Individualized metacognitive therapy for delusions. A randomized controlled rater-blind study

Christina Andreou; Charlotte E Wittekind; Martina Fieker; Ulrike Heitz; Ruth Veckenstedt; Francesca Bohn; Steffen Moritz

doi:10.1016/j.jbtep.2016.11.013

Individualized metacognitive therapy for delusions. A randomized controlled rater-blind study

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Individualized metacognitive therapy for delusions. A randomized controlled rater-blind study. / Andreou, Christina; Wittekind, Charlotte E; Fieker, Martina; Heitz, Ulrike; Veckenstedt, Ruth; Bohn, Francesca; Moritz, Steffen.

In: J BEHAV THER EXP PSY, Vol. 56, No. SI, 09.2017, p. 144-151.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Andreou, C, Wittekind, CE, Fieker, M, Heitz, U, Veckenstedt, R, Bohn, F & Moritz, S 2017, 'Individualized metacognitive therapy for delusions. A randomized controlled rater-blind study', J BEHAV THER EXP PSY, vol. 56, no. SI, pp. 144-151. https://doi.org/10.1016/j.jbtep.2016.11.013

APA

Andreou, C., Wittekind, C. E., Fieker, M., Heitz, U., Veckenstedt, R., Bohn, F., & Moritz, S. (2017). Individualized metacognitive therapy for delusions. A randomized controlled rater-blind study. J BEHAV THER EXP PSY, 56(SI), 144-151. https://doi.org/10.1016/j.jbtep.2016.11.013

Vancouver

Andreou C, Wittekind CE, Fieker M, Heitz U, Veckenstedt R, Bohn F et al. Individualized metacognitive therapy for delusions. A randomized controlled rater-blind study. J BEHAV THER EXP PSY. 2017 Sep;56(SI):144-151. https://doi.org/10.1016/j.jbtep.2016.11.013

Bibtex

@article{4973c3c9c12d481cbe6aee243ac8a618,

title = "Individualized metacognitive therapy for delusions. A randomized controlled rater-blind study",

abstract = "BACKGROUND: Theory-driven interventions targeting specific factors that contribute to delusions are receiving increased interest. The present study aimed to assess the efficacy of individualized metacognitive therapy (MCT+), a short manualized intervention that addresses delusion-associated cognitive biases.METHODS: 92 patients with current or past delusions were randomized to receive 12 twice-weekly sessions of either MCT+ or a control intervention within a randomized controlled rater-blind design. Psychopathology and cognitive biases were assessed at baseline, 6 weeks and 6 months. ANCOVAs adjusted for baseline scores were used to assess differences between groups regarding outcome variables. Both per-protocol and intention-to-treat analyses were conducted.RESULTS: At 6 weeks, there was a significant difference in favor of MCT+ regarding decrease in delusion severity and improvement of self-reflectiveness (medium effect size), and a trend-wise difference regarding probability thresholds to decision. These effects increased, when only patients attending a minimum of 4 therapy sessions were considered. Control group patients subsequently showed further improvement while patients in the MCT+ group remained stable, such that there were no differences between groups at the 6-month follow-up.LIMITATIONS: Lower attendance rates in the control group possibly leading to unequal therapeutic effort; lower baseline delusion severity in the MCT+ group.CONCLUSIONS: The result pattern suggests that MCT+ led to earlier improvement in delusions and cognitive biases compared to the control intervention. The absence of a long-term effect might reflect floor effects in the MCT+ group, but may also indicate the need for further measures to promote sustainability of MCT+ effects.",

keywords = "Journal Article",

author = "Christina Andreou and Wittekind, {Charlotte E} and Martina Fieker and Ulrike Heitz and Ruth Veckenstedt and Francesca Bohn and Steffen Moritz",

year = "2017",

month = sep,

doi = "10.1016/j.jbtep.2016.11.013",

language = "English",

volume = "56",

pages = "144--151",

journal = "J BEHAV THER EXP PSY",

issn = "0005-7916",

publisher = "Elsevier Limited",

number = "SI",

}

RIS

TY - JOUR

T1 - Individualized metacognitive therapy for delusions. A randomized controlled rater-blind study

AU - Andreou, Christina

AU - Wittekind, Charlotte E

AU - Fieker, Martina

AU - Heitz, Ulrike

AU - Veckenstedt, Ruth

AU - Bohn, Francesca

AU - Moritz, Steffen

PY - 2017/9

Y1 - 2017/9

N2 - BACKGROUND: Theory-driven interventions targeting specific factors that contribute to delusions are receiving increased interest. The present study aimed to assess the efficacy of individualized metacognitive therapy (MCT+), a short manualized intervention that addresses delusion-associated cognitive biases.METHODS: 92 patients with current or past delusions were randomized to receive 12 twice-weekly sessions of either MCT+ or a control intervention within a randomized controlled rater-blind design. Psychopathology and cognitive biases were assessed at baseline, 6 weeks and 6 months. ANCOVAs adjusted for baseline scores were used to assess differences between groups regarding outcome variables. Both per-protocol and intention-to-treat analyses were conducted.RESULTS: At 6 weeks, there was a significant difference in favor of MCT+ regarding decrease in delusion severity and improvement of self-reflectiveness (medium effect size), and a trend-wise difference regarding probability thresholds to decision. These effects increased, when only patients attending a minimum of 4 therapy sessions were considered. Control group patients subsequently showed further improvement while patients in the MCT+ group remained stable, such that there were no differences between groups at the 6-month follow-up.LIMITATIONS: Lower attendance rates in the control group possibly leading to unequal therapeutic effort; lower baseline delusion severity in the MCT+ group.CONCLUSIONS: The result pattern suggests that MCT+ led to earlier improvement in delusions and cognitive biases compared to the control intervention. The absence of a long-term effect might reflect floor effects in the MCT+ group, but may also indicate the need for further measures to promote sustainability of MCT+ effects.

AB - BACKGROUND: Theory-driven interventions targeting specific factors that contribute to delusions are receiving increased interest. The present study aimed to assess the efficacy of individualized metacognitive therapy (MCT+), a short manualized intervention that addresses delusion-associated cognitive biases.METHODS: 92 patients with current or past delusions were randomized to receive 12 twice-weekly sessions of either MCT+ or a control intervention within a randomized controlled rater-blind design. Psychopathology and cognitive biases were assessed at baseline, 6 weeks and 6 months. ANCOVAs adjusted for baseline scores were used to assess differences between groups regarding outcome variables. Both per-protocol and intention-to-treat analyses were conducted.RESULTS: At 6 weeks, there was a significant difference in favor of MCT+ regarding decrease in delusion severity and improvement of self-reflectiveness (medium effect size), and a trend-wise difference regarding probability thresholds to decision. These effects increased, when only patients attending a minimum of 4 therapy sessions were considered. Control group patients subsequently showed further improvement while patients in the MCT+ group remained stable, such that there were no differences between groups at the 6-month follow-up.LIMITATIONS: Lower attendance rates in the control group possibly leading to unequal therapeutic effort; lower baseline delusion severity in the MCT+ group.CONCLUSIONS: The result pattern suggests that MCT+ led to earlier improvement in delusions and cognitive biases compared to the control intervention. The absence of a long-term effect might reflect floor effects in the MCT+ group, but may also indicate the need for further measures to promote sustainability of MCT+ effects.

KW - Journal Article

U2 - 10.1016/j.jbtep.2016.11.013

DO - 10.1016/j.jbtep.2016.11.013

M3 - SCORING: Journal article

C2 - 27919404

VL - 56

SP - 144

EP - 151

JO - J BEHAV THER EXP PSY

JF - J BEHAV THER EXP PSY

SN - 0005-7916

IS - SI

ER -