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Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG)

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Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG). / Bartsch, S; Montag, D; Schachner, M; Bartsch, U.

In: BRAIN RES, Vol. 762, No. 1-2, 11.07.1997, p. 231-4.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bartsch, S, Montag, D, Schachner, M & Bartsch, U 1997, 'Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG)', BRAIN RES, vol. 762, no. 1-2, pp. 231-4.

APA

Bartsch, S., Montag, D., Schachner, M., & Bartsch, U. (1997). Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG). BRAIN RES, 762(1-2), 231-4.

Vancouver

Bartsch S, Montag D, Schachner M, Bartsch U. Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG). BRAIN RES. 1997 Jul 11;762(1-2):231-4.

Bibtex

@article{84347a7a9b2a42399900c2086f5303ba,
title = "Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG)",
abstract = "We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is detectable in adult MAG mutants. In optic nerves of 2- and 9-month-old MAG-deficient mice, we observed a significantly increased number of unmyelinated axons compared to age-matched wild-type mice. At both ages, unmyelinated axons in optic nerves of MAG mutants were of small caliber. The number of unmyelinated axons decreased significantly in 9-month-old MAG mutants when compared to 2-month-old MAG mutants, indicative of a slow and long-lasting myelination of axons in the mutant. Our observations support the view that MAG is involved in the initiation of myelination in the CNS.",
keywords = "Animals, Mice, Mice, Knockout, Microscopy, Electron, Myelin Sheath, Myelin-Associated Glycoprotein, Nerve Fibers, Myelinated, Oligodendroglia, Optic Nerve, Journal Article, Research Support, Non-U.S. Gov't",
author = "S Bartsch and D Montag and M Schachner and U Bartsch",
year = "1997",
month = jul,
day = "11",
language = "English",
volume = "762",
pages = "231--4",
journal = "BRAIN RES",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

RIS

TY - JOUR

T1 - Increased number of unmyelinated axons in optic nerves of adult mice deficient in the myelin-associated glycoprotein (MAG)

AU - Bartsch, S

AU - Montag, D

AU - Schachner, M

AU - Bartsch, U

PY - 1997/7/11

Y1 - 1997/7/11

N2 - We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is detectable in adult MAG mutants. In optic nerves of 2- and 9-month-old MAG-deficient mice, we observed a significantly increased number of unmyelinated axons compared to age-matched wild-type mice. At both ages, unmyelinated axons in optic nerves of MAG mutants were of small caliber. The number of unmyelinated axons decreased significantly in 9-month-old MAG mutants when compared to 2-month-old MAG mutants, indicative of a slow and long-lasting myelination of axons in the mutant. Our observations support the view that MAG is involved in the initiation of myelination in the CNS.

AB - We have recently demonstrated that the formation of myelin sheaths in the optic nerve of young postnatal mice deficient in the myelin-associated glycoprotein (MAG) is retarded when compared to age-matched wild-type mice. In the present study, we analyzed whether impaired myelination of retinal ganglion cell axons is detectable in adult MAG mutants. In optic nerves of 2- and 9-month-old MAG-deficient mice, we observed a significantly increased number of unmyelinated axons compared to age-matched wild-type mice. At both ages, unmyelinated axons in optic nerves of MAG mutants were of small caliber. The number of unmyelinated axons decreased significantly in 9-month-old MAG mutants when compared to 2-month-old MAG mutants, indicative of a slow and long-lasting myelination of axons in the mutant. Our observations support the view that MAG is involved in the initiation of myelination in the CNS.

KW - Animals

KW - Mice

KW - Mice, Knockout

KW - Microscopy, Electron

KW - Myelin Sheath

KW - Myelin-Associated Glycoprotein

KW - Nerve Fibers, Myelinated

KW - Oligodendroglia

KW - Optic Nerve

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

M3 - SCORING: Journal article

C2 - 9262180

VL - 762

SP - 231

EP - 234

JO - BRAIN RES

JF - BRAIN RES

SN - 0006-8993

IS - 1-2

ER -