Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort study

TY - JOUR

T1 - Inflammatory burden, lifestyle and atherosclerotic cardiovascular disease: insights from a population based cohort study

AU - Bay, Benjamin

AU - Blaum, Christopher

AU - Kellner, Caroline

AU - Bei der Kellen, Ramona

AU - Ojeda, Francisco

AU - Waibel, Julia

AU - Arnold, Natalie

AU - Behrendt, Christian-A

AU - Rimmele, David L

AU - Thomalla, Goetz

AU - Twerenbold, Raphael

AU - Blankenberg, Stefan

AU - Zyriax, Birgit

AU - Brunner, Fabian J

AU - Waldeyer, Christoph

N1 - © 2023. The Author(s).

PY - 2023/12/8

Y1 - 2023/12/8

N2 - The inflammatory burden as measured by high-sensitivity C-reactive Protein (hsCRP) is recognized as a cardiovascular risk factor, which can however be affected by lifestyle-related risk factors (LRF). Up-to-date the interplay between hsCRP, LRF and presence and extent of atherosclerotic disease is still largely unknown, which we therefore sought to investigate in a contemporary population-based cohort. We included participants from the cross-sectional population-based Hamburg City Health Study. Affected vascular beds were defined as coronary, peripheral, and cerebrovascular arteries. LRF considered were lack of physical activity, overweight, active smoking and poor adherence to a Mediterranean diet. We computed multivariable analyses with hsCRP as the dependent variable and LRF as covariates according to the number of vascular beds affected. In the 6765 individuals available for analysis, we found a stepwise increase of hsCRP concentration both according to the number of LRF present as well as the number of vascular beds affected. Adjusted regression analyses showed an independent association between increasing numbers of LRF with hsCRP levels across the extent of atherosclerosis. We demonstrate increasing hsCRP concentrations according to both the number of LRF as well as the extent of atherosclerosis, emphasizing the necessity of lifestyle-related risk factor optimization.

AB - The inflammatory burden as measured by high-sensitivity C-reactive Protein (hsCRP) is recognized as a cardiovascular risk factor, which can however be affected by lifestyle-related risk factors (LRF). Up-to-date the interplay between hsCRP, LRF and presence and extent of atherosclerotic disease is still largely unknown, which we therefore sought to investigate in a contemporary population-based cohort. We included participants from the cross-sectional population-based Hamburg City Health Study. Affected vascular beds were defined as coronary, peripheral, and cerebrovascular arteries. LRF considered were lack of physical activity, overweight, active smoking and poor adherence to a Mediterranean diet. We computed multivariable analyses with hsCRP as the dependent variable and LRF as covariates according to the number of vascular beds affected. In the 6765 individuals available for analysis, we found a stepwise increase of hsCRP concentration both according to the number of LRF present as well as the number of vascular beds affected. Adjusted regression analyses showed an independent association between increasing numbers of LRF with hsCRP levels across the extent of atherosclerosis. We demonstrate increasing hsCRP concentrations according to both the number of LRF as well as the extent of atherosclerosis, emphasizing the necessity of lifestyle-related risk factor optimization.

U2 - 10.1038/s41598-023-48602-7

DO - 10.1038/s41598-023-48602-7

M3 - SCORING: Journal article

C2 - 38066176

VL - 13

SP - 21761

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -