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In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery

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In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery. / Cano Garcia, Cristina; Tappero, Stefano; Piccinelli, Mattia Luca; Barletta, Francesco; Incesu, Reha-Baris; Morra, Simone; Scheipner, Lukas; Baudo, Andrea; Tian, Zhe; Hoeh, Benedikt; Chierigo, Francesco; Sorce, Gabriele; Saad, Fred; Shariat, Shahrokh F; Carmignani, Luca; Ahyai, Sascha; Longo, Nicola; Tilki, Derya; Briganti, Alberto; De Cobell, Ottavio; Dell'Oglio, Paolo; Mandel, Philipp; Terrone, Carlo; Chun, Felix K H; Karakiewicz, Pierre I.

In: ANN SURG ONCOL, Vol. 30, No. 13, 12.2023, p. 8770-8779.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Cano Garcia, C, Tappero, S, Piccinelli, ML, Barletta, F, Incesu, R-B, Morra, S, Scheipner, L, Baudo, A, Tian, Z, Hoeh, B, Chierigo, F, Sorce, G, Saad, F, Shariat, SF, Carmignani, L, Ahyai, S, Longo, N, Tilki, D, Briganti, A, De Cobell, O, Dell'Oglio, P, Mandel, P, Terrone, C, Chun, FKH & Karakiewicz, PI 2023, 'In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery', ANN SURG ONCOL, vol. 30, no. 13, pp. 8770-8779. https://doi.org/10.1245/s10434-023-14246-0

APA

Cano Garcia, C., Tappero, S., Piccinelli, M. L., Barletta, F., Incesu, R-B., Morra, S., Scheipner, L., Baudo, A., Tian, Z., Hoeh, B., Chierigo, F., Sorce, G., Saad, F., Shariat, S. F., Carmignani, L., Ahyai, S., Longo, N., Tilki, D., Briganti, A., ... Karakiewicz, P. I. (2023). In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery. ANN SURG ONCOL, 30(13), 8770-8779. https://doi.org/10.1245/s10434-023-14246-0

Vancouver

Cano Garcia C, Tappero S, Piccinelli ML, Barletta F, Incesu R-B, Morra S et al. In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery. ANN SURG ONCOL. 2023 Dec;30(13):8770-8779. https://doi.org/10.1245/s10434-023-14246-0

Bibtex

@article{676d31e141184ddbb0e8d0c5465b4d1e,
title = "In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery",
abstract = "BACKGROUND: This study aimed to test for temporal trends of in-hospital venous thromboembolism (VTE) and pulmonary embolism (PE) after major urologic cancer surgery (MUCS).METHODS: In the Nationwide Inpatient Sample (NIS) database (2010-2019), this study identified non-metastatic radical cystectomy (RC), radical prostatectomy (RP), radical nephrectomy (RN), and partial nephrectomy (PN) patients. Temporal trends of VTE and PE and multivariable logistic regression analyses (MLR) addressing VTE or PE, and mortality with VTE or PE were performed.RESULTS: Of 196,915 patients, 1180 (1.0%) exhibited VTE and 583 (0.3%) exhibited PE. The VTE rates increased from 0.6 to 0.7% (estimated annual percentage change [EAPC] + 4.0%; p = 0.01). Conversely, the PE rates decreased from 0.4 to 0.2% (EAPC - 4.5%; p = 0.01). No difference was observed in mortality with VTE (EAPC - 2.1%; p = 0.7) or with PE (EAPC - 1.2%; p = 0.8). In MLR relative to RP, RC (odds ratio [OR] 5.1), RN (OR 4.5), and PN (OR 3.6) were associated with higher VTE risk (all p < 0.001). Similarly in MLR relative to RP, RC (OR 4.6), RN (OR 3.3), and PN (OR 3.9) were associated with higher PE risk (all p < 0.001). In MLR, the risk of mortality was higher when VTE or PE was present in RC (VTE: OR 3.7, PE: OR 4.8; both p < 0.001) and RN (VTE: OR 5.2, PE: OR 8.3; both p < 0.001).CONCLUSIONS: RC, RN, and PN predisposes to a higher VTE and PE rates than RP. Moreover, among RC and RN patients with either VTE or PE, mortality is substantially higher than among their VTE or PE-free counterparts.",
keywords = "Male, Humans, Venous Thromboembolism, Urologic Neoplasms/surgery, Nephrectomy, Pulmonary Embolism, Hospitals, Risk Factors",
author = "{Cano Garcia}, Cristina and Stefano Tappero and Piccinelli, {Mattia Luca} and Francesco Barletta and Reha-Baris Incesu and Simone Morra and Lukas Scheipner and Andrea Baudo and Zhe Tian and Benedikt Hoeh and Francesco Chierigo and Gabriele Sorce and Fred Saad and Shariat, {Shahrokh F} and Luca Carmignani and Sascha Ahyai and Nicola Longo and Derya Tilki and Alberto Briganti and {De Cobell}, Ottavio and Paolo Dell'Oglio and Philipp Mandel and Carlo Terrone and Chun, {Felix K H} and Karakiewicz, {Pierre I}",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
month = dec,
doi = "10.1245/s10434-023-14246-0",
language = "English",
volume = "30",
pages = "8770--8779",
journal = "ANN SURG ONCOL",
issn = "1068-9265",
publisher = "Springer New York",
number = "13",

}

RIS

TY - JOUR

T1 - In-Hospital Venous Thromboembolism and Pulmonary Embolism After Major Urologic Cancer Surgery

AU - Cano Garcia, Cristina

AU - Tappero, Stefano

AU - Piccinelli, Mattia Luca

AU - Barletta, Francesco

AU - Incesu, Reha-Baris

AU - Morra, Simone

AU - Scheipner, Lukas

AU - Baudo, Andrea

AU - Tian, Zhe

AU - Hoeh, Benedikt

AU - Chierigo, Francesco

AU - Sorce, Gabriele

AU - Saad, Fred

AU - Shariat, Shahrokh F

AU - Carmignani, Luca

AU - Ahyai, Sascha

AU - Longo, Nicola

AU - Tilki, Derya

AU - Briganti, Alberto

AU - De Cobell, Ottavio

AU - Dell'Oglio, Paolo

AU - Mandel, Philipp

AU - Terrone, Carlo

AU - Chun, Felix K H

AU - Karakiewicz, Pierre I

N1 - © 2023. The Author(s).

PY - 2023/12

Y1 - 2023/12

N2 - BACKGROUND: This study aimed to test for temporal trends of in-hospital venous thromboembolism (VTE) and pulmonary embolism (PE) after major urologic cancer surgery (MUCS).METHODS: In the Nationwide Inpatient Sample (NIS) database (2010-2019), this study identified non-metastatic radical cystectomy (RC), radical prostatectomy (RP), radical nephrectomy (RN), and partial nephrectomy (PN) patients. Temporal trends of VTE and PE and multivariable logistic regression analyses (MLR) addressing VTE or PE, and mortality with VTE or PE were performed.RESULTS: Of 196,915 patients, 1180 (1.0%) exhibited VTE and 583 (0.3%) exhibited PE. The VTE rates increased from 0.6 to 0.7% (estimated annual percentage change [EAPC] + 4.0%; p = 0.01). Conversely, the PE rates decreased from 0.4 to 0.2% (EAPC - 4.5%; p = 0.01). No difference was observed in mortality with VTE (EAPC - 2.1%; p = 0.7) or with PE (EAPC - 1.2%; p = 0.8). In MLR relative to RP, RC (odds ratio [OR] 5.1), RN (OR 4.5), and PN (OR 3.6) were associated with higher VTE risk (all p < 0.001). Similarly in MLR relative to RP, RC (OR 4.6), RN (OR 3.3), and PN (OR 3.9) were associated with higher PE risk (all p < 0.001). In MLR, the risk of mortality was higher when VTE or PE was present in RC (VTE: OR 3.7, PE: OR 4.8; both p < 0.001) and RN (VTE: OR 5.2, PE: OR 8.3; both p < 0.001).CONCLUSIONS: RC, RN, and PN predisposes to a higher VTE and PE rates than RP. Moreover, among RC and RN patients with either VTE or PE, mortality is substantially higher than among their VTE or PE-free counterparts.

AB - BACKGROUND: This study aimed to test for temporal trends of in-hospital venous thromboembolism (VTE) and pulmonary embolism (PE) after major urologic cancer surgery (MUCS).METHODS: In the Nationwide Inpatient Sample (NIS) database (2010-2019), this study identified non-metastatic radical cystectomy (RC), radical prostatectomy (RP), radical nephrectomy (RN), and partial nephrectomy (PN) patients. Temporal trends of VTE and PE and multivariable logistic regression analyses (MLR) addressing VTE or PE, and mortality with VTE or PE were performed.RESULTS: Of 196,915 patients, 1180 (1.0%) exhibited VTE and 583 (0.3%) exhibited PE. The VTE rates increased from 0.6 to 0.7% (estimated annual percentage change [EAPC] + 4.0%; p = 0.01). Conversely, the PE rates decreased from 0.4 to 0.2% (EAPC - 4.5%; p = 0.01). No difference was observed in mortality with VTE (EAPC - 2.1%; p = 0.7) or with PE (EAPC - 1.2%; p = 0.8). In MLR relative to RP, RC (odds ratio [OR] 5.1), RN (OR 4.5), and PN (OR 3.6) were associated with higher VTE risk (all p < 0.001). Similarly in MLR relative to RP, RC (OR 4.6), RN (OR 3.3), and PN (OR 3.9) were associated with higher PE risk (all p < 0.001). In MLR, the risk of mortality was higher when VTE or PE was present in RC (VTE: OR 3.7, PE: OR 4.8; both p < 0.001) and RN (VTE: OR 5.2, PE: OR 8.3; both p < 0.001).CONCLUSIONS: RC, RN, and PN predisposes to a higher VTE and PE rates than RP. Moreover, among RC and RN patients with either VTE or PE, mortality is substantially higher than among their VTE or PE-free counterparts.

KW - Male

KW - Humans

KW - Venous Thromboembolism

KW - Urologic Neoplasms/surgery

KW - Nephrectomy

KW - Pulmonary Embolism

KW - Hospitals

KW - Risk Factors

U2 - 10.1245/s10434-023-14246-0

DO - 10.1245/s10434-023-14246-0

M3 - SCORING: Journal article

C2 - 37721691

VL - 30

SP - 8770

EP - 8779

JO - ANN SURG ONCOL

JF - ANN SURG ONCOL

SN - 1068-9265

IS - 13

ER -