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Influence of gender on cytokine induced depression and treatment. Gender aspects of IFN-α-induced depression.

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Influence of gender on cytokine induced depression and treatment. Gender aspects of IFN-α-induced depression. / Sarkar, Susanne; Kemper, Jonas; Sarkar, Rahul; Brants, Loni; Friebe, Astrid; Spengler, Ulrich; Schläpfer, Thomas; Reimer, Jens; Buggisch, Peter; Ockenga, Johann; Link, Ralph; Rentrop, Michael; Weidenbach, Hans; Fromm, Gwendolyn; Lieb, Klaus; Baumert, Thomas F; Discher, Thomas; Zeuzem, Stefan; Berg, Thomas; Schaefer, Martin.

In: J AFFECT DISORDERS, Vol. 292, 01.09.2021, p. 766-772.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Sarkar, S, Kemper, J, Sarkar, R, Brants, L, Friebe, A, Spengler, U, Schläpfer, T, Reimer, J, Buggisch, P, Ockenga, J, Link, R, Rentrop, M, Weidenbach, H, Fromm, G, Lieb, K, Baumert, TF, Discher, T, Zeuzem, S, Berg, T & Schaefer, M 2021, 'Influence of gender on cytokine induced depression and treatment. Gender aspects of IFN-α-induced depression.', J AFFECT DISORDERS, vol. 292, pp. 766-772. https://doi.org/10.1016/j.jad.2021.05.087

APA

Sarkar, S., Kemper, J., Sarkar, R., Brants, L., Friebe, A., Spengler, U., Schläpfer, T., Reimer, J., Buggisch, P., Ockenga, J., Link, R., Rentrop, M., Weidenbach, H., Fromm, G., Lieb, K., Baumert, T. F., Discher, T., Zeuzem, S., Berg, T., & Schaefer, M. (2021). Influence of gender on cytokine induced depression and treatment. Gender aspects of IFN-α-induced depression. J AFFECT DISORDERS, 292, 766-772. https://doi.org/10.1016/j.jad.2021.05.087

Vancouver

Sarkar S, Kemper J, Sarkar R, Brants L, Friebe A, Spengler U et al. Influence of gender on cytokine induced depression and treatment. Gender aspects of IFN-α-induced depression. J AFFECT DISORDERS. 2021 Sep 1;292:766-772. https://doi.org/10.1016/j.jad.2021.05.087

Bibtex

@article{14fc3f1698a345c7bf082a410e4445b6,
title = "Influence of gender on cytokine induced depression and treatment. Gender aspects of IFN-α-induced depression.",
abstract = "BACKGROUND: Cytokine treatment with Interferon-alpha (IFN-α) represents a clinical model of immune associated depression, but it remains unclear if it is of the same entity as major depressive disorder (MDD). The study focuses on possible gender differences in IFN-α induced depression and effects of a pre-emptive antidepressant treatment.METHODS: Data from 181 patients with chronic hepatitis C infection (cHC) without history of mental illnesses undergoing treatment with IFN-α 2a and ribavirin were re-analyzed for gender effects. Patients with a pre-emptive antidepressant therapy with Escitalopram (n = 90, verum group) to prevent IFN-induced depression were compared to patients who received placebo (n = 91). Depressive symptoms before and during HCV-treatment were assessed using the Montgomery-Asberg Depression Rating Scale (MADRS), Beck's Depression Inventory (BDI) and the Hamilton Anxiety Rating Scale.RESULTS: We found significant differences regarding the incidence and severity of depressive symptoms between men and women for patients without antidepressant pre-treatment (placebo group). Significantly more women without pre-emptive antidepressant therapy suffered from clinically relevant depression (MADRS values ≥ 13, p = 0.041) and self-rated depressive symptoms (BDI ≥ 17, p = 0.024). Antidepressant pre-treatment showed comparable effects regarding the reduction of incidence and severity of depression in both women and men.CONCLUSIONS: Compared to MDD, IFN-alpha-induced depression in patients with cHC is also characterized by gender differences with an increased risk for women but no gender difference regarding the effects of an antidepressant pre-treatment is found. Our data strengthens the hypothesis that Interferon-induced depression serves as a clinical model for immune related depressive disorders.",
keywords = "Antiviral Agents/adverse effects, Cytokines, Depression, Depressive Disorder, Major/chemically induced, Female, Hepatitis C, Chronic/drug therapy, Humans, Interferon-alpha/adverse effects, Male, Ribavirin/therapeutic use",
author = "Susanne Sarkar and Jonas Kemper and Rahul Sarkar and Loni Brants and Astrid Friebe and Ulrich Spengler and Thomas Schl{\"a}pfer and Jens Reimer and Peter Buggisch and Johann Ockenga and Ralph Link and Michael Rentrop and Hans Weidenbach and Gwendolyn Fromm and Klaus Lieb and Baumert, {Thomas F} and Thomas Discher and Stefan Zeuzem and Thomas Berg and Martin Schaefer",
note = "Copyright {\textcopyright} 2021. Published by Elsevier B.V.",
year = "2021",
month = sep,
day = "1",
doi = "10.1016/j.jad.2021.05.087",
language = "English",
volume = "292",
pages = "766--772",
journal = "J AFFECT DISORDERS",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Influence of gender on cytokine induced depression and treatment. Gender aspects of IFN-α-induced depression.

AU - Sarkar, Susanne

AU - Kemper, Jonas

AU - Sarkar, Rahul

AU - Brants, Loni

AU - Friebe, Astrid

AU - Spengler, Ulrich

AU - Schläpfer, Thomas

AU - Reimer, Jens

AU - Buggisch, Peter

AU - Ockenga, Johann

AU - Link, Ralph

AU - Rentrop, Michael

AU - Weidenbach, Hans

AU - Fromm, Gwendolyn

AU - Lieb, Klaus

AU - Baumert, Thomas F

AU - Discher, Thomas

AU - Zeuzem, Stefan

AU - Berg, Thomas

AU - Schaefer, Martin

N1 - Copyright © 2021. Published by Elsevier B.V.

PY - 2021/9/1

Y1 - 2021/9/1

N2 - BACKGROUND: Cytokine treatment with Interferon-alpha (IFN-α) represents a clinical model of immune associated depression, but it remains unclear if it is of the same entity as major depressive disorder (MDD). The study focuses on possible gender differences in IFN-α induced depression and effects of a pre-emptive antidepressant treatment.METHODS: Data from 181 patients with chronic hepatitis C infection (cHC) without history of mental illnesses undergoing treatment with IFN-α 2a and ribavirin were re-analyzed for gender effects. Patients with a pre-emptive antidepressant therapy with Escitalopram (n = 90, verum group) to prevent IFN-induced depression were compared to patients who received placebo (n = 91). Depressive symptoms before and during HCV-treatment were assessed using the Montgomery-Asberg Depression Rating Scale (MADRS), Beck's Depression Inventory (BDI) and the Hamilton Anxiety Rating Scale.RESULTS: We found significant differences regarding the incidence and severity of depressive symptoms between men and women for patients without antidepressant pre-treatment (placebo group). Significantly more women without pre-emptive antidepressant therapy suffered from clinically relevant depression (MADRS values ≥ 13, p = 0.041) and self-rated depressive symptoms (BDI ≥ 17, p = 0.024). Antidepressant pre-treatment showed comparable effects regarding the reduction of incidence and severity of depression in both women and men.CONCLUSIONS: Compared to MDD, IFN-alpha-induced depression in patients with cHC is also characterized by gender differences with an increased risk for women but no gender difference regarding the effects of an antidepressant pre-treatment is found. Our data strengthens the hypothesis that Interferon-induced depression serves as a clinical model for immune related depressive disorders.

AB - BACKGROUND: Cytokine treatment with Interferon-alpha (IFN-α) represents a clinical model of immune associated depression, but it remains unclear if it is of the same entity as major depressive disorder (MDD). The study focuses on possible gender differences in IFN-α induced depression and effects of a pre-emptive antidepressant treatment.METHODS: Data from 181 patients with chronic hepatitis C infection (cHC) without history of mental illnesses undergoing treatment with IFN-α 2a and ribavirin were re-analyzed for gender effects. Patients with a pre-emptive antidepressant therapy with Escitalopram (n = 90, verum group) to prevent IFN-induced depression were compared to patients who received placebo (n = 91). Depressive symptoms before and during HCV-treatment were assessed using the Montgomery-Asberg Depression Rating Scale (MADRS), Beck's Depression Inventory (BDI) and the Hamilton Anxiety Rating Scale.RESULTS: We found significant differences regarding the incidence and severity of depressive symptoms between men and women for patients without antidepressant pre-treatment (placebo group). Significantly more women without pre-emptive antidepressant therapy suffered from clinically relevant depression (MADRS values ≥ 13, p = 0.041) and self-rated depressive symptoms (BDI ≥ 17, p = 0.024). Antidepressant pre-treatment showed comparable effects regarding the reduction of incidence and severity of depression in both women and men.CONCLUSIONS: Compared to MDD, IFN-alpha-induced depression in patients with cHC is also characterized by gender differences with an increased risk for women but no gender difference regarding the effects of an antidepressant pre-treatment is found. Our data strengthens the hypothesis that Interferon-induced depression serves as a clinical model for immune related depressive disorders.

KW - Antiviral Agents/adverse effects

KW - Cytokines

KW - Depression

KW - Depressive Disorder, Major/chemically induced

KW - Female

KW - Hepatitis C, Chronic/drug therapy

KW - Humans

KW - Interferon-alpha/adverse effects

KW - Male

KW - Ribavirin/therapeutic use

U2 - 10.1016/j.jad.2021.05.087

DO - 10.1016/j.jad.2021.05.087

M3 - SCORING: Journal article

C2 - 34171555

VL - 292

SP - 766

EP - 772

JO - J AFFECT DISORDERS

JF - J AFFECT DISORDERS

SN - 0165-0327

ER -