Research ExplorerPublicationsInfections complicating severe alcoholic Hepatitis: Enteroco...

Infections complicating severe alcoholic Hepatitis: Enterococcus species represent the most frequently identified pathogen

Standard

Infections complicating severe alcoholic Hepatitis: Enterococcus species represent the most frequently identified pathogen. / Beisel, Claudia; Blessin, Usha ; Schulze Zur Wiesch, Julian; Wehmeyer, Malte H; Lohse, Ansgar W; Benten, Daniel; Kluwe, Johannes.

In: SCAND J GASTROENTERO, Vol. 51, No. 7, 07.2016, p. 807-13.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Beisel, C, Blessin, U, Schulze Zur Wiesch, J, Wehmeyer, MH, Lohse, AW, Benten, D & Kluwe, J 2016, 'Infections complicating severe alcoholic Hepatitis: Enterococcus species represent the most frequently identified pathogen', SCAND J GASTROENTERO, vol. 51, no. 7, pp. 807-13. https://doi.org/10.3109/00365521.2016.1157887

APA

Beisel, C., Blessin, U., Schulze Zur Wiesch, J., Wehmeyer, M. H., Lohse, A. W., Benten, D., & Kluwe, J. (2016). Infections complicating severe alcoholic Hepatitis: Enterococcus species represent the most frequently identified pathogen. SCAND J GASTROENTERO, 51(7), 807-13. https://doi.org/10.3109/00365521.2016.1157887

Vancouver

Beisel C, Blessin U, Schulze Zur Wiesch J, Wehmeyer MH, Lohse AW, Benten D et al. Infections complicating severe alcoholic Hepatitis: Enterococcus species represent the most frequently identified pathogen. SCAND J GASTROENTERO. 2016 Jul;51(7):807-13. https://doi.org/10.3109/00365521.2016.1157887

Bibtex

@article{dd60b96bac414d3dbbf49e7866d36035,
title = "Infections complicating severe alcoholic Hepatitis: Enterococcus species represent the most frequently identified pathogen",
abstract = "BACKGROUND: Patients with acute alcoholic steatohepatitis are at a high risk for infections. To date, neither disease-specific pathogen patterns, nor typical sites of infection, nor antibiotic treatment strategies have been established for AH.AIMS: To characterize incidence of infections, pathogen spectrum, sites of infection, and related mortality of patients with AH under steroid therapy.METHODS: We retrospectively analyzed clinical data of 73 patients with severe alcoholic hepatitis (MELD ≥ 20).RESULTS: Infections were detected in 45 patients (73%). Patients who developed an infection after initiation of corticosteroid therapy had a higher 6-month mortality than patients without onset of infection after initiation of corticosteroid treatment (44% versus 24%, p = 0.116). The pathogen identified most frequently was Enterococcus species.DISCUSSION: Infections frequently complicate severe alcoholic hepatitis and affect survival. The high rate of Enterococcus infections suggests that commonly used antibiotics, such as cephalosporins and quinolones, may represent an ineffective choice of empiric antibiotic treatment for complicated AH.",
author = "Claudia Beisel and Usha Blessin and {Schulze Zur Wiesch}, Julian and Wehmeyer, {Malte H} and Lohse, {Ansgar W} and Daniel Benten and Johannes Kluwe",
year = "2016",
month = jul,
doi = "10.3109/00365521.2016.1157887",
language = "English",
volume = "51",
pages = "807--13",
journal = "SCAND J GASTROENTERO",
issn = "0036-5521",
publisher = "informa healthcare",
number = "7",

}

RIS

TY - JOUR

T1 - Infections complicating severe alcoholic Hepatitis: Enterococcus species represent the most frequently identified pathogen

AU - Beisel, Claudia

AU - Blessin, Usha

AU - Schulze Zur Wiesch, Julian

AU - Wehmeyer, Malte H

AU - Lohse, Ansgar W

AU - Benten, Daniel

AU - Kluwe, Johannes

PY - 2016/7

Y1 - 2016/7

N2 - BACKGROUND: Patients with acute alcoholic steatohepatitis are at a high risk for infections. To date, neither disease-specific pathogen patterns, nor typical sites of infection, nor antibiotic treatment strategies have been established for AH.AIMS: To characterize incidence of infections, pathogen spectrum, sites of infection, and related mortality of patients with AH under steroid therapy.METHODS: We retrospectively analyzed clinical data of 73 patients with severe alcoholic hepatitis (MELD ≥ 20).RESULTS: Infections were detected in 45 patients (73%). Patients who developed an infection after initiation of corticosteroid therapy had a higher 6-month mortality than patients without onset of infection after initiation of corticosteroid treatment (44% versus 24%, p = 0.116). The pathogen identified most frequently was Enterococcus species.DISCUSSION: Infections frequently complicate severe alcoholic hepatitis and affect survival. The high rate of Enterococcus infections suggests that commonly used antibiotics, such as cephalosporins and quinolones, may represent an ineffective choice of empiric antibiotic treatment for complicated AH.

AB - BACKGROUND: Patients with acute alcoholic steatohepatitis are at a high risk for infections. To date, neither disease-specific pathogen patterns, nor typical sites of infection, nor antibiotic treatment strategies have been established for AH.AIMS: To characterize incidence of infections, pathogen spectrum, sites of infection, and related mortality of patients with AH under steroid therapy.METHODS: We retrospectively analyzed clinical data of 73 patients with severe alcoholic hepatitis (MELD ≥ 20).RESULTS: Infections were detected in 45 patients (73%). Patients who developed an infection after initiation of corticosteroid therapy had a higher 6-month mortality than patients without onset of infection after initiation of corticosteroid treatment (44% versus 24%, p = 0.116). The pathogen identified most frequently was Enterococcus species.DISCUSSION: Infections frequently complicate severe alcoholic hepatitis and affect survival. The high rate of Enterococcus infections suggests that commonly used antibiotics, such as cephalosporins and quinolones, may represent an ineffective choice of empiric antibiotic treatment for complicated AH.

U2 - 10.3109/00365521.2016.1157887

DO - 10.3109/00365521.2016.1157887

M3 - SCORING: Journal article

C2 - 27000534

VL - 51

SP - 807

EP - 813

JO - SCAND J GASTROENTERO

JF - SCAND J GASTROENTERO

SN - 0036-5521

IS - 7

ER -