situations that compromise tissue homeostasis. It comprises a set of tissue-resident and circulating leukocytes primarily designed to sense pathogens and tissue damage through hardwired receptors and eliminate noxious sources by mediating inflammatory processes. While indispensable to immunity, the inflammatory mediators produced in situ by activated innate cells during injury or infection are also associated with increased cancer risk and tumorigenesis. Here, we outline basic principles of innate immune cell functions in inflammation and discuss how these functions converge upon cancer development.

U2 - 10.1158/2326-6066.CIR-13-0081

DO - 10.1158/2326-6066.CIR-13-0081

M3 - SCORING: Journal article

C2 - 24777498

VL - 1

SP - 77

EP - 84

JO - CANCER IMMUNOL RES

JF - CANCER IMMUNOL RES

SN - 2326-6066

IS - 2

ER -