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Inhibition of dendritic cell generation and function by serum from prostate cancer patients: correlation with serum-free PSA.

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Inhibition of dendritic cell generation and function by serum from prostate cancer patients: correlation with serum-free PSA. / Aalamian-Matheis, Maryam; Chatta, Gurkamal S; Shurin, Michael R; Huland, Edith; Huland, Hartwig; Shurin, Galina V.

In: ADV EXP MED BIOL, Vol. 601, 2007, p. 173-182.

Research output: SCORING: Contribution to journal › Conference article in journal › Research › peer-review

Harvard

Aalamian-Matheis, M, Chatta, GS, Shurin, MR, Huland, E, Huland, H & Shurin, GV 2007, 'Inhibition of dendritic cell generation and function by serum from prostate cancer patients: correlation with serum-free PSA.', ADV EXP MED BIOL, vol. 601, pp. 173-182. https://doi.org/10.1007/978-0-387-72005-0_18

APA

Aalamian-Matheis, M., Chatta, G. S., Shurin, M. R., Huland, E., Huland, H., & Shurin, G. V. (2007). Inhibition of dendritic cell generation and function by serum from prostate cancer patients: correlation with serum-free PSA. ADV EXP MED BIOL, 601, 173-182. https://doi.org/10.1007/978-0-387-72005-0_18

Vancouver

Aalamian-Matheis M, Chatta GS, Shurin MR, Huland E, Huland H, Shurin GV. Inhibition of dendritic cell generation and function by serum from prostate cancer patients: correlation with serum-free PSA. ADV EXP MED BIOL. 2007;601:173-182. https://doi.org/10.1007/978-0-387-72005-0_18

Bibtex

@article{0935fca89a1747709f6971f43f7429f0,
title = "Inhibition of dendritic cell generation and function by serum from prostate cancer patients: correlation with serum-free PSA.",
abstract = "Tumor produces a number of immunosuppressive factors that block maturation of dendritic cells (DCs). Here, we demonstrated that endogenous factors presented in the serum of patients with prostate cancer (CaP) inhibited the generation of functionally active DCs from CD14+ monocytes in vitro. We have shown a significant inhibitory potential of serum obtained from patients with CaP and benign prostate hyperplasia benign prostatic hyperplasia (BPH) when compared with serum from healthy volunteers. As assessed by flow cytometry, expression of CD83, CD86, and CD40 molecules was strongly inhibited by CaP and BPH serum. In addition, these DCs were weak stimulators of allogeneic T cell proliferation when compared with DCs produced in the presence of healthy volunteer serum. Statistical analysis of the results revealed a positive relationship between the inhibition of expression of DC markers CD83 and CD80 and the levels of serum-free prostate-specific antigen (PSA). These data suggest that the DC system may be impaired in CaP patients.",
author = "Maryam Aalamian-Matheis and Chatta, {Gurkamal S} and Shurin, {Michael R} and Edith Huland and Hartwig Huland and Shurin, {Galina V}",
year = "2007",
doi = "10.1007/978-0-387-72005-0_18",
language = "Deutsch",
volume = "601",
pages = "173--182",
journal = "ADV EXP MED BIOL",
issn = "0065-2598",
publisher = "Springer New York",

}

RIS

TY - JOUR

T1 - Inhibition of dendritic cell generation and function by serum from prostate cancer patients: correlation with serum-free PSA.

AU - Aalamian-Matheis, Maryam

AU - Chatta, Gurkamal S

AU - Shurin, Michael R

AU - Huland, Edith

AU - Huland, Hartwig

AU - Shurin, Galina V

PY - 2007

Y1 - 2007

N2 - Tumor produces a number of immunosuppressive factors that block maturation of dendritic cells (DCs). Here, we demonstrated that endogenous factors presented in the serum of patients with prostate cancer (CaP) inhibited the generation of functionally active DCs from CD14+ monocytes in vitro. We have shown a significant inhibitory potential of serum obtained from patients with CaP and benign prostate hyperplasia benign prostatic hyperplasia (BPH) when compared with serum from healthy volunteers. As assessed by flow cytometry, expression of CD83, CD86, and CD40 molecules was strongly inhibited by CaP and BPH serum. In addition, these DCs were weak stimulators of allogeneic T cell proliferation when compared with DCs produced in the presence of healthy volunteer serum. Statistical analysis of the results revealed a positive relationship between the inhibition of expression of DC markers CD83 and CD80 and the levels of serum-free prostate-specific antigen (PSA). These data suggest that the DC system may be impaired in CaP patients.

AB - Tumor produces a number of immunosuppressive factors that block maturation of dendritic cells (DCs). Here, we demonstrated that endogenous factors presented in the serum of patients with prostate cancer (CaP) inhibited the generation of functionally active DCs from CD14+ monocytes in vitro. We have shown a significant inhibitory potential of serum obtained from patients with CaP and benign prostate hyperplasia benign prostatic hyperplasia (BPH) when compared with serum from healthy volunteers. As assessed by flow cytometry, expression of CD83, CD86, and CD40 molecules was strongly inhibited by CaP and BPH serum. In addition, these DCs were weak stimulators of allogeneic T cell proliferation when compared with DCs produced in the presence of healthy volunteer serum. Statistical analysis of the results revealed a positive relationship between the inhibition of expression of DC markers CD83 and CD80 and the levels of serum-free prostate-specific antigen (PSA). These data suggest that the DC system may be impaired in CaP patients.

U2 - 10.1007/978-0-387-72005-0_18

DO - 10.1007/978-0-387-72005-0_18

M3 - Konferenzaufsatz in Fachzeitschrift

VL - 601

SP - 173

EP - 182

JO - ADV EXP MED BIOL

JF - ADV EXP MED BIOL

SN - 0065-2598

ER -