Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors.

O W Neth; U Bacher; P Das; T Zabelina; H Kabisch; N Kroeger; Francis Ayuk Ayuketang; M Lioznov; O Waschke; B Fehse; R Thiébaut; R M Haston; N Klein; A R Zander

doi:10.1038/bmt.2009.90

Influence of mannose-binding lectin genotypes and serostatus in allo-SCT: analysis of 131 recipients and donors.

O W Neth
U Bacher
P Das
T Zabelina
H Kabisch
N Kroeger
Francis Ayuk Ayuketang
M Lioznov
O Waschke
B Fehse
R Thiébaut
R M Haston
N Klein
A R Zander

Related Research units

Department of Stem Cell Transplantation

Abstract

Mannan-binding lectin (MBL) deficiency is determined by MBL gene polymorphisms and is associated with an increased infection risk. To clarify the role of MBL in Allo-SCT, 131 recipients-donors were analysed. MBL genotypes were determined by PCR and heteroduplex analyses, MBL serum levels by ELISA, and MBL oligomers by western blotting. MBL levels

Bibliographical data

Original language	English
ISSN	0268-3369
DOIs	https://doi.org/10.1038/bmt.2009.90
Publication status	Published - 01.01.2010