Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis
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Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis : A Matter of Inflammation. / Moritz, Eileen; Jedlitschky, Gabriele; Negnal, Josefine; Tzvetkov, Mladen V; Daum, Günter; Dörr, Marcus; Felix, Stephan B; Völzke, Henry; Nauck, Matthias; Schwedhelm, Edzard; Meisel, Peter; Kocher, Thomas; Rauch, Bernhard H; Holtfreter, Birte.
In: J INFLAMM RES, Vol. 14, 2021, p. 2883-2896.Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review
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TY - JOUR
T1 - Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis
T2 - A Matter of Inflammation
AU - Moritz, Eileen
AU - Jedlitschky, Gabriele
AU - Negnal, Josefine
AU - Tzvetkov, Mladen V
AU - Daum, Günter
AU - Dörr, Marcus
AU - Felix, Stephan B
AU - Völzke, Henry
AU - Nauck, Matthias
AU - Schwedhelm, Edzard
AU - Meisel, Peter
AU - Kocher, Thomas
AU - Rauch, Bernhard H
AU - Holtfreter, Birte
N1 - © 2021 Moritz et al.
PY - 2021
Y1 - 2021
N2 - Purpose: Periodontitis is an inflammatory disease of the oral cavity with an alarmingly high prevalence within the adult population. The signaling lipid sphingosine-1-phosphate (S1P) plays a crucial role in inflammatory and immunomodulatory responses. In addition to cardiovascular disease, sepsis and tumor entities, S1P has been recently identified as both mediator and biomarker in osteoporosis. We hypothesized that S1P may play a role in periodontitis as an inflammation-prone bone destructive disorder. The goal of our study was to evaluate associations between periodontitis and S1P serum concentrations in the Study of Health in Pomerania (SHIP)-Trend cohort. In addition, we investigated the expression of S1P metabolizing enzymes in inflamed gingival tissue.Patients and Methods: We analyzed data from 3371 participants (51.6% women) of the SHIP-Trend cohort. Periodontal parameters and baseline characteristics were assessed. Serum S1P was measured by liquid chromatography tandem mass spectrometry. The expression of S1P metabolizing enzymes was determined by immunofluorescence staining of human gingival tissue.Results: S1P serum concentrations were significantly increased in subjects with both moderate and severe periodontitis, assessed as probing depth and clinical attachment loss. In contrast, no significant association of S1P was seen with caries variables (number and percentage of decayed or filled surfaces). S1P concentrations significantly increased with increasing high-sensitivity C-reactive protein (hs-CRP) levels. Interestingly, inflamed compared to normal human gingival tissue exhibited elevated expression levels of the S1P-generating enzyme sphingosine kinase 1 (SphK1).Conclusion: We report an intriguingly significant association of various periodontal parameters with serum levels of the inflammatory lipid mediator S1P. Our data point towards a key role of S1P during periodontitis pathology. Modulation of local S1P levels or its signaling properties may represent a potential future therapeutic strategy to prevent or to retard periodontitis progression and possibly reduce periodontitis-related tooth loss.
AB - Purpose: Periodontitis is an inflammatory disease of the oral cavity with an alarmingly high prevalence within the adult population. The signaling lipid sphingosine-1-phosphate (S1P) plays a crucial role in inflammatory and immunomodulatory responses. In addition to cardiovascular disease, sepsis and tumor entities, S1P has been recently identified as both mediator and biomarker in osteoporosis. We hypothesized that S1P may play a role in periodontitis as an inflammation-prone bone destructive disorder. The goal of our study was to evaluate associations between periodontitis and S1P serum concentrations in the Study of Health in Pomerania (SHIP)-Trend cohort. In addition, we investigated the expression of S1P metabolizing enzymes in inflamed gingival tissue.Patients and Methods: We analyzed data from 3371 participants (51.6% women) of the SHIP-Trend cohort. Periodontal parameters and baseline characteristics were assessed. Serum S1P was measured by liquid chromatography tandem mass spectrometry. The expression of S1P metabolizing enzymes was determined by immunofluorescence staining of human gingival tissue.Results: S1P serum concentrations were significantly increased in subjects with both moderate and severe periodontitis, assessed as probing depth and clinical attachment loss. In contrast, no significant association of S1P was seen with caries variables (number and percentage of decayed or filled surfaces). S1P concentrations significantly increased with increasing high-sensitivity C-reactive protein (hs-CRP) levels. Interestingly, inflamed compared to normal human gingival tissue exhibited elevated expression levels of the S1P-generating enzyme sphingosine kinase 1 (SphK1).Conclusion: We report an intriguingly significant association of various periodontal parameters with serum levels of the inflammatory lipid mediator S1P. Our data point towards a key role of S1P during periodontitis pathology. Modulation of local S1P levels or its signaling properties may represent a potential future therapeutic strategy to prevent or to retard periodontitis progression and possibly reduce periodontitis-related tooth loss.
U2 - 10.2147/JIR.S302117
DO - 10.2147/JIR.S302117
M3 - SCORING: Journal article
C2 - 34234513
VL - 14
SP - 2883
EP - 2896
JO - J INFLAMM RES
JF - J INFLAMM RES
SN - 1178-7031
ER -
