Influence of 3D QCT scan protocol on the QCT-based finite element models of human vertebral cancellous bone
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Influence of 3D QCT scan protocol on the QCT-based finite element models of human vertebral cancellous bone. / Lu, Yongtao; Engelke, Klaus; Püschel, Klaus; Morlock, Michael M; Huber, Gerd.
In: MED ENG PHYS, Vol. 36, No. 8, 01.08.2014, p. 1069-1073.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Influence of 3D QCT scan protocol on the QCT-based finite element models of human vertebral cancellous bone
AU - Lu, Yongtao
AU - Engelke, Klaus
AU - Püschel, Klaus
AU - Morlock, Michael M
AU - Huber, Gerd
N1 - Copyright © 2014 IPEM. Published by Elsevier Ltd. All rights reserved.
PY - 2014/8/1
Y1 - 2014/8/1
N2 - Quantitative computed tomography (QCT)-based finite element (FE) models provide a better prediction of vertebral strength than dual-energy X-ray absorptiometry. However, FE models are often created from datasets acquired at different CT scan protocols and it is unclear whether this influences the FE results. The aim of this paper was to investigate whether there was an effect of the CT scan protocol on the FE models. 12 human thoracolumbar vertebrae were scanned on top of a calcium hydroxyapatite calibration phantom using a standard QCT scan protocol - 120kV, 100mAs (PA); and a low dose protocol - 90kV, 150mAs (PB). FE cancellous models with cuboid volume of interest and inhomogeneous nonlinear bone properties were created. Axial compression was simulated. The apparent BMD, modulus and yield strength showed significant differences between the two scan protocols. The apparent BMD, the modulus and yield strength between the two groups were highly linearly correlated. This paper indicated that the FE models created from image datasets acquired at different X-ray tube voltage settings would give significantly different results and this effect could be possibly corrected using a linear correction approach.
AB - Quantitative computed tomography (QCT)-based finite element (FE) models provide a better prediction of vertebral strength than dual-energy X-ray absorptiometry. However, FE models are often created from datasets acquired at different CT scan protocols and it is unclear whether this influences the FE results. The aim of this paper was to investigate whether there was an effect of the CT scan protocol on the FE models. 12 human thoracolumbar vertebrae were scanned on top of a calcium hydroxyapatite calibration phantom using a standard QCT scan protocol - 120kV, 100mAs (PA); and a low dose protocol - 90kV, 150mAs (PB). FE cancellous models with cuboid volume of interest and inhomogeneous nonlinear bone properties were created. Axial compression was simulated. The apparent BMD, modulus and yield strength showed significant differences between the two scan protocols. The apparent BMD, the modulus and yield strength between the two groups were highly linearly correlated. This paper indicated that the FE models created from image datasets acquired at different X-ray tube voltage settings would give significantly different results and this effect could be possibly corrected using a linear correction approach.
KW - Aged
KW - Aged, 80 and over
KW - Bone Density
KW - Calibration
KW - Compressive Strength
KW - Computer Simulation
KW - Durapatite
KW - Elastic Modulus
KW - Female
KW - Finite Element Analysis
KW - Humans
KW - Linear Models
KW - Models, Biological
KW - Nonlinear Dynamics
KW - Phantoms, Imaging
KW - Radiation Dosage
KW - Thoracic Vertebrae
KW - Tomography, X-Ray Computed
U2 - 10.1016/j.medengphy.2014.05.001
DO - 10.1016/j.medengphy.2014.05.001
M3 - SCORING: Journal article
C2 - 24894031
VL - 36
SP - 1069
EP - 1073
JO - MED ENG PHYS
JF - MED ENG PHYS
SN - 1350-4533
IS - 8
ER -
