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Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice

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Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice. / Barikbin, Roja; Neureiter, Daniel; Wirth, Jan; Erhardt, Annette; Schwinge, Dorothee; Kluwe, Johannes; Schramm, Christoph; Tiegs, Gisa; Sass, Gabriele.

In: HEPATOLOGY, Vol. 55, No. 2, 2, 02.2012, p. 553-562.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Barikbin, R, Neureiter, D, Wirth, J, Erhardt, A, Schwinge, D, Kluwe, J, Schramm, C, Tiegs, G & Sass, G 2012, 'Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice', HEPATOLOGY, vol. 55, no. 2, 2, pp. 553-562. https://doi.org/10.1002/hep.24711

APA

Barikbin, R., Neureiter, D., Wirth, J., Erhardt, A., Schwinge, D., Kluwe, J., Schramm, C., Tiegs, G., & Sass, G. (2012). Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice. HEPATOLOGY, 55(2), 553-562. [2]. https://doi.org/10.1002/hep.24711

Vancouver

Barikbin R, Neureiter D, Wirth J, Erhardt A, Schwinge D, Kluwe J et al. Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice. HEPATOLOGY. 2012 Feb;55(2):553-562. 2. https://doi.org/10.1002/hep.24711

Bibtex

@article{09180e706cb4463a831f4e12f3c2ff4d,
title = "Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice",
abstract = "Induction or overexpression of the heme-degrading enzyme, heme oxygenase 1 (HO-1), has been shown to protect mice from liver damage induced by acute inflammation. We have investigated the effects of HO-1 induction in a mouse model of chronic liver inflammation and fibrogenesis with progression to hepatocellular carcinoma (HCC) (Mdr2ko; FVB.129P2-Abcb4(tm1Bor)). HO-1 was induced in vivo by treatment with cobalt protoporphyrin IX, starting at week 5 or 12 of mice lifespan, and continued for 7 weeks. Our results showed that HO-1 induction reduced liver damage and chronic inflammation by regulating immune cell infiltration or proliferation as well as tumor necrosis factor receptor signaling. Fibrosis progression was significantly reduced by HO-1 induction in mice with mild, as well as established, portal and lobular fibrosis. HO-1 induction significantly suppressed hepatic stellate cell activation. During established fibrosis, HO-1 induction was able to revert portal inflammation and fibrosis below levels observed at the start of treatment. Moreover, hepatocellular proliferation and signs of dysplasia were decreased after HO-1 induction. CONCLUSION: Induction of HO-1 interferes with chronic inflammation and fibrogenesis and, in consequence, might delay progression to HCC.",
keywords = "Animals, Female, Disease Progression, Mice, Mice, Knockout, Phosphorylation, Cell Proliferation, Extracellular Signal-Regulated MAP Kinases/metabolism, Heme Oxygenase-1/*metabolism, Liver Cirrhosis/*enzymology/immunology, Membrane Proteins/*metabolism, P-Glycoproteins/genetics, Protoporphyrins, Receptors, Tumor Necrosis Factor/metabolism, Animals, Female, Disease Progression, Mice, Mice, Knockout, Phosphorylation, Cell Proliferation, Extracellular Signal-Regulated MAP Kinases/metabolism, Heme Oxygenase-1/*metabolism, Liver Cirrhosis/*enzymology/immunology, Membrane Proteins/*metabolism, P-Glycoproteins/genetics, Protoporphyrins, Receptors, Tumor Necrosis Factor/metabolism",
author = "Roja Barikbin and Daniel Neureiter and Jan Wirth and Annette Erhardt and Dorothee Schwinge and Johannes Kluwe and Christoph Schramm and Gisa Tiegs and Gabriele Sass",
note = "Copyright {\textcopyright} 2011 American Association for the Study of Liver Diseases.",
year = "2012",
month = feb,
doi = "10.1002/hep.24711",
language = "English",
volume = "55",
pages = "553--562",
journal = "HEPATOLOGY",
issn = "0270-9139",
publisher = "John Wiley and Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Induction of heme oxygenase 1 prevents progression of liver fibrosis in Mdr2 knockout mice

AU - Barikbin, Roja

AU - Neureiter, Daniel

AU - Wirth, Jan

AU - Erhardt, Annette

AU - Schwinge, Dorothee

AU - Kluwe, Johannes

AU - Schramm, Christoph

AU - Tiegs, Gisa

AU - Sass, Gabriele

N1 - Copyright © 2011 American Association for the Study of Liver Diseases.

PY - 2012/2

Y1 - 2012/2

N2 - Induction or overexpression of the heme-degrading enzyme, heme oxygenase 1 (HO-1), has been shown to protect mice from liver damage induced by acute inflammation. We have investigated the effects of HO-1 induction in a mouse model of chronic liver inflammation and fibrogenesis with progression to hepatocellular carcinoma (HCC) (Mdr2ko; FVB.129P2-Abcb4(tm1Bor)). HO-1 was induced in vivo by treatment with cobalt protoporphyrin IX, starting at week 5 or 12 of mice lifespan, and continued for 7 weeks. Our results showed that HO-1 induction reduced liver damage and chronic inflammation by regulating immune cell infiltration or proliferation as well as tumor necrosis factor receptor signaling. Fibrosis progression was significantly reduced by HO-1 induction in mice with mild, as well as established, portal and lobular fibrosis. HO-1 induction significantly suppressed hepatic stellate cell activation. During established fibrosis, HO-1 induction was able to revert portal inflammation and fibrosis below levels observed at the start of treatment. Moreover, hepatocellular proliferation and signs of dysplasia were decreased after HO-1 induction. CONCLUSION: Induction of HO-1 interferes with chronic inflammation and fibrogenesis and, in consequence, might delay progression to HCC.

AB - Induction or overexpression of the heme-degrading enzyme, heme oxygenase 1 (HO-1), has been shown to protect mice from liver damage induced by acute inflammation. We have investigated the effects of HO-1 induction in a mouse model of chronic liver inflammation and fibrogenesis with progression to hepatocellular carcinoma (HCC) (Mdr2ko; FVB.129P2-Abcb4(tm1Bor)). HO-1 was induced in vivo by treatment with cobalt protoporphyrin IX, starting at week 5 or 12 of mice lifespan, and continued for 7 weeks. Our results showed that HO-1 induction reduced liver damage and chronic inflammation by regulating immune cell infiltration or proliferation as well as tumor necrosis factor receptor signaling. Fibrosis progression was significantly reduced by HO-1 induction in mice with mild, as well as established, portal and lobular fibrosis. HO-1 induction significantly suppressed hepatic stellate cell activation. During established fibrosis, HO-1 induction was able to revert portal inflammation and fibrosis below levels observed at the start of treatment. Moreover, hepatocellular proliferation and signs of dysplasia were decreased after HO-1 induction. CONCLUSION: Induction of HO-1 interferes with chronic inflammation and fibrogenesis and, in consequence, might delay progression to HCC.

KW - Animals

KW - Female

KW - Disease Progression

KW - Mice

KW - Mice, Knockout

KW - Phosphorylation

KW - Cell Proliferation

KW - Extracellular Signal-Regulated MAP Kinases/metabolism

KW - Heme Oxygenase-1/metabolism

KW - Liver Cirrhosis/enzymology/immunology

KW - Membrane Proteins/metabolism

KW - P-Glycoproteins/genetics

KW - Protoporphyrins

KW - Receptors, Tumor Necrosis Factor/metabolism

KW - Animals

KW - Female

KW - Disease Progression

KW - Mice

KW - Mice, Knockout

KW - Phosphorylation

KW - Cell Proliferation

KW - Extracellular Signal-Regulated MAP Kinases/metabolism

KW - Heme Oxygenase-1/metabolism

KW - Liver Cirrhosis/enzymology/immunology

KW - Membrane Proteins/metabolism

KW - P-Glycoproteins/genetics

KW - Protoporphyrins

KW - Receptors, Tumor Necrosis Factor/metabolism

U2 - 10.1002/hep.24711

DO - 10.1002/hep.24711

M3 - SCORING: Journal article

C2 - 21953613

VL - 55

SP - 553

EP - 562

JO - HEPATOLOGY

JF - HEPATOLOGY

SN - 0270-9139

IS - 2

M1 - 2

ER -