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Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition

Standard

Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition. / Lindner, T; Guerreiro, H; Austein, F; Fiehler, J.

In: EUR RADIOL, Vol. 32, No. 7, 07.2022, p. 4521-4526.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Lindner, T, Guerreiro, H, Austein, F & Fiehler, J 2022, 'Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition', EUR RADIOL, vol. 32, no. 7, pp. 4521-4526. https://doi.org/10.1007/s00330-022-08550-8

APA

Lindner, T., Guerreiro, H., Austein, F., & Fiehler, J. (2022). Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition. EUR RADIOL, 32(7), 4521-4526. https://doi.org/10.1007/s00330-022-08550-8

Vancouver

Lindner T, Guerreiro H, Austein F, Fiehler J. Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition. EUR RADIOL. 2022 Jul;32(7):4521-4526. https://doi.org/10.1007/s00330-022-08550-8

Bibtex

@article{e1bc303363994b1a86e0762ca6c90159,
title = "Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition",
abstract = "OBJECTIVE: Arterial spin labeling blood perfusion signal relies on the difference between a label and a control image. Background suppression pulses are commonly used to improve the contrast, yet these are based on estimates of tissue relaxation times. The aim of this study is to improve the perfusion contrast by individualizing the timing of these background suppression pulses by means of T1 mapping.METHODS: The optimized timing of the background suppression pulses is obtained by rapid T1 mapping employing the variable flip angle technique. Ten healthy volunteers were included in this study. To compare the results, visual grading and the Wilcoxon signed-rank test was used comparing three categories of image quality.RESULTS: The readers confirmed that the images of the proposed method generally show a higher signal-to-background ratio and cortical structures are better visible. Noise was mostly comparable to the standard method. Relative blood flow was statistically significant higher in the modified method.CONCLUSION: The individually optimized background suppression pulses improve the image appearance and allow for a better visualization of cortical structures. The proposed technique however prolongs scan time, which can be seen as negative result, yet needs to be further evaluated.KEY POINTS: • Background suppression timing in ASL can vary. • Both the label and control condition can be modified for T1 mapping. • Adapting the pulse timing improves the signal-to-background ratio.",
keywords = "Algorithms, Arteries, Brain/diagnostic imaging, Cerebrovascular Circulation/physiology, Humans, Image Processing, Computer-Assisted/methods, Magnetic Resonance Imaging/methods, Perfusion, Signal-To-Noise Ratio, Spin Labels",
author = "T Lindner and H Guerreiro and F Austein and J Fiehler",
note = "{\textcopyright} 2022. The Author(s).",
year = "2022",
month = jul,
doi = "10.1007/s00330-022-08550-8",
language = "English",
volume = "32",
pages = "4521--4526",
journal = "EUR RADIOL",
issn = "0938-7994",
publisher = "Springer",
number = "7",

}

RIS

TY - JOUR

T1 - Individualized arterial spin labeling background suppression by rapid T1 mapping during acquisition

AU - Lindner, T

AU - Guerreiro, H

AU - Austein, F

AU - Fiehler, J

N1 - © 2022. The Author(s).

PY - 2022/7

Y1 - 2022/7

N2 - OBJECTIVE: Arterial spin labeling blood perfusion signal relies on the difference between a label and a control image. Background suppression pulses are commonly used to improve the contrast, yet these are based on estimates of tissue relaxation times. The aim of this study is to improve the perfusion contrast by individualizing the timing of these background suppression pulses by means of T1 mapping.METHODS: The optimized timing of the background suppression pulses is obtained by rapid T1 mapping employing the variable flip angle technique. Ten healthy volunteers were included in this study. To compare the results, visual grading and the Wilcoxon signed-rank test was used comparing three categories of image quality.RESULTS: The readers confirmed that the images of the proposed method generally show a higher signal-to-background ratio and cortical structures are better visible. Noise was mostly comparable to the standard method. Relative blood flow was statistically significant higher in the modified method.CONCLUSION: The individually optimized background suppression pulses improve the image appearance and allow for a better visualization of cortical structures. The proposed technique however prolongs scan time, which can be seen as negative result, yet needs to be further evaluated.KEY POINTS: • Background suppression timing in ASL can vary. • Both the label and control condition can be modified for T1 mapping. • Adapting the pulse timing improves the signal-to-background ratio.

AB - OBJECTIVE: Arterial spin labeling blood perfusion signal relies on the difference between a label and a control image. Background suppression pulses are commonly used to improve the contrast, yet these are based on estimates of tissue relaxation times. The aim of this study is to improve the perfusion contrast by individualizing the timing of these background suppression pulses by means of T1 mapping.METHODS: The optimized timing of the background suppression pulses is obtained by rapid T1 mapping employing the variable flip angle technique. Ten healthy volunteers were included in this study. To compare the results, visual grading and the Wilcoxon signed-rank test was used comparing three categories of image quality.RESULTS: The readers confirmed that the images of the proposed method generally show a higher signal-to-background ratio and cortical structures are better visible. Noise was mostly comparable to the standard method. Relative blood flow was statistically significant higher in the modified method.CONCLUSION: The individually optimized background suppression pulses improve the image appearance and allow for a better visualization of cortical structures. The proposed technique however prolongs scan time, which can be seen as negative result, yet needs to be further evaluated.KEY POINTS: • Background suppression timing in ASL can vary. • Both the label and control condition can be modified for T1 mapping. • Adapting the pulse timing improves the signal-to-background ratio.

KW - Algorithms

KW - Arteries

KW - Brain/diagnostic imaging

KW - Cerebrovascular Circulation/physiology

KW - Humans

KW - Image Processing, Computer-Assisted/methods

KW - Magnetic Resonance Imaging/methods

KW - Perfusion

KW - Signal-To-Noise Ratio

KW - Spin Labels

U2 - 10.1007/s00330-022-08550-8

DO - 10.1007/s00330-022-08550-8

M3 - SCORING: Journal article

C2 - 35118530

VL - 32

SP - 4521

EP - 4526

JO - EUR RADIOL

JF - EUR RADIOL

SN - 0938-7994

IS - 7

ER -