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Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish

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Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish. / Suniaga, Santiago; Rolvien, Tim; Vom Scheidt, Annika; Fiedler, Imke A K; Bale, Hrishikesh A; Huysseune, Ann; Witten, P Eckhard; Amling, Michael; Busse, Björn.

In: SCI REP-UK, Vol. 8, No. 1, 26.02.2018, p. 3646.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Suniaga, S, Rolvien, T, Vom Scheidt, A, Fiedler, IAK, Bale, HA, Huysseune, A, Witten, PE, Amling, M & Busse, B 2018, 'Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish', SCI REP-UK, vol. 8, no. 1, pp. 3646. https://doi.org/10.1038/s41598-018-21776-1

APA

Suniaga, S., Rolvien, T., Vom Scheidt, A., Fiedler, I. A. K., Bale, H. A., Huysseune, A., Witten, P. E., Amling, M., & Busse, B. (2018). Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish. SCI REP-UK, 8(1), 3646. https://doi.org/10.1038/s41598-018-21776-1

Vancouver

Suniaga S, Rolvien T, Vom Scheidt A, Fiedler IAK, Bale HA, Huysseune A et al. Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish. SCI REP-UK. 2018 Feb 26;8(1):3646. https://doi.org/10.1038/s41598-018-21776-1

Bibtex

@article{2e988fd2df54426b81cc1ead518ded0b,
title = "Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish",
abstract = "Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age- and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, bone volume and mineralization. Clearly, modeling processes in zebrafish bone resemble processes in human bone. This study highlights how exercise experiments in adult zebrafish foster in-depth insight into aging-related bone diseases and can thus catalyze the search for appropriate prevention and new treatment options.",
keywords = "Journal Article",
author = "Santiago Suniaga and Tim Rolvien and {Vom Scheidt}, Annika and Fiedler, {Imke A K} and Bale, {Hrishikesh A} and Ann Huysseune and Witten, {P Eckhard} and Michael Amling and Bj{\"o}rn Busse",
year = "2018",
month = feb,
day = "26",
doi = "10.1038/s41598-018-21776-1",
language = "English",
volume = "8",
pages = "3646",
journal = "SCI REP-UK",
issn = "2045-2322",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Increased mechanical loading through controlled swimming exercise induces bone formation and mineralization in adult zebrafish

AU - Suniaga, Santiago

AU - Rolvien, Tim

AU - Vom Scheidt, Annika

AU - Fiedler, Imke A K

AU - Bale, Hrishikesh A

AU - Huysseune, Ann

AU - Witten, P Eckhard

AU - Amling, Michael

AU - Busse, Björn

PY - 2018/2/26

Y1 - 2018/2/26

N2 - Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age- and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, bone volume and mineralization. Clearly, modeling processes in zebrafish bone resemble processes in human bone. This study highlights how exercise experiments in adult zebrafish foster in-depth insight into aging-related bone diseases and can thus catalyze the search for appropriate prevention and new treatment options.

AB - Exercise promotes gain in bone mass through adaptive responses of the vertebrate skeleton. This mechanism counteracts age- and disease-related skeletal degradation, but remains to be fully understood. In life sciences, zebrafish emerged as a vertebrate model that can provide new insights into the complex mechanisms governing bone quality. To test the hypothesis that musculoskeletal exercise induces bone adaptation in adult zebrafish and to characterize bone reorganization, animals were subjected to increased physical exercise for four weeks in a swim tunnel experiment. Cellular, structural and compositional changes of loaded vertebrae were quantified using integrated high-resolution analyses. Exercise triggered rapid bone adaptation with substantial increases in bone-forming osteoblasts, bone volume and mineralization. Clearly, modeling processes in zebrafish bone resemble processes in human bone. This study highlights how exercise experiments in adult zebrafish foster in-depth insight into aging-related bone diseases and can thus catalyze the search for appropriate prevention and new treatment options.

KW - Journal Article

U2 - 10.1038/s41598-018-21776-1

DO - 10.1038/s41598-018-21776-1

M3 - SCORING: Journal article

C2 - 29483529

VL - 8

SP - 3646

JO - SCI REP-UK

JF - SCI REP-UK

SN - 2045-2322

IS - 1

ER -