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Induction of periimplantitis in dental implants

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Induction of periimplantitis in dental implants. / Becker, Stephan T; Föge, Marc; Beck-Broichsitter, Benedicta E; Gavrilova, Olga; Bolte, Hendrik; Rosenstiel, Philipp; Wiltfang, Jörg.

In: J CRANIOFAC SURG, Vol. 24, No. 1, 01.01.2013, p. e15-8.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Becker, ST, Föge, M, Beck-Broichsitter, BE, Gavrilova, O, Bolte, H, Rosenstiel, P & Wiltfang, J 2013, 'Induction of periimplantitis in dental implants', J CRANIOFAC SURG, vol. 24, no. 1, pp. e15-8. https://doi.org/10.1097/SCS.0b013e318266fb2d

APA

Becker, S. T., Föge, M., Beck-Broichsitter, B. E., Gavrilova, O., Bolte, H., Rosenstiel, P., & Wiltfang, J. (2013). Induction of periimplantitis in dental implants. J CRANIOFAC SURG, 24(1), e15-8. https://doi.org/10.1097/SCS.0b013e318266fb2d

Vancouver

Becker ST, Föge M, Beck-Broichsitter BE, Gavrilova O, Bolte H, Rosenstiel P et al. Induction of periimplantitis in dental implants. J CRANIOFAC SURG. 2013 Jan 1;24(1):e15-8. https://doi.org/10.1097/SCS.0b013e318266fb2d

Bibtex

@article{44c4522958e641acb9b4d4a648aaf15d,
title = "Induction of periimplantitis in dental implants",
abstract = "Development, progression, and therapy of periimplantitis are nonresolved emerging problems. The aim of this pilot study was to establish a model for periimplantitis in mice to have a base for tests with immune-deficient knockout organisms to improve the knowledge about development and progression of periimplantitis and to develop further therapeutic options.In 8 mice, titanium implants were inserted in the median of the palate. Four of these implants had ligatures (periimplantitis group). After 2 weeks, the animals received a special diet enriched with sugar and flavor. After 9 weeks, micro-computed tomography (micro-CT) examinations to evaluate the periimplant tissue and histologies were performed.Dental implant insertions within the oral cavity are possible in living mice. Implants with ligatures showed significantly larger periimplant bone defects than controls. The radiologic findings were confirmed by histology. At the end of the observation period, the portion of implants lost was higher in the ligature group.This is the first publication to describe the insertion of dental implants in living mice. In addition, it is the first time that periimplant infection could be induced in that species. This model will pave the way to study knockout mice with reduced or even enhanced resistance to periimplantitis.",
keywords = "Animals, Dental Implantation, Endosseous, Dental Implants, Disease Models, Animal, Ligation, Male, Mice, Mice, Inbred C57BL, Peri-Implantitis, Pilot Projects, Titanium, X-Ray Microtomography",
author = "Becker, {Stephan T} and Marc F{\"o}ge and Beck-Broichsitter, {Benedicta E} and Olga Gavrilova and Hendrik Bolte and Philipp Rosenstiel and J{\"o}rg Wiltfang",
year = "2013",
month = jan,
day = "1",
doi = "10.1097/SCS.0b013e318266fb2d",
language = "English",
volume = "24",
pages = "e15--8",
journal = "J CRANIOFAC SURG",
issn = "1049-2275",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Induction of periimplantitis in dental implants

AU - Becker, Stephan T

AU - Föge, Marc

AU - Beck-Broichsitter, Benedicta E

AU - Gavrilova, Olga

AU - Bolte, Hendrik

AU - Rosenstiel, Philipp

AU - Wiltfang, Jörg

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Development, progression, and therapy of periimplantitis are nonresolved emerging problems. The aim of this pilot study was to establish a model for periimplantitis in mice to have a base for tests with immune-deficient knockout organisms to improve the knowledge about development and progression of periimplantitis and to develop further therapeutic options.In 8 mice, titanium implants were inserted in the median of the palate. Four of these implants had ligatures (periimplantitis group). After 2 weeks, the animals received a special diet enriched with sugar and flavor. After 9 weeks, micro-computed tomography (micro-CT) examinations to evaluate the periimplant tissue and histologies were performed.Dental implant insertions within the oral cavity are possible in living mice. Implants with ligatures showed significantly larger periimplant bone defects than controls. The radiologic findings were confirmed by histology. At the end of the observation period, the portion of implants lost was higher in the ligature group.This is the first publication to describe the insertion of dental implants in living mice. In addition, it is the first time that periimplant infection could be induced in that species. This model will pave the way to study knockout mice with reduced or even enhanced resistance to periimplantitis.

AB - Development, progression, and therapy of periimplantitis are nonresolved emerging problems. The aim of this pilot study was to establish a model for periimplantitis in mice to have a base for tests with immune-deficient knockout organisms to improve the knowledge about development and progression of periimplantitis and to develop further therapeutic options.In 8 mice, titanium implants were inserted in the median of the palate. Four of these implants had ligatures (periimplantitis group). After 2 weeks, the animals received a special diet enriched with sugar and flavor. After 9 weeks, micro-computed tomography (micro-CT) examinations to evaluate the periimplant tissue and histologies were performed.Dental implant insertions within the oral cavity are possible in living mice. Implants with ligatures showed significantly larger periimplant bone defects than controls. The radiologic findings were confirmed by histology. At the end of the observation period, the portion of implants lost was higher in the ligature group.This is the first publication to describe the insertion of dental implants in living mice. In addition, it is the first time that periimplant infection could be induced in that species. This model will pave the way to study knockout mice with reduced or even enhanced resistance to periimplantitis.

KW - Animals

KW - Dental Implantation, Endosseous

KW - Dental Implants

KW - Disease Models, Animal

KW - Ligation

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Peri-Implantitis

KW - Pilot Projects

KW - Titanium

KW - X-Ray Microtomography

U2 - 10.1097/SCS.0b013e318266fb2d

DO - 10.1097/SCS.0b013e318266fb2d

M3 - SCORING: Journal article

C2 - 23348321

VL - 24

SP - e15-8

JO - J CRANIOFAC SURG

JF - J CRANIOFAC SURG

SN - 1049-2275

IS - 1

ER -