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Increased Number of Mast Cells in Atherosclerotic Lesions Correlates with the Presence of Myeloid but not Plasmacytoid Dendritic Cells as well as Pro-inflammatory T Cells

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Increased Number of Mast Cells in Atherosclerotic Lesions Correlates with the Presence of Myeloid but not Plasmacytoid Dendritic Cells as well as Pro-inflammatory T Cells. / Rohm, Ilonka; Sattler, Sandra; Atiskova, Yevgeniya; Kretzschmar, Daniel; Pistulli, Rudin; Franz, Marcus; Jung, Christian; Mall, Gita; Kronert, Thomas; Schulze, Paul C; Yilmaz, Atilla.

In: CLIN LAB, Vol. 62, No. 12, 01.12.2016, p. 2293-2303.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Rohm, I, Sattler, S, Atiskova, Y, Kretzschmar, D, Pistulli, R, Franz, M, Jung, C, Mall, G, Kronert, T, Schulze, PC & Yilmaz, A 2016, 'Increased Number of Mast Cells in Atherosclerotic Lesions Correlates with the Presence of Myeloid but not Plasmacytoid Dendritic Cells as well as Pro-inflammatory T Cells', CLIN LAB, vol. 62, no. 12, pp. 2293-2303. https://doi.org/10.7754/Clin.Lab.2016.160517

APA

Rohm, I., Sattler, S., Atiskova, Y., Kretzschmar, D., Pistulli, R., Franz, M., Jung, C., Mall, G., Kronert, T., Schulze, P. C., & Yilmaz, A. (2016). Increased Number of Mast Cells in Atherosclerotic Lesions Correlates with the Presence of Myeloid but not Plasmacytoid Dendritic Cells as well as Pro-inflammatory T Cells. CLIN LAB, 62(12), 2293-2303. https://doi.org/10.7754/Clin.Lab.2016.160517

Vancouver

Rohm I, Sattler S, Atiskova Y, Kretzschmar D, Pistulli R, Franz M et al. Increased Number of Mast Cells in Atherosclerotic Lesions Correlates with the Presence of Myeloid but not Plasmacytoid Dendritic Cells as well as Pro-inflammatory T Cells. CLIN LAB. 2016 Dec 1;62(12):2293-2303. https://doi.org/10.7754/Clin.Lab.2016.160517

Bibtex

@article{f7a2f4a5b52f40f5b83780c0003b4bc4,
title = "Increased Number of Mast Cells in Atherosclerotic Lesions Correlates with the Presence of Myeloid but not Plasmacytoid Dendritic Cells as well as Pro-inflammatory T Cells",
abstract = "BACKGROUND: Atherosclerosis is an inflammatory disease of the vessel wall promoted by different immune cells and inflammatory mediators.METHODS: In this study, 26 human plaques and 12 control vessels without atherosclerosis were immunohistochemically stained to analyze the emergence of mast cells dependent on plaque morphology and to correlate mast cell occurrence with the emergence of myeloid as well as plasmacytoid dendritic cells. Also, mast cell emergence was correlated with the number of pro-inflammatory T cells. For this, plaques were classified as stable or unstable according to established histological criteria.RESULTS: As expected, atherosclerotic lesions showed significantly higher numbers of tryptase+, chymase+, and cathepsin G+ mast cells compared to control vessels, particularly in lesions with unstable morphology. As a novel finding, we detected significant correlations between mast cells and myeloid dendritic cells (fascin, CD83, r > 0.3, p < 0.01), but not plasmacytoid dendritic cells (CD123, CD304). Also, we observed significant correlations of mast cells and different subgroups of pro-inflammatory T cells (CD3, CD8, CD161, CD25; r > 0.35, p < 0.05).CONCLUSIONS: Overall, the higher number of mast cells in plaques, particularly with unstable morphology, suggests that mast cells might be involved in the progression of atherosclerosis. The correlation of mast cells with other immune cells that are pivotal in atherogenesis, e.g., myeloid dendritic cells and pro-inflammatory T cells, also suggests an interplay leading to plaque destabilization. Therefore, modulating local mast cell function and invasion into the plaque might be a therapeutic tool for plaque stabilization.",
keywords = "Aged, Biomarkers/analysis, Carotid Arteries/enzymology, Carotid Stenosis/enzymology, Case-Control Studies, Dendritic Cells/enzymology, Disease Progression, Female, Femoral Artery/enzymology, Humans, Inflammation/enzymology, Male, Mast Cells/enzymology, Middle Aged, Myeloid Cells/enzymology, Peripheral Arterial Disease/enzymology, Plaque, Atherosclerotic, Prognosis, Rupture, Spontaneous",
author = "Ilonka Rohm and Sandra Sattler and Yevgeniya Atiskova and Daniel Kretzschmar and Rudin Pistulli and Marcus Franz and Christian Jung and Gita Mall and Thomas Kronert and Schulze, {Paul C} and Atilla Yilmaz",
year = "2016",
month = dec,
day = "1",
doi = "10.7754/Clin.Lab.2016.160517",
language = "English",
volume = "62",
pages = "2293--2303",
journal = "CLIN LAB",
issn = "1433-6510",
publisher = "Verlag Klinisches Labor GmbH",
number = "12",

}

RIS

TY - JOUR

T1 - Increased Number of Mast Cells in Atherosclerotic Lesions Correlates with the Presence of Myeloid but not Plasmacytoid Dendritic Cells as well as Pro-inflammatory T Cells

AU - Rohm, Ilonka

AU - Sattler, Sandra

AU - Atiskova, Yevgeniya

AU - Kretzschmar, Daniel

AU - Pistulli, Rudin

AU - Franz, Marcus

AU - Jung, Christian

AU - Mall, Gita

AU - Kronert, Thomas

AU - Schulze, Paul C

AU - Yilmaz, Atilla

PY - 2016/12/1

Y1 - 2016/12/1

N2 - BACKGROUND: Atherosclerosis is an inflammatory disease of the vessel wall promoted by different immune cells and inflammatory mediators.METHODS: In this study, 26 human plaques and 12 control vessels without atherosclerosis were immunohistochemically stained to analyze the emergence of mast cells dependent on plaque morphology and to correlate mast cell occurrence with the emergence of myeloid as well as plasmacytoid dendritic cells. Also, mast cell emergence was correlated with the number of pro-inflammatory T cells. For this, plaques were classified as stable or unstable according to established histological criteria.RESULTS: As expected, atherosclerotic lesions showed significantly higher numbers of tryptase+, chymase+, and cathepsin G+ mast cells compared to control vessels, particularly in lesions with unstable morphology. As a novel finding, we detected significant correlations between mast cells and myeloid dendritic cells (fascin, CD83, r > 0.3, p < 0.01), but not plasmacytoid dendritic cells (CD123, CD304). Also, we observed significant correlations of mast cells and different subgroups of pro-inflammatory T cells (CD3, CD8, CD161, CD25; r > 0.35, p < 0.05).CONCLUSIONS: Overall, the higher number of mast cells in plaques, particularly with unstable morphology, suggests that mast cells might be involved in the progression of atherosclerosis. The correlation of mast cells with other immune cells that are pivotal in atherogenesis, e.g., myeloid dendritic cells and pro-inflammatory T cells, also suggests an interplay leading to plaque destabilization. Therefore, modulating local mast cell function and invasion into the plaque might be a therapeutic tool for plaque stabilization.

AB - BACKGROUND: Atherosclerosis is an inflammatory disease of the vessel wall promoted by different immune cells and inflammatory mediators.METHODS: In this study, 26 human plaques and 12 control vessels without atherosclerosis were immunohistochemically stained to analyze the emergence of mast cells dependent on plaque morphology and to correlate mast cell occurrence with the emergence of myeloid as well as plasmacytoid dendritic cells. Also, mast cell emergence was correlated with the number of pro-inflammatory T cells. For this, plaques were classified as stable or unstable according to established histological criteria.RESULTS: As expected, atherosclerotic lesions showed significantly higher numbers of tryptase+, chymase+, and cathepsin G+ mast cells compared to control vessels, particularly in lesions with unstable morphology. As a novel finding, we detected significant correlations between mast cells and myeloid dendritic cells (fascin, CD83, r > 0.3, p < 0.01), but not plasmacytoid dendritic cells (CD123, CD304). Also, we observed significant correlations of mast cells and different subgroups of pro-inflammatory T cells (CD3, CD8, CD161, CD25; r > 0.35, p < 0.05).CONCLUSIONS: Overall, the higher number of mast cells in plaques, particularly with unstable morphology, suggests that mast cells might be involved in the progression of atherosclerosis. The correlation of mast cells with other immune cells that are pivotal in atherogenesis, e.g., myeloid dendritic cells and pro-inflammatory T cells, also suggests an interplay leading to plaque destabilization. Therefore, modulating local mast cell function and invasion into the plaque might be a therapeutic tool for plaque stabilization.

KW - Aged

KW - Biomarkers/analysis

KW - Carotid Arteries/enzymology

KW - Carotid Stenosis/enzymology

KW - Case-Control Studies

KW - Dendritic Cells/enzymology

KW - Disease Progression

KW - Female

KW - Femoral Artery/enzymology

KW - Humans

KW - Inflammation/enzymology

KW - Male

KW - Mast Cells/enzymology

KW - Middle Aged

KW - Myeloid Cells/enzymology

KW - Peripheral Arterial Disease/enzymology

KW - Plaque, Atherosclerotic

KW - Prognosis

KW - Rupture, Spontaneous

U2 - 10.7754/Clin.Lab.2016.160517

DO - 10.7754/Clin.Lab.2016.160517

M3 - SCORING: Journal article

C2 - 28164558

VL - 62

SP - 2293

EP - 2303

JO - CLIN LAB

JF - CLIN LAB

SN - 1433-6510

IS - 12

ER -