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Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

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Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. / Andreassen, Christian Nicolaj; Rosenstein, Barry S; Kerns, Sarah L; Ostrer, Harry; De Ruysscher, Dirk; Cesaretti, Jamie A; Barnett, Gillian C; Dunning, Alison M; Dorling, Leila; West, Catharine M L; Burnet, Neil G; Elliott, Rebecca; Coles, Charlotte; Hall, Emma; Fachal, Laura; Vega, Ana; Gómez-Caamaño, Antonio; Talbot, Christopher J; Symonds, R Paul; De Ruyck, Kim; Thierens, Hubert; Ost, Piet; Chang-Claude, Jenny; Seibold, Petra; Popanda, Odilia; Overgaard, Marie; Dearnaley, David; Sydes, Matthew R; Azria, David; Koch, Christine Anne; Parliament, Matthew; Blackshaw, Michael; Sia, Michael; Fuentes-Raspall, Maria J; Ramon Y Cajal, Teresa; Barnadas, Agustin; Vesprini, Danny; Gutiérrez-Enríquez, Sara; Mollà, Meritxell; Díez, Orland; Yarnold, John R; Overgaard, Jens; Bentzen, Søren M; Alsner, Jan; International Radiogenomics Consortium (RgC).

In: RADIOTHER ONCOL, Vol. 121, No. 3, 12.2016, p. 431–439.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Andreassen, CN, Rosenstein, BS, Kerns, SL, Ostrer, H, De Ruysscher, D, Cesaretti, JA, Barnett, GC, Dunning, AM, Dorling, L, West, CML, Burnet, NG, Elliott, R, Coles, C, Hall, E, Fachal, L, Vega, A, Gómez-Caamaño, A, Talbot, CJ, Symonds, RP, De Ruyck, K, Thierens, H, Ost, P, Chang-Claude, J, Seibold, P, Popanda, O, Overgaard, M, Dearnaley, D, Sydes, MR, Azria, D, Koch, CA, Parliament, M, Blackshaw, M, Sia, M, Fuentes-Raspall, MJ, Ramon Y Cajal, T, Barnadas, A, Vesprini, D, Gutiérrez-Enríquez, S, Mollà, M, Díez, O, Yarnold, JR, Overgaard, J, Bentzen, SM, Alsner, J & International Radiogenomics Consortium (RgC) 2016, 'Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients', RADIOTHER ONCOL, vol. 121, no. 3, pp. 431–439. https://doi.org/10.1016/j.radonc.2016.06.017

APA

Andreassen, C. N., Rosenstein, B. S., Kerns, S. L., Ostrer, H., De Ruysscher, D., Cesaretti, J. A., Barnett, G. C., Dunning, A. M., Dorling, L., West, C. M. L., Burnet, N. G., Elliott, R., Coles, C., Hall, E., Fachal, L., Vega, A., Gómez-Caamaño, A., Talbot, C. J., Symonds, R. P., ... International Radiogenomics Consortium (RgC) (2016). Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. RADIOTHER ONCOL, 121(3), 431–439. https://doi.org/10.1016/j.radonc.2016.06.017

Vancouver

Andreassen CN, Rosenstein BS, Kerns SL, Ostrer H, De Ruysscher D, Cesaretti JA et al. Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients. RADIOTHER ONCOL. 2016 Dec;121(3):431–439. https://doi.org/10.1016/j.radonc.2016.06.017

Bibtex

@article{7ac8680970814d9cbd6671c3e5caed6d,
title = "Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients",
abstract = "PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.MATERIALS AND METHODS: The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity.RESULTS: For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance.CONCLUSION: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.",
author = "Andreassen, {Christian Nicolaj} and Rosenstein, {Barry S} and Kerns, {Sarah L} and Harry Ostrer and {De Ruysscher}, Dirk and Cesaretti, {Jamie A} and Barnett, {Gillian C} and Dunning, {Alison M} and Leila Dorling and West, {Catharine M L} and Burnet, {Neil G} and Rebecca Elliott and Charlotte Coles and Emma Hall and Laura Fachal and Ana Vega and Antonio G{\'o}mez-Caama{\~n}o and Talbot, {Christopher J} and Symonds, {R Paul} and {De Ruyck}, Kim and Hubert Thierens and Piet Ost and Jenny Chang-Claude and Petra Seibold and Odilia Popanda and Marie Overgaard and David Dearnaley and Sydes, {Matthew R} and David Azria and Koch, {Christine Anne} and Matthew Parliament and Michael Blackshaw and Michael Sia and Fuentes-Raspall, {Maria J} and {Ramon Y Cajal}, Teresa and Agustin Barnadas and Danny Vesprini and Sara Guti{\'e}rrez-Enr{\'i}quez and Meritxell Moll{\`a} and Orland D{\'i}ez and Yarnold, {John R} and Jens Overgaard and Bentzen, {S{\o}ren M} and Jan Alsner and {International Radiogenomics Consortium (RgC)}",
note = "Copyright {\textcopyright} 2016 Elsevier Ireland Ltd. All rights reserved.",
year = "2016",
month = dec,
doi = "10.1016/j.radonc.2016.06.017",
language = "English",
volume = "121",
pages = "431–439",
journal = "RADIOTHER ONCOL",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer patients

AU - Andreassen, Christian Nicolaj

AU - Rosenstein, Barry S

AU - Kerns, Sarah L

AU - Ostrer, Harry

AU - De Ruysscher, Dirk

AU - Cesaretti, Jamie A

AU - Barnett, Gillian C

AU - Dunning, Alison M

AU - Dorling, Leila

AU - West, Catharine M L

AU - Burnet, Neil G

AU - Elliott, Rebecca

AU - Coles, Charlotte

AU - Hall, Emma

AU - Fachal, Laura

AU - Vega, Ana

AU - Gómez-Caamaño, Antonio

AU - Talbot, Christopher J

AU - Symonds, R Paul

AU - De Ruyck, Kim

AU - Thierens, Hubert

AU - Ost, Piet

AU - Chang-Claude, Jenny

AU - Seibold, Petra

AU - Popanda, Odilia

AU - Overgaard, Marie

AU - Dearnaley, David

AU - Sydes, Matthew R

AU - Azria, David

AU - Koch, Christine Anne

AU - Parliament, Matthew

AU - Blackshaw, Michael

AU - Sia, Michael

AU - Fuentes-Raspall, Maria J

AU - Ramon Y Cajal, Teresa

AU - Barnadas, Agustin

AU - Vesprini, Danny

AU - Gutiérrez-Enríquez, Sara

AU - Mollà, Meritxell

AU - Díez, Orland

AU - Yarnold, John R

AU - Overgaard, Jens

AU - Bentzen, Søren M

AU - Alsner, Jan

AU - International Radiogenomics Consortium (RgC)

N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/12

Y1 - 2016/12

N2 - PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.MATERIALS AND METHODS: The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity.RESULTS: For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance.CONCLUSION: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

AB - PURPOSE: Several small studies have indicated that the ATM rs1801516 SNP is associated with risk of normal tissue toxicity after radiotherapy. However, the findings have not been consistent. In order to test this SNP in a well-powered study, an individual patient data meta-analysis was carried out by the International Radiogenomics Consortium.MATERIALS AND METHODS: The analysis included 5456 patients from 17 different cohorts. 2759 patients were given radiotherapy for breast cancer and 2697 for prostate cancer. Eight toxicity scores (overall toxicity, acute toxicity, late toxicity, acute skin toxicity, acute rectal toxicity, telangiectasia, fibrosis and late rectal toxicity) were analyzed. Adjustments were made for treatment and patient related factors with potential impact on the risk of toxicity.RESULTS: For all endpoints except late rectal toxicity, a significantly increased risk of toxicity was found for carriers of the minor (Asn) allele with odds of approximately 1.5 for acute toxicity and 1.2 for late toxicity. The results were consistent with a co-dominant pattern of inheritance.CONCLUSION: This study convincingly showed a significant association between the ATM rs1801516 Asn allele and increased risk of radiation-induced normal tissue toxicity.

U2 - 10.1016/j.radonc.2016.06.017

DO - 10.1016/j.radonc.2016.06.017

M3 - SCORING: Journal article

C2 - 27443449

VL - 121

SP - 431

EP - 439

JO - RADIOTHER ONCOL

JF - RADIOTHER ONCOL

SN - 0167-8140

IS - 3

ER -