Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota

Nicola Gagliani; Noah W Palm; Marcel R de Zoete; Richard A Flavell

doi:10.1093/intimm/dxu066

Inflammasomes and intestinal homeostasis

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Inflammasomes and intestinal homeostasis : regulating and connecting infection, inflammation and the microbiota. / Gagliani, Nicola; Palm, Noah W; de Zoete, Marcel R; Flavell, Richard A.

In: International immunology, Vol. 26, No. 9, 09.2014, p. 495-9.

Research output: SCORING: Contribution to journal › SCORING: Review article › Research

Harvard

Gagliani, N, Palm, NW, de Zoete, MR & Flavell, RA 2014, 'Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota', International immunology, vol. 26, no. 9, pp. 495-9. https://doi.org/10.1093/intimm/dxu066

APA

Gagliani, N., Palm, N. W., de Zoete, M. R., & Flavell, R. A. (2014). Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota. International immunology, 26(9), 495-9. https://doi.org/10.1093/intimm/dxu066

Vancouver

Gagliani N, Palm NW, de Zoete MR, Flavell RA. Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota. International immunology. 2014 Sep;26(9):495-9. https://doi.org/10.1093/intimm/dxu066

Bibtex

@article{c7f9bdb036e141ea81aed967fe83754b,

title = "Inflammasomes and intestinal homeostasis: regulating and connecting infection, inflammation and the microbiota",

abstract = "Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many conflicting studies have been published regarding the effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt to reconcile these contrasting data by highlighting the many ways that the inflammasome contributes to intestinal homeostasis and pathology and exploring the potential role of alterations in the microbiota in these conflicting studies.",

keywords = "Animals, Homeostasis, Humans, Inflammasomes, Inflammation, Intestines, Microbiota, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review",

author = "Nicola Gagliani and Palm, {Noah W} and {de Zoete}, {Marcel R} and Flavell, {Richard A}",

year = "2014",

month = sep,

doi = "10.1093/intimm/dxu066",

language = "English",

volume = "26",

pages = "495--9",

journal = "INT IMMUNOL",

issn = "0953-8178",

publisher = "Oxford University Press",

number = "9",

}

RIS

TY - JOUR

T1 - Inflammasomes and intestinal homeostasis

T2 - regulating and connecting infection, inflammation and the microbiota

AU - Gagliani, Nicola

AU - Palm, Noah W

AU - de Zoete, Marcel R

AU - Flavell, Richard A

PY - 2014/9

Y1 - 2014/9

N2 - Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many conflicting studies have been published regarding the effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt to reconcile these contrasting data by highlighting the many ways that the inflammasome contributes to intestinal homeostasis and pathology and exploring the potential role of alterations in the microbiota in these conflicting studies.

AB - Inflammasomes are large cytosolic protein complexes that detect infection and stress-associated signals and promote immediate inflammatory responses. In the intestine, activation of the inflammasome leads to an inflammatory response that is important for controlling enteric infections but can also result in pathological tissue damage. Recent studies have suggested that the inflammasome also regulates intestinal homeostasis through its effects on the intestinal microbiota. Notably, many conflicting studies have been published regarding the effect of inflammasome deficiencies on intestinal homeostasis. Here, we attempt to reconcile these contrasting data by highlighting the many ways that the inflammasome contributes to intestinal homeostasis and pathology and exploring the potential role of alterations in the microbiota in these conflicting studies.

KW - Animals

KW - Homeostasis

KW - Humans

KW - Inflammasomes

KW - Inflammation

KW - Intestines

KW - Microbiota

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1093/intimm/dxu066

DO - 10.1093/intimm/dxu066

M3 - SCORING: Review article

C2 - 24948595

VL - 26

SP - 495

EP - 499

JO - INT IMMUNOL

JF - INT IMMUNOL

SN - 0953-8178

IS - 9

ER -