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Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy

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Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy. / Eichhorn, Wolfgang; Haase, Martina; Kluwe, Lan; Zeuch, Jürgen; Smeets, Ralf; Hanken, Henning; Wehrmann, Manfred; Gröbe, Alexander; Heiland, Max; Birkelbach, Moritz; Rendenbach, Carsten.

In: BIOMED RES INT , Vol. 2015, 06.08.2015, p. 120903.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Eichhorn, W, Haase, M, Kluwe, L, Zeuch, J, Smeets, R, Hanken, H, Wehrmann, M, Gröbe, A, Heiland, M, Birkelbach, M & Rendenbach, C 2015, 'Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy', BIOMED RES INT , vol. 2015, pp. 120903. https://doi.org/10.1155/2015/120903

APA

Eichhorn, W., Haase, M., Kluwe, L., Zeuch, J., Smeets, R., Hanken, H., Wehrmann, M., Gröbe, A., Heiland, M., Birkelbach, M., & Rendenbach, C. (2015). Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy. BIOMED RES INT , 2015, 120903. https://doi.org/10.1155/2015/120903

Vancouver

Eichhorn W, Haase M, Kluwe L, Zeuch J, Smeets R, Hanken H et al. Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy. BIOMED RES INT . 2015 Aug 6;2015:120903. https://doi.org/10.1155/2015/120903

Bibtex

@article{6bf6d8677412487d875f4577fd98022c,
title = "Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy",
abstract = "Purpose. The purpose of the study was to evaluate the influence of a continued antiplatelet therapy with clopidogrel on postoperative bleeding risk in patients undergoing skin tumor resection and reconstruction with local flaps or skin grafts under outpatient conditions. Patients and Methods. The authors designed and implemented a retrospective clinical cohort study at the General Hospital Balingen. The primary endpoint was the bleeding ratio in patients with clopidogrel treatment in comparison to patients without any anticoagulant or antiplatelet therapy. Wound healing was evaluated on days 1, 3, 5, 7, 10, and 14. Results. 650 procedures were performed, 123 of them under continued clopidogrel therapy. There were significantly more postoperative bleeding complications among patients with continued antiplatelet therapy. Regarding the whole study population, malignant lesions, a larger defect size, and skin grafts were accompanied by a higher rate of bleeding incidents. However, there were no significant findings in the univariate analysis of the clopidogrel group. All bleeding incidents were easily manageable. Conclusion. Despite an increased bleeding ratio among patients under continued clopidogrel therapy, the performance of simple surgical procedures can be recommended. However, cautious preparation and careful hemostasis are indispensable.",
author = "Wolfgang Eichhorn and Martina Haase and Lan Kluwe and J{\"u}rgen Zeuch and Ralf Smeets and Henning Hanken and Manfred Wehrmann and Alexander Gr{\"o}be and Max Heiland and Moritz Birkelbach and Carsten Rendenbach",
year = "2015",
month = aug,
day = "6",
doi = "10.1155/2015/120903",
language = "English",
volume = "2015",
pages = "120903",
journal = "BIOMED RES INT ",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - Increased Postoperative Bleeding Risk among Patients with Local Flap Surgery under Continued Clopidogrel Therapy

AU - Eichhorn, Wolfgang

AU - Haase, Martina

AU - Kluwe, Lan

AU - Zeuch, Jürgen

AU - Smeets, Ralf

AU - Hanken, Henning

AU - Wehrmann, Manfred

AU - Gröbe, Alexander

AU - Heiland, Max

AU - Birkelbach, Moritz

AU - Rendenbach, Carsten

PY - 2015/8/6

Y1 - 2015/8/6

N2 - Purpose. The purpose of the study was to evaluate the influence of a continued antiplatelet therapy with clopidogrel on postoperative bleeding risk in patients undergoing skin tumor resection and reconstruction with local flaps or skin grafts under outpatient conditions. Patients and Methods. The authors designed and implemented a retrospective clinical cohort study at the General Hospital Balingen. The primary endpoint was the bleeding ratio in patients with clopidogrel treatment in comparison to patients without any anticoagulant or antiplatelet therapy. Wound healing was evaluated on days 1, 3, 5, 7, 10, and 14. Results. 650 procedures were performed, 123 of them under continued clopidogrel therapy. There were significantly more postoperative bleeding complications among patients with continued antiplatelet therapy. Regarding the whole study population, malignant lesions, a larger defect size, and skin grafts were accompanied by a higher rate of bleeding incidents. However, there were no significant findings in the univariate analysis of the clopidogrel group. All bleeding incidents were easily manageable. Conclusion. Despite an increased bleeding ratio among patients under continued clopidogrel therapy, the performance of simple surgical procedures can be recommended. However, cautious preparation and careful hemostasis are indispensable.

AB - Purpose. The purpose of the study was to evaluate the influence of a continued antiplatelet therapy with clopidogrel on postoperative bleeding risk in patients undergoing skin tumor resection and reconstruction with local flaps or skin grafts under outpatient conditions. Patients and Methods. The authors designed and implemented a retrospective clinical cohort study at the General Hospital Balingen. The primary endpoint was the bleeding ratio in patients with clopidogrel treatment in comparison to patients without any anticoagulant or antiplatelet therapy. Wound healing was evaluated on days 1, 3, 5, 7, 10, and 14. Results. 650 procedures were performed, 123 of them under continued clopidogrel therapy. There were significantly more postoperative bleeding complications among patients with continued antiplatelet therapy. Regarding the whole study population, malignant lesions, a larger defect size, and skin grafts were accompanied by a higher rate of bleeding incidents. However, there were no significant findings in the univariate analysis of the clopidogrel group. All bleeding incidents were easily manageable. Conclusion. Despite an increased bleeding ratio among patients under continued clopidogrel therapy, the performance of simple surgical procedures can be recommended. However, cautious preparation and careful hemostasis are indispensable.

U2 - 10.1155/2015/120903

DO - 10.1155/2015/120903

M3 - SCORING: Journal article

C2 - 26345612

VL - 2015

SP - 120903

JO - BIOMED RES INT

JF - BIOMED RES INT

SN - 2314-6133

ER -