Research ExplorerPublicationsIncreased lysophosphatidylcholine acyltransferase 1 expressi...

Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients

Standard

Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients. / Bellon, Eugen; Grupp, Katharina; Ghadban, Tarik; Tachezy, Michael; Bachmann, Kai; Izbicki, Jakob Robert; Simon, Ronald; Sauter, Guido; Hube-Magg, Claudia; Melling, Nathaniel.

In: J CANCER RES CLIN, Vol. 147, No. 10, 10.2021, p. 2879-2884.

Research output: SCORING: Contribution to journal › SCORING: Journal article › Research › peer-review

Harvard

Bellon, E, Grupp, K, Ghadban, T, Tachezy, M, Bachmann, K, Izbicki, JR, Simon, R, Sauter, G, Hube-Magg, C & Melling, N 2021, 'Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients', J CANCER RES CLIN, vol. 147, no. 10, pp. 2879-2884. https://doi.org/10.1007/s00432-021-03686-4

APA

Bellon, E., Grupp, K., Ghadban, T., Tachezy, M., Bachmann, K., Izbicki, J. R., Simon, R., Sauter, G., Hube-Magg, C., & Melling, N. (2021). Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients. J CANCER RES CLIN, 147(10), 2879-2884. https://doi.org/10.1007/s00432-021-03686-4

Vancouver

Bellon E, Grupp K, Ghadban T, Tachezy M, Bachmann K, Izbicki JR et al. Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients. J CANCER RES CLIN. 2021 Oct;147(10):2879-2884. https://doi.org/10.1007/s00432-021-03686-4

Bibtex

@article{dd09c3d18b084c72963e8936a5636443,
title = "Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients",
abstract = "INTRODUCTION: Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has repeatedly been suggested to be associated with tumorigenesis. To evaluate the role of LPCAT1 in esophageal cancer, LPCAT1 immunostaining was analyzed on a tissue microarray containing samples from esophageal cancer patients.RESULTS: In benign esophageal tissue, LPCAT1 staining was detectable in low intensities. LPCAT1 staining was increased in malignant as compared to benign esophageal tissue and was found in high intensity in 26.4% of 288 interpretable esophageal adenocarcinomas (EACs) and in 23.2% of 211 squamous cell carcinomas (ESCCs). Increased LPCAT1 staining was linked to undifferentiated tumor grading in both subtypes of EACs and ESCCs (p = 0.0273 and p = 0.0085).CONCLUSION: However, LPCAT1 was not associated with prognosis of EAC and ESCC patients (p = 0.6838 and p = 0.4695) and thus cannot be considered a prognostic biomarker in esophageal cancers.",
author = "Eugen Bellon and Katharina Grupp and Tarik Ghadban and Michael Tachezy and Kai Bachmann and Izbicki, {Jakob Robert} and Ronald Simon and Guido Sauter and Claudia Hube-Magg and Nathaniel Melling",
note = "{\textcopyright} 2021. The Author(s).",
year = "2021",
month = oct,
doi = "10.1007/s00432-021-03686-4",
language = "English",
volume = "147",
pages = "2879--2884",
journal = "J CANCER RES CLIN",
issn = "0171-5216",
publisher = "Springer",
number = "10",

}

RIS

TY - JOUR

T1 - Increased lysophosphatidylcholine acyltransferase 1 expression is unrelated to prognosis of esophageal cancer patients

AU - Bellon, Eugen

AU - Grupp, Katharina

AU - Ghadban, Tarik

AU - Tachezy, Michael

AU - Bachmann, Kai

AU - Izbicki, Jakob Robert

AU - Simon, Ronald

AU - Sauter, Guido

AU - Hube-Magg, Claudia

AU - Melling, Nathaniel

N1 - © 2021. The Author(s).

PY - 2021/10

Y1 - 2021/10

N2 - INTRODUCTION: Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has repeatedly been suggested to be associated with tumorigenesis. To evaluate the role of LPCAT1 in esophageal cancer, LPCAT1 immunostaining was analyzed on a tissue microarray containing samples from esophageal cancer patients.RESULTS: In benign esophageal tissue, LPCAT1 staining was detectable in low intensities. LPCAT1 staining was increased in malignant as compared to benign esophageal tissue and was found in high intensity in 26.4% of 288 interpretable esophageal adenocarcinomas (EACs) and in 23.2% of 211 squamous cell carcinomas (ESCCs). Increased LPCAT1 staining was linked to undifferentiated tumor grading in both subtypes of EACs and ESCCs (p = 0.0273 and p = 0.0085).CONCLUSION: However, LPCAT1 was not associated with prognosis of EAC and ESCC patients (p = 0.6838 and p = 0.4695) and thus cannot be considered a prognostic biomarker in esophageal cancers.

AB - INTRODUCTION: Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has repeatedly been suggested to be associated with tumorigenesis. To evaluate the role of LPCAT1 in esophageal cancer, LPCAT1 immunostaining was analyzed on a tissue microarray containing samples from esophageal cancer patients.RESULTS: In benign esophageal tissue, LPCAT1 staining was detectable in low intensities. LPCAT1 staining was increased in malignant as compared to benign esophageal tissue and was found in high intensity in 26.4% of 288 interpretable esophageal adenocarcinomas (EACs) and in 23.2% of 211 squamous cell carcinomas (ESCCs). Increased LPCAT1 staining was linked to undifferentiated tumor grading in both subtypes of EACs and ESCCs (p = 0.0273 and p = 0.0085).CONCLUSION: However, LPCAT1 was not associated with prognosis of EAC and ESCC patients (p = 0.6838 and p = 0.4695) and thus cannot be considered a prognostic biomarker in esophageal cancers.

U2 - 10.1007/s00432-021-03686-4

DO - 10.1007/s00432-021-03686-4

M3 - SCORING: Journal article

C2 - 34148155

VL - 147

SP - 2879

EP - 2884

JO - J CANCER RES CLIN

JF - J CANCER RES CLIN

SN - 0171-5216

IS - 10

ER -