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Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients

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Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients. / Salomon, Georg; Drews, Nils; Autier, Philippe; Beckmann, Ann; Heinzer, Hans; Hansen, Jens; Michl, Uwe; Schlomm, Thorsten; Haese, Alex; Steuber, Thomas; Graefen, Markus; Becker, Andreas.

In: BJU INT, Vol. 113, No. 4, 01.04.2014, p. 548-553.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Salomon, G, Drews, N, Autier, P, Beckmann, A, Heinzer, H, Hansen, J, Michl, U, Schlomm, T, Haese, A, Steuber, T, Graefen, M & Becker, A 2014, 'Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients', BJU INT, vol. 113, no. 4, pp. 548-553. https://doi.org/10.1111/bju.12517

APA

Salomon, G., Drews, N., Autier, P., Beckmann, A., Heinzer, H., Hansen, J., Michl, U., Schlomm, T., Haese, A., Steuber, T., Graefen, M., & Becker, A. (2014). Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients. BJU INT, 113(4), 548-553. https://doi.org/10.1111/bju.12517

Vancouver

Salomon G, Drews N, Autier P, Beckmann A, Heinzer H, Hansen J et al. Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients. BJU INT. 2014 Apr 1;113(4):548-553. https://doi.org/10.1111/bju.12517

Bibtex

@article{c6305a7b7b474210aa5632f9eb2f4cd8,
title = "Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients",
abstract = "OBJECTIVE: To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy.PATIENTS AND METHODS: This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core transrectal ultrasonography (TRUS)-guided biopsy in a primary or rebiopsy setting. The overall DR, the DR of a 10-core randomized, RTE targeted biopsy and the incremental DR were calculated.RESULTS: Overall, randomized and RTE targeted biopsy DRs (for the combination, the 10-core and the four-core RTE biopsy scheme) were 46.2% (n = 473), 39.1% (n = 400) and 29.0% (n = 297), respectively. Four-core RTE targeted biopsies detected an additional 73 patients not detected by the 10-core randomized biopsies (increase in the overall DR of 7.1%). This represented a relative increase in DR of 18.3%. The incremental DR was better in rebiopsy patients (24.8%) than in patients having their first biopsy (14.7%). Within all patients diagnosed by RTE targeted biopsy only, 34 patients harboured significant Gleason 4 or 5 prostate cancer (PCa), diagnosed by four-core RTE biopsy only. Moreover, PCa with a Gleason grade of 4 or 5 was detected by four-core RTE biopsies in 30 patients, who showed low-grade PCa ≤ Gleason 3 only in the systematic 10-core biopsy.CONCLUSIONS: Real-time elastography targeted biopsy seems to be an appropriate method for increasing the DR of PCa. Nevertheless, RTE targeted biopsies missed a high proportion of patients with PCa and should therefore be considered as an addition to randomized biopsies.",
keywords = "Biopsy, Large-Core Needle, Elasticity Imaging Techniques, Humans, Male, Prostate-Specific Antigen, Prostatic Neoplasms, Random Allocation, Retreatment, Retrospective Studies",
author = "Georg Salomon and Nils Drews and Philippe Autier and Ann Beckmann and Hans Heinzer and Jens Hansen and Uwe Michl and Thorsten Schlomm and Alex Haese and Thomas Steuber and Markus Graefen and Andreas Becker",
note = "{\textcopyright} 2013 The Authors. BJU International {\textcopyright} 2013 BJU International.",
year = "2014",
month = apr,
day = "1",
doi = "10.1111/bju.12517",
language = "English",
volume = "113",
pages = "548--553",
journal = "BJU INT",
issn = "1464-4096",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients

AU - Salomon, Georg

AU - Drews, Nils

AU - Autier, Philippe

AU - Beckmann, Ann

AU - Heinzer, Hans

AU - Hansen, Jens

AU - Michl, Uwe

AU - Schlomm, Thorsten

AU - Haese, Alex

AU - Steuber, Thomas

AU - Graefen, Markus

AU - Becker, Andreas

N1 - © 2013 The Authors. BJU International © 2013 BJU International.

PY - 2014/4/1

Y1 - 2014/4/1

N2 - OBJECTIVE: To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy.PATIENTS AND METHODS: This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core transrectal ultrasonography (TRUS)-guided biopsy in a primary or rebiopsy setting. The overall DR, the DR of a 10-core randomized, RTE targeted biopsy and the incremental DR were calculated.RESULTS: Overall, randomized and RTE targeted biopsy DRs (for the combination, the 10-core and the four-core RTE biopsy scheme) were 46.2% (n = 473), 39.1% (n = 400) and 29.0% (n = 297), respectively. Four-core RTE targeted biopsies detected an additional 73 patients not detected by the 10-core randomized biopsies (increase in the overall DR of 7.1%). This represented a relative increase in DR of 18.3%. The incremental DR was better in rebiopsy patients (24.8%) than in patients having their first biopsy (14.7%). Within all patients diagnosed by RTE targeted biopsy only, 34 patients harboured significant Gleason 4 or 5 prostate cancer (PCa), diagnosed by four-core RTE biopsy only. Moreover, PCa with a Gleason grade of 4 or 5 was detected by four-core RTE biopsies in 30 patients, who showed low-grade PCa ≤ Gleason 3 only in the systematic 10-core biopsy.CONCLUSIONS: Real-time elastography targeted biopsy seems to be an appropriate method for increasing the DR of PCa. Nevertheless, RTE targeted biopsies missed a high proportion of patients with PCa and should therefore be considered as an addition to randomized biopsies.

AB - OBJECTIVE: To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy.PATIENTS AND METHODS: This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core transrectal ultrasonography (TRUS)-guided biopsy in a primary or rebiopsy setting. The overall DR, the DR of a 10-core randomized, RTE targeted biopsy and the incremental DR were calculated.RESULTS: Overall, randomized and RTE targeted biopsy DRs (for the combination, the 10-core and the four-core RTE biopsy scheme) were 46.2% (n = 473), 39.1% (n = 400) and 29.0% (n = 297), respectively. Four-core RTE targeted biopsies detected an additional 73 patients not detected by the 10-core randomized biopsies (increase in the overall DR of 7.1%). This represented a relative increase in DR of 18.3%. The incremental DR was better in rebiopsy patients (24.8%) than in patients having their first biopsy (14.7%). Within all patients diagnosed by RTE targeted biopsy only, 34 patients harboured significant Gleason 4 or 5 prostate cancer (PCa), diagnosed by four-core RTE biopsy only. Moreover, PCa with a Gleason grade of 4 or 5 was detected by four-core RTE biopsies in 30 patients, who showed low-grade PCa ≤ Gleason 3 only in the systematic 10-core biopsy.CONCLUSIONS: Real-time elastography targeted biopsy seems to be an appropriate method for increasing the DR of PCa. Nevertheless, RTE targeted biopsies missed a high proportion of patients with PCa and should therefore be considered as an addition to randomized biopsies.

KW - Biopsy, Large-Core Needle

KW - Elasticity Imaging Techniques

KW - Humans

KW - Male

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - Random Allocation

KW - Retreatment

KW - Retrospective Studies

U2 - 10.1111/bju.12517

DO - 10.1111/bju.12517

M3 - SCORING: Journal article

C2 - 24128330

VL - 113

SP - 548

EP - 553

JO - BJU INT

JF - BJU INT

SN - 1464-4096

IS - 4

ER -