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Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice.

Standard

Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. / Sass, Gabriele; Leukel, Petra; Schmitz, Volker; Raskopf, Esther; Ocker, Matthias; Neureiter, Daniel; Meissnitzer, Matthias; Tasika, Elena; Tannapfel, Andrea; Tiegs, Gisa.

In: INT J CANCER, Vol. 123, No. 6, 6, 2008, p. 1269-1277.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sass, G, Leukel, P, Schmitz, V, Raskopf, E, Ocker, M, Neureiter, D, Meissnitzer, M, Tasika, E, Tannapfel, A & Tiegs, G 2008, 'Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice.', INT J CANCER, vol. 123, no. 6, 6, pp. 1269-1277. <http://www.ncbi.nlm.nih.gov/pubmed/18566988?dopt=Citation>

APA

Sass, G., Leukel, P., Schmitz, V., Raskopf, E., Ocker, M., Neureiter, D., Meissnitzer, M., Tasika, E., Tannapfel, A., & Tiegs, G. (2008). Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. INT J CANCER, 123(6), 1269-1277. [6]. http://www.ncbi.nlm.nih.gov/pubmed/18566988?dopt=Citation

Vancouver

Sass G, Leukel P, Schmitz V, Raskopf E, Ocker M, Neureiter D et al. Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice. INT J CANCER. 2008;123(6):1269-1277. 6.

Bibtex

@article{feaa87c880dd45898449a8f96077b388,
title = "Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice.",
abstract = "Endogenous overexpression of the antiapoptotic protein heme oxygenase 1 (HO-1) has been shown to occur in various cancer diseases and might contribute to cancer progression. We compared the expression levels of HO-1 in human liver to expression levels in hepatocellular carcinoma (HCC), as well as the effect of HO-1 inhibition by small interfering RNA (siRNA) on cellular survival and apoptosis in the mouse hepatoma cell lines Hepa129 and Hepa1-6 and on orthotopic tumor growth in immune-competent C3H/HeN mice. Our results show that HO-1 is frequently overexpressed in human HCC. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic HCC and reduced angiogenesis. Livers and kidneys of treated animals did not reveal signs of damage by this treatment. In conclusion, a specific knockdown of HO-1 might represent a novel therapeutic approach in HCC therapy.",
author = "Gabriele Sass and Petra Leukel and Volker Schmitz and Esther Raskopf and Matthias Ocker and Daniel Neureiter and Matthias Meissnitzer and Elena Tasika and Andrea Tannapfel and Gisa Tiegs",
year = "2008",
language = "Deutsch",
volume = "123",
pages = "1269--1277",
journal = "INT J CANCER",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Inhibition of heme oxygenase 1 expression by small interfering RNA decreases orthotopic tumor growth in livers of mice.

AU - Sass, Gabriele

AU - Leukel, Petra

AU - Schmitz, Volker

AU - Raskopf, Esther

AU - Ocker, Matthias

AU - Neureiter, Daniel

AU - Meissnitzer, Matthias

AU - Tasika, Elena

AU - Tannapfel, Andrea

AU - Tiegs, Gisa

PY - 2008

Y1 - 2008

N2 - Endogenous overexpression of the antiapoptotic protein heme oxygenase 1 (HO-1) has been shown to occur in various cancer diseases and might contribute to cancer progression. We compared the expression levels of HO-1 in human liver to expression levels in hepatocellular carcinoma (HCC), as well as the effect of HO-1 inhibition by small interfering RNA (siRNA) on cellular survival and apoptosis in the mouse hepatoma cell lines Hepa129 and Hepa1-6 and on orthotopic tumor growth in immune-competent C3H/HeN mice. Our results show that HO-1 is frequently overexpressed in human HCC. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic HCC and reduced angiogenesis. Livers and kidneys of treated animals did not reveal signs of damage by this treatment. In conclusion, a specific knockdown of HO-1 might represent a novel therapeutic approach in HCC therapy.

AB - Endogenous overexpression of the antiapoptotic protein heme oxygenase 1 (HO-1) has been shown to occur in various cancer diseases and might contribute to cancer progression. We compared the expression levels of HO-1 in human liver to expression levels in hepatocellular carcinoma (HCC), as well as the effect of HO-1 inhibition by small interfering RNA (siRNA) on cellular survival and apoptosis in the mouse hepatoma cell lines Hepa129 and Hepa1-6 and on orthotopic tumor growth in immune-competent C3H/HeN mice. Our results show that HO-1 is frequently overexpressed in human HCC. Downmodulation of HO-1 by siRNA resulted in increased cellular damage and apoptosis, reduced proliferation, reduced growth of orthotopic HCC and reduced angiogenesis. Livers and kidneys of treated animals did not reveal signs of damage by this treatment. In conclusion, a specific knockdown of HO-1 might represent a novel therapeutic approach in HCC therapy.

M3 - SCORING: Zeitschriftenaufsatz

VL - 123

SP - 1269

EP - 1277

JO - INT J CANCER

JF - INT J CANCER

SN - 0020-7136

IS - 6

M1 - 6

ER -