Infection control management and surveillance of carbapenem-resistant Gram-negative bacteria in hematopoietic stem cell recipients
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Infection control management and surveillance of carbapenem-resistant Gram-negative bacteria in hematopoietic stem cell recipients. / Baier, Claas; Beck, Maleen; Panagiota, Viktoria; Lueck, Catherina; Kharazipour, Daniel; Hintze, Sophie Charlotte; Bollin, Robin; Ebadi, Ella; Ziesing, Stefan; Eder, Matthias; Bange, Franz-Christoph; Beutel, Gernot.
In: ANTIMICROB RESIST IN, Vol. 8, 2019, p. 160.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Infection control management and surveillance of carbapenem-resistant Gram-negative bacteria in hematopoietic stem cell recipients
AU - Baier, Claas
AU - Beck, Maleen
AU - Panagiota, Viktoria
AU - Lueck, Catherina
AU - Kharazipour, Daniel
AU - Hintze, Sophie Charlotte
AU - Bollin, Robin
AU - Ebadi, Ella
AU - Ziesing, Stefan
AU - Eder, Matthias
AU - Bange, Franz-Christoph
AU - Beutel, Gernot
N1 - © The Author(s). 2019.
PY - 2019
Y1 - 2019
N2 - Hematopoietic stem cell transplantation (HSCT) is a curative treatment option for selected diseases of the hematopoietic system. In the context of HSCT, bloodstream infections caused by Gram-negative bacteria (GNB) significantly contribute to morbidity and mortality. Antibiotic treatment of bloodstream infections with carbapenem-resistant (CR) GNB presents a particular challenge. As a part of our infection control management, the admission of a patient who was known to be colonized with a CR Acinetobacter baumannii triggered an active weekly screening of all patients to determine the prevalence and potential transmission of CR GNB and CR Acinetobacter baumannii in particular. Over a 3 month period a total of 71 patients were regularly screened for colonization with CR GNB. Including the index patient, a total of three patients showed CR GNB colonization representing a prevalence of 4.2%. Nosocomial transmission of CR Acinetobacter baumannii or other CR GNB was not observed. However, the index patient developed a subsequent bloodstream infection with the CR Acinetobacter baumannii, therefore empiric antibiotic therapy based on the known resistance profile was initiated. A weekly prevalence screening for CR GNB might be an effective monitoring tool for potential transmission, may enhance existing infection control management concepts and may support the decision making for empiric antibiotic therapy.
AB - Hematopoietic stem cell transplantation (HSCT) is a curative treatment option for selected diseases of the hematopoietic system. In the context of HSCT, bloodstream infections caused by Gram-negative bacteria (GNB) significantly contribute to morbidity and mortality. Antibiotic treatment of bloodstream infections with carbapenem-resistant (CR) GNB presents a particular challenge. As a part of our infection control management, the admission of a patient who was known to be colonized with a CR Acinetobacter baumannii triggered an active weekly screening of all patients to determine the prevalence and potential transmission of CR GNB and CR Acinetobacter baumannii in particular. Over a 3 month period a total of 71 patients were regularly screened for colonization with CR GNB. Including the index patient, a total of three patients showed CR GNB colonization representing a prevalence of 4.2%. Nosocomial transmission of CR Acinetobacter baumannii or other CR GNB was not observed. However, the index patient developed a subsequent bloodstream infection with the CR Acinetobacter baumannii, therefore empiric antibiotic therapy based on the known resistance profile was initiated. A weekly prevalence screening for CR GNB might be an effective monitoring tool for potential transmission, may enhance existing infection control management concepts and may support the decision making for empiric antibiotic therapy.
KW - Adult
KW - Aged
KW - Anti-Bacterial Agents/pharmacology
KW - Carbapenems/pharmacology
KW - Female
KW - Gram-Negative Bacteria/drug effects
KW - Gram-Negative Bacterial Infections/epidemiology
KW - Hematopoietic Stem Cell Transplantation/adverse effects
KW - Humans
KW - Infection Control
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Public Health Surveillance
KW - Transplant Recipients
KW - beta-Lactam Resistance
U2 - 10.1186/s13756-019-0606-3
DO - 10.1186/s13756-019-0606-3
M3 - SCORING: Journal article
C2 - 31649817
VL - 8
SP - 160
JO - ANTIMICROB RESIST IN
JF - ANTIMICROB RESIST IN
SN - 2047-2994
ER -
