[Indications and implementation of recommendations of the working group "Tissue Regeneration and Tissue Substitutes" for autologous chondrocyte transplantation (ACT)].
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[Indications and implementation of recommendations of the working group "Tissue Regeneration and Tissue Substitutes" for autologous chondrocyte transplantation (ACT)]. / Behrens, P; Bosch, U; Bruns, J; Erggelet, C; Esenwein, S A; Gaissmaier, C; Krackhardt, T; Löhnert, J; Marlovits, S; Meenen, Norbert; Mollenhauer, J; Nehrer, S; Niethard, F U; Nöth, U; Perka, C; Richter, W; Schäfer, D; Schneider, U; Steinwachs, M; Weise, K; Traumatology, German Society For; Surgery, German Society For Orthopedic.
In: Z ORTHOP GRENZGEB, Vol. 142, No. 5, 5, 2004, p. 529-539.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - [Indications and implementation of recommendations of the working group "Tissue Regeneration and Tissue Substitutes" for autologous chondrocyte transplantation (ACT)].
AU - Behrens, P
AU - Bosch, U
AU - Bruns, J
AU - Erggelet, C
AU - Esenwein, S A
AU - Gaissmaier, C
AU - Krackhardt, T
AU - Löhnert, J
AU - Marlovits, S
AU - Meenen, Norbert
AU - Mollenhauer, J
AU - Nehrer, S
AU - Niethard, F U
AU - Nöth, U
AU - Perka, C
AU - Richter, W
AU - Schäfer, D
AU - Schneider, U
AU - Steinwachs, M
AU - Weise, K
AU - Traumatology, German Society For
AU - Surgery, German Society For Orthopedic
N1 - Meenen: Orthopädische Universität der RWTH-Aachen
PY - 2004
Y1 - 2004
N2 - For the treatment of full-thickness articular cartilage lesions of the knee joint, as a result of trauma or osteochondritis dissecans, a variety of biological reconstruction techniques have been developed. Different studies, some of which were performed as randomised, prospective clinical studies, showed that the autologous chondrocyte transplantation (ACT) provides the most satisfying and reliable method of cartilage reconstruction in the adult when applied to defects exceeding 4 cm (2). Based on these results, ACT seems to be of economic benefit, as the risk of developing osteoarthritis correlates significantly with the size of the cartilage defect, when not treated properly and in time. Surveying the studies on basic scientific aspects of ACT, cartilage defect animal models and clinical studies, it can be concluded that clinical results of ACT depend on a variety of factors. In this review, published by the joined advisory board of the German Societies of Traumatology (DGU) and Orthopaedic Surgery (DGOOC), we summarize the current knowledge available and the state of the art concerning ACT. Especially we discuss the advantages of different procedures, methods for treating knee cartilage defects and factors that influence the outcome of the different treatment regimens, with the aim to develop guidelines for the correct indication and application of the ACT.
AB - For the treatment of full-thickness articular cartilage lesions of the knee joint, as a result of trauma or osteochondritis dissecans, a variety of biological reconstruction techniques have been developed. Different studies, some of which were performed as randomised, prospective clinical studies, showed that the autologous chondrocyte transplantation (ACT) provides the most satisfying and reliable method of cartilage reconstruction in the adult when applied to defects exceeding 4 cm (2). Based on these results, ACT seems to be of economic benefit, as the risk of developing osteoarthritis correlates significantly with the size of the cartilage defect, when not treated properly and in time. Surveying the studies on basic scientific aspects of ACT, cartilage defect animal models and clinical studies, it can be concluded that clinical results of ACT depend on a variety of factors. In this review, published by the joined advisory board of the German Societies of Traumatology (DGU) and Orthopaedic Surgery (DGOOC), we summarize the current knowledge available and the state of the art concerning ACT. Especially we discuss the advantages of different procedures, methods for treating knee cartilage defects and factors that influence the outcome of the different treatment regimens, with the aim to develop guidelines for the correct indication and application of the ACT.
KW - Adult
KW - Germany
KW - Humans
KW - Practice Guidelines as Topic
KW - Chondrocytes/transplantation
KW - Cartilage Diseases/surgery
KW - Physician's Practice Patterns/standards
KW - Tissue Engineering/methods/standards
KW - Transplantation, Autologous/methods/standards
KW - Transplants/standards
KW - Adult
KW - Germany
KW - Humans
KW - Practice Guidelines as Topic
KW - Chondrocytes/transplantation
KW - Cartilage Diseases/surgery
KW - Physician's Practice Patterns/standards
KW - Tissue Engineering/methods/standards
KW - Transplantation, Autologous/methods/standards
KW - Transplants/standards
M3 - SCORING: Zeitschriftenaufsatz
VL - 142
SP - 529
EP - 539
JO - Z ORTHOP GRENZGEB
JF - Z ORTHOP GRENZGEB
SN - 0044-3220
IS - 5
M1 - 5
ER -
