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Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium

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Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium. / Oskarsson, Viktor; Eliasson, Mats; Salomaa, Veikko; Reinikainen, Jaakko; Männistö, Satu; Palmieri, Luigi; Donfrancesco, Chiara; Sans, Susana; Costanzo, Simona; de Gaetano, Giovanni; Iacoviello, Licia; Veronesi, Giovanni; Ferrario, Marco M; Padro, Teresa; Thorand, Barbara; Huth, Cornelia; Zeller, Tanja; Blankenberg, Stefan; Anderson, Annie S; Tunstall-Pedoe, Hugh; Kuulasmaa, Kari; Söderberg, Stefan; BiomarCaRE Investigators.

In: BRIT J NUTR, Vol. 128, No. 11, 14.12.2022, p. 2208-2218.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Oskarsson, V, Eliasson, M, Salomaa, V, Reinikainen, J, Männistö, S, Palmieri, L, Donfrancesco, C, Sans, S, Costanzo, S, de Gaetano, G, Iacoviello, L, Veronesi, G, Ferrario, MM, Padro, T, Thorand, B, Huth, C, Zeller, T, Blankenberg, S, Anderson, AS, Tunstall-Pedoe, H, Kuulasmaa, K, Söderberg, S & BiomarCaRE Investigators 2022, 'Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium', BRIT J NUTR, vol. 128, no. 11, pp. 2208-2218. https://doi.org/10.1017/S0007114521005080

APA

Oskarsson, V., Eliasson, M., Salomaa, V., Reinikainen, J., Männistö, S., Palmieri, L., Donfrancesco, C., Sans, S., Costanzo, S., de Gaetano, G., Iacoviello, L., Veronesi, G., Ferrario, M. M., Padro, T., Thorand, B., Huth, C., Zeller, T., Blankenberg, S., Anderson, A. S., ... BiomarCaRE Investigators (2022). Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium. BRIT J NUTR, 128(11), 2208-2218. https://doi.org/10.1017/S0007114521005080

Vancouver

Oskarsson V, Eliasson M, Salomaa V, Reinikainen J, Männistö S, Palmieri L et al. Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium. BRIT J NUTR. 2022 Dec 14;128(11):2208-2218. https://doi.org/10.1017/S0007114521005080

Bibtex

@article{a682f2fb4cb646d0a5739b3a73d861eb,
title = "Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium",
abstract = "Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in six European countries using harmonised immunoassay data from 81 084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48·9 %; median age 50·8 years; examination period 1984-2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65·6-63·8°N), Germany (at 48·4°N), Finland (at 65·0-60·2°N), Italy (at 45·6-41·5°N), Scotland (at 58·2-55·1°N) and Spain (at 41·5°N). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as a comparator, the median 25(OH)D concentration was 3·03, 3·28, 5·41, 6·54 and 9·28 ng/ml lower in the German, Finnish, Italian, Scottish and Spanish cohort, respectively (P-value < 0·001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans.",
author = "Viktor Oskarsson and Mats Eliasson and Veikko Salomaa and Jaakko Reinikainen and Satu M{\"a}nnist{\"o} and Luigi Palmieri and Chiara Donfrancesco and Susana Sans and Simona Costanzo and {de Gaetano}, Giovanni and Licia Iacoviello and Giovanni Veronesi and Ferrario, {Marco M} and Teresa Padro and Barbara Thorand and Cornelia Huth and Tanja Zeller and Stefan Blankenberg and Anderson, {Annie S} and Hugh Tunstall-Pedoe and Kari Kuulasmaa and Stefan S{\"o}derberg and {BiomarCaRE Investigators}",
year = "2022",
month = dec,
day = "14",
doi = "10.1017/S0007114521005080",
language = "English",
volume = "128",
pages = "2208--2218",
journal = "BRIT J NUTR",
issn = "0007-1145",
publisher = "Cambridge University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Influence of geographical latitude on vitamin D status: cross-sectional results from the BiomarCaRE consortium

AU - Oskarsson, Viktor

AU - Eliasson, Mats

AU - Salomaa, Veikko

AU - Reinikainen, Jaakko

AU - Männistö, Satu

AU - Palmieri, Luigi

AU - Donfrancesco, Chiara

AU - Sans, Susana

AU - Costanzo, Simona

AU - de Gaetano, Giovanni

AU - Iacoviello, Licia

AU - Veronesi, Giovanni

AU - Ferrario, Marco M

AU - Padro, Teresa

AU - Thorand, Barbara

AU - Huth, Cornelia

AU - Zeller, Tanja

AU - Blankenberg, Stefan

AU - Anderson, Annie S

AU - Tunstall-Pedoe, Hugh

AU - Kuulasmaa, Kari

AU - Söderberg, Stefan

AU - BiomarCaRE Investigators

PY - 2022/12/14

Y1 - 2022/12/14

N2 - Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in six European countries using harmonised immunoassay data from 81 084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48·9 %; median age 50·8 years; examination period 1984-2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65·6-63·8°N), Germany (at 48·4°N), Finland (at 65·0-60·2°N), Italy (at 45·6-41·5°N), Scotland (at 58·2-55·1°N) and Spain (at 41·5°N). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as a comparator, the median 25(OH)D concentration was 3·03, 3·28, 5·41, 6·54 and 9·28 ng/ml lower in the German, Finnish, Italian, Scottish and Spanish cohort, respectively (P-value < 0·001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans.

AB - Even though sunlight is viewed as the most important determinant of 25-hydroxyvitamin D (25(OH)D) status, several European studies have observed higher 25(OH)D concentrations among north-Europeans than south-Europeans. We studied the association between geographical latitude (derived from ecological data) and 25(OH)D status in six European countries using harmonised immunoassay data from 81 084 participants in the Biomarkers for Cardiovascular Risk Assessment in Europe (BiomarCaRE) project (male sex 48·9 %; median age 50·8 years; examination period 1984-2014). Quantile regression models, adjusted for age, sex, decade and calendar week of sampling and time from sampling to analysis, were used for between-country comparisons. Up until the median percentile, the ordering of countries by 25(OH)D status (from highest to lowest) was as follows: Sweden (at 65·6-63·8°N), Germany (at 48·4°N), Finland (at 65·0-60·2°N), Italy (at 45·6-41·5°N), Scotland (at 58·2-55·1°N) and Spain (at 41·5°N). From the 75th percentile and upwards, Finland had higher values than Germany. As an example, using the Swedish cohort as a comparator, the median 25(OH)D concentration was 3·03, 3·28, 5·41, 6·54 and 9·28 ng/ml lower in the German, Finnish, Italian, Scottish and Spanish cohort, respectively (P-value < 0·001 for all comparisons). The ordering of countries was highly consistent in subgroup analyses by sex, age, and decade and season of sampling. In conclusion, we confirmed the previous observation of a north-to-south gradient of 25(OH)D status in Europe, with higher percentile values among north-Europeans than south-Europeans.

U2 - 10.1017/S0007114521005080

DO - 10.1017/S0007114521005080

M3 - SCORING: Journal article

C2 - 34933700

VL - 128

SP - 2208

EP - 2218

JO - BRIT J NUTR

JF - BRIT J NUTR

SN - 0007-1145

IS - 11

ER -