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Influence of sex and age on morphological organ damage after hemorrhagic shock

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Influence of sex and age on morphological organ damage after hemorrhagic shock. / Mees, Soeren Torge; Gwinner, Maike; Marx, Kerstin; Faendrich, Fred; Schroeder, Joerg; Haier, Joerg; Kahlke, Volker.

In: SHOCK, Vol. 29, No. 6, 06.2008, p. 670-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Mees, ST, Gwinner, M, Marx, K, Faendrich, F, Schroeder, J, Haier, J & Kahlke, V 2008, 'Influence of sex and age on morphological organ damage after hemorrhagic shock', SHOCK, vol. 29, no. 6, pp. 670-4. https://doi.org/10.1097/shk.0b013e31815c3ea0

APA

Mees, S. T., Gwinner, M., Marx, K., Faendrich, F., Schroeder, J., Haier, J., & Kahlke, V. (2008). Influence of sex and age on morphological organ damage after hemorrhagic shock. SHOCK, 29(6), 670-4. https://doi.org/10.1097/shk.0b013e31815c3ea0

Vancouver

Mees ST, Gwinner M, Marx K, Faendrich F, Schroeder J, Haier J et al. Influence of sex and age on morphological organ damage after hemorrhagic shock. SHOCK. 2008 Jun;29(6):670-4. https://doi.org/10.1097/shk.0b013e31815c3ea0

Bibtex

@article{1be9e0367cf8417f80dcbcfc0a87f084,
title = "Influence of sex and age on morphological organ damage after hemorrhagic shock",
abstract = "Immune function after hemorrhagic shock (shock) and subsequent sepsis is proofed to be sex- and age-related, showing an enhanced immune function and better survival of young females and a deteriorating immune response in advanced age. However, it remains unclear if the observed sex- and age-related effects observed on the immune function mirror the histomorphological changes of the affected organs. To scrutinize a possible association, male and female CBA/J mice (young, 2-3 months; aged 18-19 months) were subjected to shock (35 + 5 mmHg for 90 min and fluid resuscitation) or sham operation. At 48 h after shock, histological specimen at definite sites were harvested (lung, small bowel, liver, and kidney) and immediately stored in 10% formalin. After paraffin embedding, hematoxylin-eosin stain and immunohistochemical stains (vascular cell adhesion molecule 1 [VCAM-1], cluster of differentiation 44 [CD44], signal transducers and activators of transcription 3 [STAT-3]) were performed. In both sexes, aged animals developed significantly increased (P < 0.05) tissue damage in all analyzed organs compared with young mice. Sex differences were noticed in the lungs of young mice, showing a significantly (P < 0.05) lower organ damage score in female animals. Sex-related differences were found for VCAM-1 and cluster of differentiation 44 expression, whereas age-related changes were observed for STAT-3. These results demonstrate that the severity of tissue damage caused by hemorrhagic shock is influenced by sex- and age-related effects. Variances in the VCAM-1 and STAT-3 expression suggest that improved immune function in female and young subjects may be responsible for less shock-induced tissue damage.",
keywords = "Age Factors, Aging, Animals, Antigens, CD44, Female, Male, Mice, STAT3 Transcription Factor, Sex Characteristics, Sex Factors, Shock, Hemorrhagic, Time Factors, Vascular Cell Adhesion Molecule-1",
author = "Mees, {Soeren Torge} and Maike Gwinner and Kerstin Marx and Fred Faendrich and Joerg Schroeder and Joerg Haier and Volker Kahlke",
year = "2008",
month = jun,
doi = "10.1097/shk.0b013e31815c3ea0",
language = "English",
volume = "29",
pages = "670--4",
journal = "SHOCK",
issn = "1073-2322",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

RIS

TY - JOUR

T1 - Influence of sex and age on morphological organ damage after hemorrhagic shock

AU - Mees, Soeren Torge

AU - Gwinner, Maike

AU - Marx, Kerstin

AU - Faendrich, Fred

AU - Schroeder, Joerg

AU - Haier, Joerg

AU - Kahlke, Volker

PY - 2008/6

Y1 - 2008/6

N2 - Immune function after hemorrhagic shock (shock) and subsequent sepsis is proofed to be sex- and age-related, showing an enhanced immune function and better survival of young females and a deteriorating immune response in advanced age. However, it remains unclear if the observed sex- and age-related effects observed on the immune function mirror the histomorphological changes of the affected organs. To scrutinize a possible association, male and female CBA/J mice (young, 2-3 months; aged 18-19 months) were subjected to shock (35 + 5 mmHg for 90 min and fluid resuscitation) or sham operation. At 48 h after shock, histological specimen at definite sites were harvested (lung, small bowel, liver, and kidney) and immediately stored in 10% formalin. After paraffin embedding, hematoxylin-eosin stain and immunohistochemical stains (vascular cell adhesion molecule 1 [VCAM-1], cluster of differentiation 44 [CD44], signal transducers and activators of transcription 3 [STAT-3]) were performed. In both sexes, aged animals developed significantly increased (P < 0.05) tissue damage in all analyzed organs compared with young mice. Sex differences were noticed in the lungs of young mice, showing a significantly (P < 0.05) lower organ damage score in female animals. Sex-related differences were found for VCAM-1 and cluster of differentiation 44 expression, whereas age-related changes were observed for STAT-3. These results demonstrate that the severity of tissue damage caused by hemorrhagic shock is influenced by sex- and age-related effects. Variances in the VCAM-1 and STAT-3 expression suggest that improved immune function in female and young subjects may be responsible for less shock-induced tissue damage.

AB - Immune function after hemorrhagic shock (shock) and subsequent sepsis is proofed to be sex- and age-related, showing an enhanced immune function and better survival of young females and a deteriorating immune response in advanced age. However, it remains unclear if the observed sex- and age-related effects observed on the immune function mirror the histomorphological changes of the affected organs. To scrutinize a possible association, male and female CBA/J mice (young, 2-3 months; aged 18-19 months) were subjected to shock (35 + 5 mmHg for 90 min and fluid resuscitation) or sham operation. At 48 h after shock, histological specimen at definite sites were harvested (lung, small bowel, liver, and kidney) and immediately stored in 10% formalin. After paraffin embedding, hematoxylin-eosin stain and immunohistochemical stains (vascular cell adhesion molecule 1 [VCAM-1], cluster of differentiation 44 [CD44], signal transducers and activators of transcription 3 [STAT-3]) were performed. In both sexes, aged animals developed significantly increased (P < 0.05) tissue damage in all analyzed organs compared with young mice. Sex differences were noticed in the lungs of young mice, showing a significantly (P < 0.05) lower organ damage score in female animals. Sex-related differences were found for VCAM-1 and cluster of differentiation 44 expression, whereas age-related changes were observed for STAT-3. These results demonstrate that the severity of tissue damage caused by hemorrhagic shock is influenced by sex- and age-related effects. Variances in the VCAM-1 and STAT-3 expression suggest that improved immune function in female and young subjects may be responsible for less shock-induced tissue damage.

KW - Age Factors

KW - Aging

KW - Animals

KW - Antigens, CD44

KW - Female

KW - Male

KW - Mice

KW - STAT3 Transcription Factor

KW - Sex Characteristics

KW - Sex Factors

KW - Shock, Hemorrhagic

KW - Time Factors

KW - Vascular Cell Adhesion Molecule-1

U2 - 10.1097/shk.0b013e31815c3ea0

DO - 10.1097/shk.0b013e31815c3ea0

M3 - SCORING: Journal article

C2 - 17998889

VL - 29

SP - 670

EP - 674

JO - SHOCK

JF - SHOCK

SN - 1073-2322

IS - 6

ER -